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1.
Human Intravenous Immunoglobulin Alleviates Neuropathic Symptoms in a Rat Model of Paclitaxel-Induced Peripheral Neurotoxicity.
Int J Mol Sci
; 22(3)2021 Jan 21.
Article
in English
| MEDLINE | ID: mdl-33494384
2.
High-dose intravenous immunoglobulins reduce nerve macrophage infiltration and the severity of bortezomib-induced peripheral neurotoxicity in rats.
J Neuroinflammation
; 15(1): 232, 2018 Aug 21.
Article
in English
| MEDLINE | ID: mdl-30131066
3.
siRNA screen identifies QPCT as a druggable target for Huntington's disease.
Nat Chem Biol
; 11(5): 347-354, 2015 May.
Article
in English
| MEDLINE | ID: mdl-25848931
4.
Recombinant Adeno Associated Viral (AAV) vector type 9 delivery of Ex1-Q138-mutant huntingtin in the rat striatum as a short-time model for in vivo studies in drug discovery.
Neurobiol Dis
; 86: 41-51, 2016 Feb.
Article
in English
| MEDLINE | ID: mdl-26626080
5.
A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease.
Hum Mol Genet
; 23(11): 2995-3007, 2014 Jun 01.
Article
in English
| MEDLINE | ID: mdl-24436303
6.
New orphan disease therapies from the proteome of industrial plasma processing waste- a treatment for aceruloplasminemia.
Commun Biol
; 7(1): 140, 2024 01 30.
Article
in English
| MEDLINE | ID: mdl-38291108
7.
VSTM2L is a novel secreted antagonist of the neuroprotective peptide Humanin.
FASEB J
; 25(6): 1983-2000, 2011 Jun.
Article
in English
| MEDLINE | ID: mdl-21393573
8.
Increased Dickkopf-1 expression in transgenic mouse models of neurodegenerative disease.
J Neurochem
; 112(6): 1539-51, 2010 Mar.
Article
in English
| MEDLINE | ID: mdl-20050968
9.
Procognitive and neuroprotective activity of a novel alpha7 nicotinic acetylcholine receptor agonist for treatment of neurodegenerative and cognitive disorders.
J Pharmacol Exp Ther
; 329(2): 459-68, 2009 May.
Article
in English
| MEDLINE | ID: mdl-19223665
10.
SAR and biological evaluation of SEN12333/WAY-317538: Novel alpha 7 nicotinic acetylcholine receptor agonist.
Bioorg Med Chem
; 17(14): 5247-58, 2009 Jul 15.
Article
in English
| MEDLINE | ID: mdl-19515567
11.
Multimodal molecular imaging system for pathway-specific reporter gene expression.
Eur J Pharm Sci
; 86: 136-42, 2016 Apr 30.
Article
in English
| MEDLINE | ID: mdl-26987608
12.
Neutrophils CD11b and fibroblasts PGE(2) are elevated in Alzheimer's disease.
Neurobiol Aging
; 23(4): 523-30, 2002.
Article
in English
| MEDLINE | ID: mdl-12009501
13.
Fused 3-Hydroxy-3-trifluoromethylpyrazoles Inhibit Mutant Huntingtin Toxicity.
ACS Med Chem Lett
; 4(10): 979-84, 2013 Oct 10.
Article
in English
| MEDLINE | ID: mdl-24900595
14.
N-[5-(5-fluoropyridin-3-yl)-1H-pyrazol-3-yl]-4-piperidin-1-ylbutyramide (SEN78702, WYE-308775): a medicinal chemistry effort toward an α7 nicotinic acetylcholine receptor agonist preclinical candidate.
J Med Chem
; 55(22): 10277-81, 2012 Nov 26.
Article
in English
| MEDLINE | ID: mdl-23083093
15.
Discovery of a novel alpha-7 nicotinic acetylcholine receptor agonist series and characterization of the potent, selective, and orally efficacious agonist 5-(4-acetyl[1,4]diazepan-1-yl)pentanoic acid [5-(4-methoxyphenyl)-1H-pyrazol-3-yl] amide (SEN15924, WAY-361789).
J Med Chem
; 55(10): 4806-23, 2012 May 24.
Article
in English
| MEDLINE | ID: mdl-22468936
16.
Preclinical assessment of an adjunctive treatment approach for cognitive impairment associated with schizophrenia using the alpha7 nicotinic acetylcholine receptor agonist WYE-103914/SEN34625.
Psychopharmacology (Berl)
; 218(4): 635-47, 2011 Dec.
Article
in English
| MEDLINE | ID: mdl-21643676
17.
Novel alpha-7 nicotinic acetylcholine receptor agonists containing a urea moiety: identification and characterization of the potent, selective, and orally efficacious agonist 1-[6-(4-fluorophenyl)pyridin-3-yl]-3-(4-piperidin-1-ylbutyl) urea (SEN34625/WYE-103914).
J Med Chem
; 53(11): 4379-89, 2010 Jun 10.
Article
in English
| MEDLINE | ID: mdl-20465311
18.
Cholinergic dysfunction, neuronal damage and axonal loss in TgCRND8 mice.
Neurobiol Dis
; 23(2): 260-72, 2006 Aug.
Article
in English
| MEDLINE | ID: mdl-16766197
19.
Inhibition of Wnt signaling, modulation of Tau phosphorylation and induction of neuronal cell death by DKK1.
Neurobiol Dis
; 24(2): 254-65, 2006 Nov.
Article
in English
| MEDLINE | ID: mdl-16919965
20.
Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent.
Proc Natl Acad Sci U S A
; 102(47): 17213-8, 2005 Nov 22.
Article
in English
| MEDLINE | ID: mdl-16275899