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1.

Something old, something new: The marriage of PD-1 and IL-2.

Horton, Brendan L; Spranger, Stefani.

Immunity ; 56(1): 8-10, 2023 01 10.

Article in English | MEDLINE | ID: mdl-36630920

2.

Tissue-specific abundance of interferon-gamma drives regulatory T cells to restrain DC1-mediated priming of cytotoxic T cells against lung cancer.

Zagorulya, Maria; Yim, Leon; Morgan, Duncan M; Edwards, Austin; Torres-Mejia, Elen; Momin, Noor; McCreery, Chloe V; Zamora, Izabella L; Horton, Brendan L; Fox, James G; Wittrup, K Dane; Love, J Christopher; Spranger, Stefani.

Immunity ; 56(2): 386-405.e10, 2023 02 14.

Article in English | MEDLINE | ID: mdl-36736322

3.

Type I interferon activates MHC class I-dressed CD11b⁺ conventional dendritic cells to promote protective anti-tumor CD8⁺ T cell immunity.

Duong, Ellen; Fessenden, Tim B; Lutz, Emi; Dinter, Teresa; Yim, Leon; Blatt, Sarah; Bhutkar, Arjun; Wittrup, Karl Dane; Spranger, Stefani.

Immunity ; 55(2): 308-323.e9, 2022 02 08.

Article in English | MEDLINE | ID: mdl-34800368

4.

Increased demand for NAD⁺ relative to ATP drives aerobic glycolysis.

Luengo, Alba; Li, Zhaoqi; Gui, Dan Y; Sullivan, Lucas B; Zagorulya, Maria; Do, Brian T; Ferreira, Raphael; Naamati, Adi; Ali, Ahmed; Lewis, Caroline A; Thomas, Craig J; Spranger, Stefani; Matheson, Nicholas J; Vander Heiden, Matthew G.

Mol Cell ; 81(4): 691-707.e6, 2021 02 18.

Article in English | MEDLINE | ID: mdl-33382985

5.

Deciphering the immunopeptidome in vivo reveals new tumour antigens.

Jaeger, Alex M; Stopfer, Lauren E; Ahn, Ryuhjin; Sanders, Emma A; Sandel, Demi A; Freed-Pastor, William A; Rideout, William M; Naranjo, Santiago; Fessenden, Tim; Nguyen, Kim B; Winter, Peter S; Kohn, Ryan E; Westcott, Peter M K; Schenkel, Jason M; Shanahan, Sean-Luc; Shalek, Alex K; Spranger, Stefani; White, Forest M; Jacks, Tyler.

Nature ; 607(7917): 149-155, 2022 07.

Article in English | MEDLINE | ID: mdl-35705813

6.

CD36 - the Achilles' heel of T_reg cells.

Horton, Brendan L; Spranger, Stefani.

Nat Immunol ; 21(3): 251-253, 2020 03.

Article in English | MEDLINE | ID: mdl-32066948

7.

A Tumor Cell-Intrinsic Yin-Yang Determining Immune Evasion.

Horton, Brendan; Spranger, Stefani.

Immunity ; 49(1): 11-13, 2018 07 17.

Article in English | MEDLINE | ID: mdl-30021140

8.

MHC-dressing on dendritic cells: Boosting anti-tumor immunity via unconventional tumor antigen presentation.

Chatterjee, Fiona; Spranger, Stefani.

Semin Immunol ; 66: 101710, 2023 03.

Article in English | MEDLINE | ID: mdl-36640616

9.

Both intratumoral regulatory T cell depletion and CTLA-4 antagonism are required for maximum efficacy of anti-CTLA-4 antibodies.

Lax, Brianna M; Palmeri, Joseph R; Lutz, Emi A; Sheen, Allison; Stinson, Jordan A; Duhamel, Lauren; Santollani, Luciano; Kennedy, Alan; Rothschilds, Adrienne M; Spranger, Stefani; Sansom, David M; Wittrup, K Dane.

Proc Natl Acad Sci U S A ; 120(31): e2300895120, 2023 08.

Article in English | MEDLINE | ID: mdl-37487077

10.

Alum-anchored intratumoral retention improves the tolerability and antitumor efficacy of type I interferon therapies.

Lutz, Emi A; Agarwal, Yash; Momin, Noor; Cowles, Sarah C; Palmeri, Joseph R; Duong, Ellen; Hornet, Vladlena; Sheen, Allison; Lax, Brianna M; Rothschilds, Adrienne M; Irvine, Darrell J; Spranger, Stefani; Wittrup, K Dane.

Proc Natl Acad Sci U S A ; 119(36): e2205983119, 2022 09 06.

Article in English | MEDLINE | ID: mdl-36037341

11.

STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors.

Woo, Seng-Ryong; Fuertes, Mercedes B; Corrales, Leticia; Spranger, Stefani; Furdyna, Michael J; Leung, Michael Y K; Duggan, Ryan; Wang, Ying; Barber, Glen N; Fitzgerald, Katherine A; Alegre, Maria-Luisa; Gajewski, Thomas F.

