ABSTRACT
Herpes simplex virus type 2 (HHV-2) is one of the most common sexually transmitted diseases in the world. In the immunocompromised host, including patients with human immunodeficiency virus (HIV), herpes simplex virus is at high risk for reactivation. We present a woman with HIV and a large ulcer of the palm determined to be HHV-2. Not only was the location of her ulcer unusual, but her CD4 lymphocyte count continued to drop despite improvement of the palmar ulceration with treatment. As a result, her palmar HHV-2 ulcer became an AIDS-defining complex.
Subject(s)
Acquired Immunodeficiency Syndrome/complications , Herpes Simplex/diagnosis , Herpesvirus 2, Human/isolation & purification , AIDS-Related Opportunistic Infections/diagnosis , AIDS-Related Opportunistic Infections/virology , Acquired Immunodeficiency Syndrome/diagnosis , Adult , CD4 Lymphocyte Count , Female , Hand , Herpes Simplex/virology , HumansABSTRACT
Acute hemorrhagic edema of infancy (AHEI) is an unusual form of leukocytoclastic vasculitis that affects children younger than 2 years and frequently is preceded by drug intake, vaccination, or a variety of infections. It is characterized by an abrupt onset of fever, purpuric lesions, and peripheral edema on the face and extremities that may be confused with other dermatoses. The course is benign with spontaneous resolution. We present 2 infants with AHEI and review the clinical manifestations, histology, and differential diagnosis.