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1.
Recommendations on the Use of Multiple Labels in Human Mass Balance Studies.
Drug Metab Dispos
; 52(3): 153-158, 2024 Feb 14.
Article
in English
| MEDLINE | ID: mdl-38216306
2.
Discovery and characterisation of quinazolines and 8-Azaquinazolines as NLRP3 agonists with oral bioavailability in mice.
Bioorg Med Chem Lett
; 96: 129518, 2023 11 15.
Article
in English
| MEDLINE | ID: mdl-37838344
3.
Clinical evaluation of the potential drug-drug interactions of savolitinib: Interaction with rifampicin, itraconazole, famotidine or midazolam.
Br J Clin Pharmacol
; 88(2): 655-668, 2022 02.
Article
in English
| MEDLINE | ID: mdl-34322894
4.
Improving metabolic stability and removing aldehyde oxidase liability in a 5-azaquinazoline series of IRAK4 inhibitors.
Bioorg Med Chem
; 28(23): 115815, 2020 12 01.
Article
in English
| MEDLINE | ID: mdl-33091850
5.
In vitro evaluation of the inhibition and induction potential of olaparib, a potent poly(ADP-ribose) polymerase inhibitor, on cytochrome P450.
Xenobiotica
; 48(6): 555-564, 2018 Jun.
Article
in English
| MEDLINE | ID: mdl-28657402
6.
CYP-Mediated Sulfoximine Deimination of AZD6738.
Drug Metab Dispos
; 45(11): 1133-1138, 2017 11.
Article
in English
| MEDLINE | ID: mdl-28835442
7.
Non-Labeled, Stable Labeled, or Radiolabelled Approaches for Provision of Intravenous Pharmacokinetics in Humans: A Discussion Piece.
Clin Pharmacol Ther
; 115(5): 931-938, 2024 May.
Article
in English
| MEDLINE | ID: mdl-38018358
8.
A Phase 1 Study to Evaluate Absolute Bioavailability and Absorption, Distribution, Metabolism, and Excretion of Savolitinib in Healthy Male Volunteers.
Clin Pharmacol Drug Dev
; 12(4): 424-435, 2023 04.
Article
in English
| MEDLINE | ID: mdl-36808891
9.
A PKPD Case Study: Achieving Clinically Relevant Exposures of AZD5991 in Oncology Mouse Models.
AAPS J
; 25(4): 66, 2023 06 28.
Article
in English
| MEDLINE | ID: mdl-37380821
10.
Considerations for Human ADME Strategy and Design Paradigm Shift(s) - An Industry White Paper.
Clin Pharmacol Ther
; 113(4): 775-781, 2023 04.
Article
in English
| MEDLINE | ID: mdl-35733280
11.
Physiologically Based Pharmacokinetic Modeling for Olaparib Dosing Recommendations: Bridging Formulations, Drug Interactions, and Patient Populations.
Clin Pharmacol Ther
; 105(1): 229-241, 2019 01.
Article
in English
| MEDLINE | ID: mdl-29717476
12.
Phase I study of orally administered 14Carbon-isotope labelled-vistusertib (AZD2014), a dual TORC1/2 kinase inhibitor, to assess the absorption, metabolism, excretion, and pharmacokinetics in patients with advanced solid malignancies.
Cancer Chemother Pharmacol
; 83(4): 787-795, 2019 04.
Article
in English
| MEDLINE | ID: mdl-30758651
13.
Pharmacokinetics, absorption, and excretion of radiolabeled revexepride: a Phase I clinical trial using a microtracer and accelerator mass spectrometry-based approach.
Drug Des Devel Ther
; 10: 3125-3132, 2016.
Article
in English
| MEDLINE | ID: mdl-27729771
14.
A Phase I Study to Investigate the Absorption, Pharmacokinetics, and Excretion of [(14)C]Prucalopride After a Single Oral Dose in Healthy Volunteers.
Clin Ther
; 38(9): 2106-15, 2016 Sep.
Article
in English
| MEDLINE | ID: mdl-27614912
15.
Virtual chromatographic resolution enhancement in cryoflow LC-NMR experiments via statistical total correlation spectroscopy.
Anal Chem
; 79(9): 3304-11, 2007 May 01.
Article
in English
| MEDLINE | ID: mdl-17394288
16.
The olivacine derivative s 16020 (9-hydroxy-5,6-dimethyl-N-[2-(dimethylamino)ethyl)-6H-pyrido(4,3-B)-carbazole-1-carboxamide) induces CYP1A and its own metabolism in human hepatocytes in primary culture.
Drug Metab Dispos
; 32(1): 80-8, 2004 Jan.
Article
in English
| MEDLINE | ID: mdl-14709624
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