Search details
1.
Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors.
Nature
; 504(7480): 437-40, 2013 Dec 19.
Article
in English
| MEDLINE | ID: mdl-24226772
2.
Pharmacological targeting of glucagon and glucagon-like peptide 1 receptors has different effects on energy state and glucose homeostasis in diet-induced obese mice.
J Pharmacol Exp Ther
; 338(1): 70-81, 2011 Jul.
Article
in English
| MEDLINE | ID: mdl-21471191
3.
Glucagon receptor antagonist-mediated improvements in glycemic control are dependent on functional pancreatic GLP-1 receptor.
Am J Physiol Endocrinol Metab
; 299(4): E624-32, 2010 Oct.
Article
in English
| MEDLINE | ID: mdl-20647556
4.
Chronic glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism desensitizes adipocyte GIPR activity mimicking functional GIPR antagonism.
Nat Commun
; 11(1): 4981, 2020 10 05.
Article
in English
| MEDLINE | ID: mdl-33020469
5.
Long-term inhibition of the glucagon receptor with a monoclonal antibody in mice causes sustained improvement in glycemic control, with reversible alpha-cell hyperplasia and hyperglucagonemia.
J Pharmacol Exp Ther
; 331(3): 871-81, 2009 Dec.
Article
in English
| MEDLINE | ID: mdl-19720878
6.
Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models.
Sci Transl Med
; 10(472)2018 12 19.
Article
in English
| MEDLINE | ID: mdl-30567927
7.
Pharmacologic Effects of FGF21 Are Independent of the "Browning" of White Adipose Tissue.
Cell Metab
; 21(5): 731-8, 2015 May 05.
Article
in English
| MEDLINE | ID: mdl-25955208
8.
Small Molecule Disruptors of the Glucokinase-Glucokinase Regulatory Protein Interaction: 5. A Novel Aryl Sulfone Series, Optimization Through Conformational Analysis.
J Med Chem
; 58(11): 4462-82, 2015 Jun 11.
Article
in English
| MEDLINE | ID: mdl-25914941
9.
Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase-Glucokinase Regulatory Protein (GK-GKRP) Binding: Strategic Use of a N â S (nN â σ*S-X) Interaction for Conformational Constraint.
J Med Chem
; 58(24): 9663-79, 2015 Dec 24.
Article
in English
| MEDLINE | ID: mdl-26551034
10.
Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 4. Exploration of a novel binding pocket.
J Med Chem
; 57(14): 5949-64, 2014 Jul 24.
Article
in English
| MEDLINE | ID: mdl-25001129
11.
Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 3. Structure-activity relationships within the aryl carbinol region of the N-arylsulfonamido-N'-arylpiperazine series.
J Med Chem
; 57(7): 3094-116, 2014 Apr 10.
Article
in English
| MEDLINE | ID: mdl-24611879
12.
Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 1. Discovery of a novel tool compound for in vivo proof-of-concept.
J Med Chem
; 57(2): 309-24, 2014 Jan 23.
Article
in English
| MEDLINE | ID: mdl-24405172
13.
Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 2. Leveraging structure-based drug design to identify analogues with improved pharmacokinetic profiles.
J Med Chem
; 57(2): 325-38, 2014 Jan 23.
Article
in English
| MEDLINE | ID: mdl-24405213
14.
Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice.
Diabetes
; 58(1): 250-9, 2009 Jan.
Article
in English
| MEDLINE | ID: mdl-18840786
Results
1 -
14
de 14
1
Next >
>>