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1.
ABCC4 impacts megakaryopoiesis and protects megakaryocytes against 6-mercaptopurine induced cytotoxicity.
Drug Resist Updat
; 72: 101017, 2024 Jan.
Article
in English
| MEDLINE | ID: mdl-37988981
2.
Genetic effects on liver chromatin accessibility identify disease regulatory variants.
Am J Hum Genet
; 108(7): 1169-1189, 2021 07 01.
Article
in English
| MEDLINE | ID: mdl-34038741
3.
Zebrafish abcb11b mutant reveals strategies to restore bile excretion impaired by bile salt export pump deficiency.
Hepatology
; 67(4): 1531-1545, 2018 04.
Article
in English
| MEDLINE | ID: mdl-29091294
4.
Novel CYP2A6 diplotypes identified through next-generation sequencing are associated with in-vitro and in-vivo nicotine metabolism.
Pharmacogenet Genomics
; 28(1): 7-16, 2018 Jan.
Article
in English
| MEDLINE | ID: mdl-29232328
5.
Pheophorbide A: Fluorescent Bcrp Substrate to Measure Oral Drug-Drug Interactions in Real-Time In Vivo.
Drug Metab Dispos
; 46(11): 1725-1733, 2018 11.
Article
in English
| MEDLINE | ID: mdl-30111622
6.
Ketamine Pharmacokinetics and Pharmacodynamics Are Altered by P-Glycoprotein and Breast Cancer Resistance Protein Efflux Transporters in Mice.
Drug Metab Dispos
; 46(7): 1014-1022, 2018 07.
Article
in English
| MEDLINE | ID: mdl-29674491
7.
Beyond Competitive Inhibition: Regulation of ABC Transporters by Kinases and Protein-Protein Interactions as Potential Mechanisms of Drug-Drug Interactions.
Drug Metab Dispos
; 46(5): 567-580, 2018 05.
Article
in English
| MEDLINE | ID: mdl-29514827
8.
Polymorphic Human Sulfotransferase 2A1 Mediates the Formation of 25-Hydroxyvitamin D3-3-O-Sulfate, a Major Circulating Vitamin D Metabolite in Humans.
Drug Metab Dispos
; 46(4): 367-379, 2018 04.
Article
in English
| MEDLINE | ID: mdl-29343609
9.
Hepatic Abundance and Activity of Androgen- and Drug-Metabolizing Enzyme UGT2B17 Are Associated with Genotype, Age, and Sex.
Drug Metab Dispos
; 46(6): 888-896, 2018 06.
Article
in English
| MEDLINE | ID: mdl-29602798
10.
Predictors of Variation in CYP2A6 mRNA, Protein, and Enzyme Activity in a Human Liver Bank: Influence of Genetic and Nongenetic Factors.
J Pharmacol Exp Ther
; 360(1): 129-139, 2017 Jan.
Article
in English
| MEDLINE | ID: mdl-27815364
11.
CRISPR/Cas9 Genetic Modification of CYP3A5 *3 in HuH-7 Human Hepatocyte Cell Line Leads to Cell Lines with Increased Midazolam and Tacrolimus Metabolism.
Drug Metab Dispos
; 45(8): 957-965, 2017 08.
Article
in English
| MEDLINE | ID: mdl-28533324
12.
Expression Patterns of Organic Anion Transporting Polypeptides 1B1 and 1B3 Protein in Human Pediatric Liver.
Drug Metab Dispos
; 44(7): 999-1004, 2016 07.
Article
in English
| MEDLINE | ID: mdl-27098745
13.
Interindividual Variability in Cytochrome P450-Mediated Drug Metabolism.
Drug Metab Dispos
; 44(3): 343-51, 2016 Mar.
Article
in English
| MEDLINE | ID: mdl-26681736
14.
In Vivo Imaging of Human MDR1 Transcription in the Brain and Spine of MDR1-Luciferase Reporter Mice.
Drug Metab Dispos
; 43(11): 1646-54, 2015 Nov.
Article
in English
| MEDLINE | ID: mdl-26281846
15.
The CYP2C19 Intron 2 Branch Point SNP is the Ancestral Polymorphism Contributing to the Poor Metabolizer Phenotype in Livers with CYP2C19*35 and CYP2C19*2 Alleles.
Drug Metab Dispos
; 43(8): 1226-35, 2015 Aug.
Article
in English
| MEDLINE | ID: mdl-26021325
16.
Why do most human liver cytosol preparations lack xanthine oxidase activity?
Drug Metab Dispos
; 42(4): 695-9, 2014 Apr.
Article
in English
| MEDLINE | ID: mdl-24430612
17.
Multisite phosphorylation of human liver cytochrome P450 3A4 enhances Its gp78- and CHIP-mediated ubiquitination: a pivotal role of its Ser-478 residue in the gp78-catalyzed reaction.
Mol Cell Proteomics
; 11(2): M111.010132, 2012 Feb.
Article
in English
| MEDLINE | ID: mdl-22101235
18.
Genetic variation in aldo-keto reductase 1D1 (AKR1D1) affects the expression and activity of multiple cytochrome P450s.
Drug Metab Dispos
; 41(8): 1538-47, 2013 Aug.
Article
in English
| MEDLINE | ID: mdl-23704699
19.
Drug transporters on arachnoid barrier cells contribute to the blood-cerebrospinal fluid barrier.
Drug Metab Dispos
; 41(4): 923-31, 2013 Apr.
Article
in English
| MEDLINE | ID: mdl-23298861
20.
The influence of sex, ethnicity, and CYP2B6 genotype on bupropion metabolism as an index of hepatic CYP2B6 activity in humans.
Drug Metab Dispos
; 41(3): 575-81, 2013 Mar.
Article
in English
| MEDLINE | ID: mdl-23238783