Search details
1.
SMN protein is required throughout life to prevent spinal muscular atrophy disease progression.
Hum Mol Genet
; 31(1): 82-96, 2021 12 17.
Article
in English
| MEDLINE | ID: mdl-34368854
2.
Efficacy of the novel tubulin polymerization inhibitor PTC-028 for myelodysplastic syndrome.
Cancer Sci
; 111(12): 4336-4347, 2020 Dec.
Article
in English
| MEDLINE | ID: mdl-33037737
3.
The nucleoside analog clitocine is a potent and efficacious readthrough agent.
RNA
; 23(4): 567-577, 2017 04.
Article
in English
| MEDLINE | ID: mdl-28096517
4.
Pharmacokinetics, pharmacodynamics, and efficacy of a small-molecule SMN2 splicing modifier in mouse models of spinal muscular atrophy.
Hum Mol Genet
; 25(10): 1885-1899, 2016 05 15.
Article
in English
| MEDLINE | ID: mdl-26931466
5.
4-Hydroxy-2-pyridones: Discovery and evaluation of a novel class of antibacterial agents targeting DNA synthesis.
Bioorg Med Chem Lett
; 27(22): 5014-5021, 2017 11 15.
Article
in English
| MEDLINE | ID: mdl-29032026
6.
SAR studies toward discovery of emvododstat (PTC299), a potent dihydroorotate dehydrogenase (DHODH) inhibitor.
Eur J Med Chem
; 244: 114826, 2022 Dec 15.
Article
in English
| MEDLINE | ID: mdl-36242990
7.
Emvododstat, a Potent Dihydroorotate Dehydrogenase Inhibitor, Is Effective in Preclinical Models of Acute Myeloid Leukemia.
Front Oncol
; 12: 832816, 2022.
Article
in English
| MEDLINE | ID: mdl-35223511
8.
BMI1 as a novel target for drug discovery in cancer.
J Cell Biochem
; 112(10): 2729-41, 2011 Oct.
Article
in English
| MEDLINE | ID: mdl-21678481
9.
DHODH inhibition synergizes with DNA-demethylating agents in the treatment of myelodysplastic syndromes.
Blood Adv
; 5(2): 438-450, 2021 01 26.
Article
in English
| MEDLINE | ID: mdl-33496740
10.
The combination of the tubulin binding small molecule PTC596 and proteasome inhibitors suppresses the growth of myeloma cells.
Sci Rep
; 11(1): 2074, 2021 01 22.
Article
in English
| MEDLINE | ID: mdl-33483574
11.
Preclinical and Early Clinical Development of PTC596, a Novel Small-Molecule Tubulin-Binding Agent.
Mol Cancer Ther
; 20(10): 1846-1857, 2021 10.
Article
in English
| MEDLINE | ID: mdl-34315764
12.
Chemical modifications of G418 (geneticin): Synthesis of novel readthrough aminoglycosides results in an improved in vitro safety window but no improvements in vivo.
Carbohydr Res
; 495: 108058, 2020 Sep.
Article
in English
| MEDLINE | ID: mdl-32658832
13.
Effective Delivery of a Microtubule Polymerization Inhibitor Synergizes with Standard Regimens in Models of Pancreatic Ductal Adenocarcinoma.
Clin Cancer Res
; 25(18): 5548-5560, 2019 09 15.
Article
in English
| MEDLINE | ID: mdl-31175095
14.
Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties.
Mol Cancer Ther
; 18(1): 3-16, 2019 01.
Article
in English
| MEDLINE | ID: mdl-30352802
15.
BMI1 is a therapeutic target in recurrent medulloblastoma.
Oncogene
; 38(10): 1702-1716, 2019 03.
Article
in English
| MEDLINE | ID: mdl-30348991
16.
The minor gentamicin complex component, X2, is a potent premature stop codon readthrough molecule with therapeutic potential.
PLoS One
; 13(10): e0206158, 2018.
Article
in English
| MEDLINE | ID: mdl-30359426
17.
Discovery and Optimization of Indolyl-Containing 4-Hydroxy-2-Pyridone Type II DNA Topoisomerase Inhibitors Active against Multidrug Resistant Gram-negative Bacteria.
J Med Chem
; 61(10): 4456-4475, 2018 05 24.
Article
in English
| MEDLINE | ID: mdl-29727185
18.
Discovery of Novel Small Molecule Inhibitors of VEGF Expression in Tumor Cells Using a Cell-Based High Throughput Screening Platform.
PLoS One
; 11(12): e0168366, 2016.
Article
in English
| MEDLINE | ID: mdl-27992500
19.
Discovery and Optimization of Small Molecule Splicing Modifiers of Survival Motor Neuron 2 as a Treatment for Spinal Muscular Atrophy.
J Med Chem
; 59(13): 6070-85, 2016 07 14.
Article
in English
| MEDLINE | ID: mdl-27299569
20.
Radiotherapy of human xenograft NSCLC tumors in nude mice with a 90Y-labeled anti-tissue factor antibody.
Cancer Biother Radiopharm
; 20(3): 300-9, 2005 Jun.
Article
in English
| MEDLINE | ID: mdl-15989475