Search details
1.
Design, synthesis, and evaluation of BCL-2 targeting PROTACs.
Chemistry
; : e202400430, 2024 May 31.
Article
in English
| MEDLINE | ID: mdl-38818652
2.
E3 ligase ligand chemistries: from building blocks to protein degraders.
Chem Soc Rev
; 51(9): 3487-3534, 2022 May 10.
Article
in English
| MEDLINE | ID: mdl-35393989
3.
Design, synthesis, and characterization of PROTACs targeting the androgen receptor in prostate and lung cancer models.
Arch Pharm (Weinheim)
; 355(5): e2100467, 2022 May.
Article
in English
| MEDLINE | ID: mdl-35128717
4.
On the correlation of cereblon binding, fluorination and antiangiogenic properties of immunomodulatory drugs.
Biochem Biophys Res Commun
; 534: 67-72, 2021 01 01.
Article
in English
| MEDLINE | ID: mdl-33310190
5.
Another structural correction for 1-oxo-1H-phenalene-2,3-dicarbonitriles: Synthesis of a potent BCL-2 inhibiting 7-phenoxy derivative.
Arch Pharm (Weinheim)
; 354(10): e2100151, 2021 Oct.
Article
in English
| MEDLINE | ID: mdl-34173255
6.
Lenalidomide and pomalidomide potently interfere with induction of myeloid-derived suppressor cells in multiple myeloma.
Br J Haematol
; 191(5): 784-795, 2020 12.
Article
in English
| MEDLINE | ID: mdl-32558939
7.
Antiangiogenic Activity and in Silico Cereblon Binding Analysis of Novel Thalidomide Analogs.
Molecules
; 25(23)2020 Dec 02.
Article
in English
| MEDLINE | ID: mdl-33276504
8.
Development of an active-site titrant for SARS-CoV-2 main protease as an indispensable tool for evaluating enzyme kinetics.
Acta Pharm Sin B
; 14(5): 2349-2357, 2024 May.
Article
in English
| MEDLINE | ID: mdl-38799620
9.
Solubility Enhanced Formulation Approaches to Overcome Oral Delivery Obstacles of PROTACs.
Pharmaceutics
; 15(1)2023 Jan 03.
Article
in English
| MEDLINE | ID: mdl-36678785
10.
Heterobifunctional Ligase Recruiters Enable pan-Degradation of Inhibitor of Apoptosis Proteins.
J Med Chem
; 66(7): 4703-4733, 2023 04 13.
Article
in English
| MEDLINE | ID: mdl-36996313
11.
Expanding the Structural Diversity at the Phenylene Core of Ligands for the von Hippel-Lindau E3 Ubiquitin Ligase: Development of Highly Potent Hypoxia-Inducible Factor-1α Stabilizers.
J Med Chem
; 66(18): 12776-12811, 2023 09 28.
Article
in English
| MEDLINE | ID: mdl-37708384
12.
Accessing three-branched high-affinity cereblon ligands for molecular glue and protein degrader design.
RSC Chem Biol
; 4(3): 229-234, 2023 Mar 08.
Article
in English
| MEDLINE | ID: mdl-36908700
13.
Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs.
J Med Chem
; 66(21): 14513-14543, 2023 11 09.
Article
in English
| MEDLINE | ID: mdl-37902300
14.
Encoding BRAF inhibitor functions in protein degraders.
RSC Med Chem
; 13(6): 731-736, 2022 Jun 22.
Article
in English
| MEDLINE | ID: mdl-35814929
15.
Targeting the deubiquitinase USP7 for degradation with PROTACs.
Chem Commun (Camb)
; 58(63): 8858-8861, 2022 Aug 04.
Article
in English
| MEDLINE | ID: mdl-35852517
16.
Development of the first non-hydroxamate selective HDAC6 degraders.
Chem Commun (Camb)
; 58(79): 11087-11090, 2022 Oct 04.
Article
in English
| MEDLINE | ID: mdl-36098075
17.
Andrographolide Derivatives Target the KEAP1/NRF2 Axis and Possess Potent Anti-SARS-CoV-2 Activity.
ChemMedChem
; 17(5): e202100732, 2022 03 04.
Article
in English
| MEDLINE | ID: mdl-35099120
18.
Proteomic profiling reveals CDK6 upregulation as a targetable resistance mechanism for lenalidomide in multiple myeloma.
Nat Commun
; 13(1): 1009, 2022 02 23.
Article
in English
| MEDLINE | ID: mdl-35197447
19.
E3 Ligase Ligands in Successful PROTACs: An Overview of Syntheses and Linker Attachment Points.
Front Chem
; 9: 707317, 2021.
Article
in English
| MEDLINE | ID: mdl-34291038
20.
Influence of Linker Attachment Points on the Stability and Neosubstrate Degradation of Cereblon Ligands.
ACS Med Chem Lett
; 12(11): 1733-1738, 2021 Nov 11.
Article
in English
| MEDLINE | ID: mdl-34795861