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1.
Uncialamycin-based antibody-drug conjugates: Unique enediyne ADCs exhibiting bystander killing effect.
Proc Natl Acad Sci U S A
; 118(25)2021 06 22.
Article
in English
| MEDLINE | ID: mdl-34155147
2.
Design, Synthesis, and Biological Investigation of Thailanstatin A and Spliceostatin D Analogues Containing Tetrahydropyran, Tetrahydrooxazine, and Fluorinated Structural Motifs.
J Org Chem
; 86(3): 2499-2521, 2021 02 05.
Article
in English
| MEDLINE | ID: mdl-33417458
3.
Design, Synthesis, and Biological Evaluation of Tubulysin Analogues, Linker-Drugs, and Antibody-Drug Conjugates, Insights into Structure-Activity Relationships, and Tubulysin-Tubulin Binding Derived from X-ray Crystallographic Analysis.
J Org Chem
; 86(4): 3377-3421, 2021 02 19.
Article
in English
| MEDLINE | ID: mdl-33544599
4.
Total Synthesis and Biological Evaluation of Tiancimycins A and B, Yangpumicin A, and Related Anthraquinone-Fused Enediyne Antitumor Antibiotics.
J Am Chem Soc
; 142(5): 2549-2561, 2020 02 05.
Article
in English
| MEDLINE | ID: mdl-31976660
5.
Streamlined Symmetrical Total Synthesis of Disorazole B1 and Design, Synthesis, and Biological Investigation of Disorazole Analogues.
J Am Chem Soc
; 142(36): 15476-15487, 2020 09 09.
Article
in English
| MEDLINE | ID: mdl-32852944
6.
Synthesis and Biological Evaluation of Shishijimicin A-Type Linker-Drugs and Antibody-Drug Conjugates.
J Am Chem Soc
; 142(29): 12890-12899, 2020 07 22.
Article
in English
| MEDLINE | ID: mdl-32662641
7.
Design, Synthesis, and Biological Investigation of Epothilone B Analogues Featuring Lactone, Lactam, and Carbocyclic Macrocycles, Epoxide, Aziridine, and 1,1-Difluorocyclopropane and Other Fluorine Residues.
J Org Chem
; 85(5): 2865-2917, 2020 03 06.
Article
in English
| MEDLINE | ID: mdl-32065746
8.
Evaluation of PNU-159682 antibody drug conjugates (ADCs).
Bioorg Med Chem Lett
; 30(24): 127640, 2020 12 15.
Article
in English
| MEDLINE | ID: mdl-33127540
9.
Short Total Synthesis of Δ12-Prostaglandin J2 and Related Prostaglandins. Design, Synthesis, and Biological Evaluation of Macrocyclic Δ12-Prostaglandin J2 Analogues.
J Org Chem
; 84(1): 365-378, 2019 01 04.
Article
in English
| MEDLINE | ID: mdl-30557504
10.
Improved Total Synthesis of Tubulysins and Design, Synthesis, and Biological Evaluation of New Tubulysins with Highly Potent Cytotoxicities against Cancer Cells as Potential Payloads for Antibody-Drug Conjugates.
J Am Chem Soc
; 140(10): 3690-3711, 2018 03 14.
Article
in English
| MEDLINE | ID: mdl-29381062
11.
Streamlined Total Synthesis of Shishijimicin A and Its Application to the Design, Synthesis, and Biological Evaluation of Analogues thereof and Practical Syntheses of PhthNSSMe and Related Sulfenylating Reagents.
J Am Chem Soc
; 140(38): 12120-12136, 2018 09 26.
Article
in English
| MEDLINE | ID: mdl-30216054
12.
12,13-Aziridinyl Epothilones. Stereoselective Synthesis of Trisubstituted Olefinic Bonds from Methyl Ketones and Heteroaromatic Phosphonates and Design, Synthesis, and Biological Evaluation of Potent Antitumor Agents.
J Am Chem Soc
; 139(21): 7318-7334, 2017 05 31.
Article
in English
| MEDLINE | ID: mdl-28513142
13.
Streamlined Total Synthesis of Trioxacarcins and Its Application to the Design, Synthesis, and Biological Evaluation of Analogues Thereof. Discovery of Simpler Designed and Potent Trioxacarcin Analogues.
J Am Chem Soc
; 139(43): 15467-15478, 2017 11 01.
Article
in English
| MEDLINE | ID: mdl-29052423
14.
Total Synthesis and Biological Evaluation of Natural and Designed Tubulysins.
J Am Chem Soc
; 138(5): 1698-708, 2016 Feb 10.
Article
in English
| MEDLINE | ID: mdl-26829208
15.
Synthesis and Biological Investigation of Δ(12)-Prostaglandin J3 (Δ(12)-PGJ3) Analogues and Related Compounds.
J Am Chem Soc
; 138(20): 6550-60, 2016 05 25.
Article
in English
| MEDLINE | ID: mdl-27171618
16.
Correction to "Short Total Synthesis of Δ12-Prostaglandin J2 and Related Prostaglandins. Design, Synthesis, and Biological Evaluation of Macrocyclic Δ12-Prostaglandin J2 Analogues".
J Org Chem
; 84(4): 2377-2378, 2019 Feb 15.
Article
in English
| MEDLINE | ID: mdl-30715889
17.
Noninvasive Interrogation of DLL3 Expression in Metastatic Small Cell Lung Cancer.
Cancer Res
; 77(14): 3931-3941, 2017 07 15.
Article
in English
| MEDLINE | ID: mdl-28487384
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