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Nature ; 597(7877): 539-543, 2021 09.
Article in English | MEDLINE | ID: mdl-34526718

ABSTRACT

Seven years after the declaration of the first epidemic of Ebola virus disease in Guinea, the country faced a new outbreak-between 14 February and 19 June 2021-near the epicentre of the previous epidemic1,2. Here we use next-generation sequencing to generate complete or near-complete genomes of Zaire ebolavirus from samples obtained from 12 different patients. These genomes form a well-supported phylogenetic cluster with genomes from the previous outbreak, which indicates that the new outbreak was not the result of a new spillover event from an animal reservoir. The 2021 lineage shows considerably lower divergence than would be expected during sustained human-to-human transmission, which suggests a persistent infection with reduced replication or a period of latency. The resurgence of Zaire ebolavirus from humans five years after the end of the previous outbreak of Ebola virus disease reinforces the need for long-term medical and social care for patients who survive the disease, to reduce the risk of re-emergence and to prevent further stigmatization.


Subject(s)
Disease Outbreaks , Ebolavirus/genetics , Ebolavirus/isolation & purification , Hemorrhagic Fever, Ebola/epidemiology , Hemorrhagic Fever, Ebola/virology , Models, Biological , Animals , Democratic Republic of the Congo/epidemiology , Disease Outbreaks/statistics & numerical data , Ebolavirus/classification , Female , Guinea/epidemiology , Hemorrhagic Fever, Ebola/transmission , High-Throughput Nucleotide Sequencing , Humans , Male , Persistent Infection/virology , Phylogeny , Survivors , Time Factors , Viral Zoonoses/transmission , Viral Zoonoses/virology
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