Subject(s)
COVID-19 Serological Testing/standards , Diagnostic Test Approval , Government Regulation , Marketing of Health Services/legislation & jurisprudence , United States Food and Drug Administration , Clinical Laboratory Techniques/standards , Diagnostic Test Approval/legislation & jurisprudence , Federal Government , Humans , Laboratories/legislation & jurisprudence , Laboratories/standards , Organizational Policy , United States , United States Food and Drug Administration/organization & administrationSubject(s)
Betacoronavirus , Clinical Laboratory Techniques , Coronavirus Infections/diagnosis , Molecular Diagnostic Techniques , Pneumonia, Viral/diagnosis , COVID-19 , COVID-19 Testing , Clinical Laboratory Techniques/methods , Clinical Laboratory Techniques/standards , Consumer Product Safety , False Positive Reactions , Humans , Pandemics , SARS-CoV-2 , Sensitivity and Specificity , United States , United States Food and Drug AdministrationABSTRACT
Investment, collaboration, and coordination have been key.
Subject(s)
Biomedical Research , COVID-19 , Humans , Biomedical Research/economics , Biomedical Research/trends , COVID-19/prevention & control , COVID-19/therapy , National Institutes of Health (U.S.) , Investments , International Cooperation , COVID-19 Vaccines , Clinical Trials as TopicSubject(s)
Biomedical Research/organization & administration , Equipment and Supplies , Technology Assessment, Biomedical/organization & administration , Data Collection/methods , Humans , Product Surveillance, Postmarketing/methods , United States , United States Food and Drug Administration/organization & administrationSubject(s)
Device Approval/standards , Equipment and Supplies/standards , Registries/statistics & numerical data , Consumer Product Safety/legislation & jurisprudence , Decision Making , Device Approval/legislation & jurisprudence , Equipment and Supplies/statistics & numerical data , Health Systems Agencies , Humans , Research Design/trendsABSTRACT
The frontal lobes are widely implicated in logical reasoning. Recent neuroimaging studies suggest that frontal lobe involvement in reasoning is asymmetric (L>R) and increases with the presence of familiar, meaningful content in the reasoning situation. However, neuroimaging data can only provide sufficiency criteria. To determine the necessity of prefrontal involvement in logical reasoning, we tested 19 patients with focal frontal lobe lesions and 19 age- and education-matched normal controls on the Wason Card Selection Task, while manipulating social knowledge. Patients and controls performed equivalently on the arbitrary rule condition. Normal controls showed the expected improvement in the social knowledge conditions, but frontal lobe patients failed to show this facilitation in performance. Furthermore, left hemisphere patients were more affected than right hemisphere patients, suggesting that frontal lobe involvement in reasoning is asymmetric (L>R) and necessary for reasoning about social situations.