1.
Intern Med J
; 53(12): 2162-2174, 2023 Dec.
Article
in English
| MEDLINE
| ID: mdl-37528613
ABSTRACT
Haematopoietic stem cell transplantation is a mainstay of therapy for numerous malignant and nonmalignant diseases. Endothelial activation and dysfunction occur after stem cell transplantation, driven by various patient- and transplant-specific factors. This can manifest as one of the relatively uncommon endothelial injury syndromes, such as sinusoidal obstruction syndrome, transplant-associated thrombotic microangiopathy, idiopathic pneumonia syndrome, capillary leak syndrome, engraftment syndrome or posterior reversible encephalopathy syndrome. This review focuses on the pathogenesis, classification and diagnosis of these disorders, as well as provides guidance on risk mitigation and treatment.
Subject(s)
Hematologic Diseases , Hematopoietic Stem Cell Transplantation , Pneumonia , Posterior Leukoencephalopathy Syndrome , Thrombotic Microangiopathies , Humans , Posterior Leukoencephalopathy Syndrome/complications , Hematopoietic Stem Cell Transplantation/adverse effects , Thrombotic Microangiopathies/diagnosis , Thrombotic Microangiopathies/etiology , Thrombotic Microangiopathies/therapy
2.
Intern Med J
; 48(10): 1277-1278, 2018 Oct.
Article
in English
| MEDLINE
| ID: mdl-30288906