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Emerg Infect Dis
; 30(5): 1004-1008, 2024 May.
Article
in English
| MEDLINE
| ID: mdl-38666640
ABSTRACT
We evaluated the in vitro effects of lyophilization for 2 vesicular stomatitis virus-based vaccines by using 3 stabilizing formulations and demonstrated protective immunity of lyophilized/reconstituted vaccine in guinea pigs. Lyophilization increased stability of the vaccines, but specific vesicular stomatitis virus-based vaccines will each require extensive analysis to optimize stabilizing formulations.