Immunity ; 41(5): 830-42, 2014 Nov 20.

Article in English | MEDLINE | ID: mdl-25517615

12.

Melanoma-intrinsic ß-catenin signalling prevents anti-tumour immunity.

Spranger, Stefani; Bao, Riyue; Gajewski, Thomas F.

Nature ; 523(7559): 231-5, 2015 Jul 09.

Article in English | MEDLINE | ID: mdl-25970248

13.

Tumor Heterogeneity and Tumor Immunity: A Chicken-and-Egg Problem.

Spranger, Stefani.

Trends Immunol ; 37(6): 349-351, 2016 06.

Article in English | MEDLINE | ID: mdl-27166403

14.

Density of immunogenic antigens does not explain the presence or absence of the T-cell-inflamed tumor microenvironment in melanoma.

Spranger, Stefani; Luke, Jason J; Bao, Riyue; Zha, Yuanyuan; Hernandez, Kyle M; Li, Yan; Gajewski, Alexander P; Andrade, Jorge; Gajewski, Thomas F.

Proc Natl Acad Sci U S A ; 113(48): E7759-E7768, 2016 11 29.

Article in English | MEDLINE | ID: mdl-27837020

15.

Cutting Edge: Engineering Active IKKß in T Cells Drives Tumor Rejection.

Evaristo, César; Spranger, Stefani; Barnes, Sarah E; Miller, Michelle L; Molinero, Luciana L; Locke, Frederick L; Gajewski, Thomas F; Alegre, Maria-Luisa.

J Immunol ; 196(7): 2933-8, 2016 Apr 01.

Article in English | MEDLINE | ID: mdl-26903482

16.

Mechanisms of tumor escape in the context of the T-cell-inflamed and the non-T-cell-inflamed tumor microenvironment.

Spranger, Stefani.

Int Immunol ; 28(8): 383-91, 2016 08.

Article in English | MEDLINE | ID: mdl-26989092

17.

Cancer Immunotherapy Targets Based on Understanding the T Cell-Inflamed Versus Non-T Cell-Inflamed Tumor Microenvironment.

Gajewski, Thomas F; Corrales, Leticia; Williams, Jason; Horton, Brendan; Sivan, Ayelet; Spranger, Stefani.

Adv Exp Med Biol ; 1036: 19-31, 2017.

Article in English | MEDLINE | ID: mdl-29275462

18.

Future perspectives in melanoma research : Meeting report from the "Melanoma Bridge". Napoli, December 1st-4th 2015.

Ascierto, Paolo A; Agarwala, Sanjiv; Botti, Gerardo; Cesano, Alessandra; Ciliberto, Gennaro; Davies, Michael A; Demaria, Sandra; Dummer, Reinhard; Eggermont, Alexander M; Ferrone, Soldano; Fu, Yang Xin; Gajewski, Thomas F; Garbe, Claus; Huber, Veronica; Khleif, Samir; Krauthammer, Michael; Lo, Roger S; Masucci, Giuseppe; Palmieri, Giuseppe; Postow, Michael; Puzanov, Igor; Silk, Ann; Spranger, Stefani; Stroncek, David F; Tarhini, Ahmad; Taube, Janis M; Testori, Alessandro; Wang, Ena; Wargo, Jennifer A; Yee, Cassian; Zarour, Hassane; Zitvogel, Laurence; Fox, Bernard A; Mozzillo, Nicola; Marincola, Francesco M; Thurin, Magdalena.

J Transl Med ; 14(1): 313, 2016 11 15.

Article in English | MEDLINE | ID: mdl-27846884

19.

TCR-transgenic lymphocytes specific for HMMR/Rhamm limit tumor outgrowth in vivo.

Spranger, Stefani; Jeremias, Irmela; Wilde, Susanne; Leisegang, Matthias; Stärck, Lilian; Mosetter, Barbara; Uckert, Wolfgang; Heemskerk, Mirjam H M; Schendel, Dolores J; Frankenberger, Bernhard.

Blood ; 119(15): 3440-9, 2012 Apr 12.

Article in English | MEDLINE | ID: mdl-22371883

20.

A prime editor mouse to model a broad spectrum of somatic mutations in vivo.

Ely, Zackery A; Mathey-Andrews, Nicolas; Naranjo, Santiago; Gould, Samuel I; Mercer, Kim L; Newby, Gregory A; Cabana, Christina M; Rideout, William M; Jaramillo, Grissel Cervantes; Khirallah, Jennifer M; Holland, Katie; Randolph, Peyton B; Freed-Pastor, William A; Davis, Jessie R; Kulstad, Zachary; Westcott, Peter M K; Lin, Lin; Anzalone, Andrew V; Horton, Brendan L; Pattada, Nimisha B; Shanahan, Sean-Luc; Ye, Zhongfeng; Spranger, Stefani; Xu, Qiaobing; Sánchez-Rivera, Francisco J; Liu, David R; Jacks, Tyler.

Nat Biotechnol ; 42(3): 424-436, 2024 Mar.

Article in English | MEDLINE | ID: mdl-37169967

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