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1.

Pan-cancer analyses reveal cancer-type-specific fungal ecologies and bacteriome interactions.

Narunsky-Haziza, Lian; Sepich-Poore, Gregory D; Livyatan, Ilana; Asraf, Omer; Martino, Cameron; Nejman, Deborah; Gavert, Nancy; Stajich, Jason E; Amit, Guy; González, Antonio; Wandro, Stephen; Perry, Gili; Ariel, Ruthie; Meltser, Arnon; Shaffer, Justin P; Zhu, Qiyun; Balint-Lahat, Nora; Barshack, Iris; Dadiani, Maya; Gal-Yam, Einav N; Patel, Sandip Pravin; Bashan, Amir; Swafford, Austin D; Pilpel, Yitzhak; Knight, Rob; Straussman, Ravid.

Cell ; 185(20): 3789-3806.e17, 2022 09 29.

Article in English | MEDLINE | ID: mdl-36179670

2.

Microbial exposure during early human development primes fetal immune cells.

Mishra, Archita; Lai, Ghee Chuan; Yao, Leong Jing; Aung, Thet Tun; Shental, Noam; Rotter-Maskowitz, Aviva; Shepherdson, Edwin; Singh, Gurmit Singh Naranjan; Pai, Rhea; Shanti, Adhika; Wong, Regina Men Men; Lee, Andrea; Khyriem, Costerwell; Dutertre, Charles Antoine; Chakarov, Svetoslav; Srinivasan, K G; Shadan, Nurhidaya Binte; Zhang, Xiao-Meng; Khalilnezhad, Shabnam; Cottier, Fabien; Tan, Alrina Shin Min; Low, Gillian; Chen, Phyllis; Fan, Yiping; Hor, Pei Xiang; Lee, Avery Khoo May; Choolani, Mahesh; Vermijlen, David; Sharma, Ankur; Fuks, Garold; Straussman, Ravid; Pavelka, Norman; Malleret, Benoit; McGovern, Naomi; Albani, Salvatore; Chan, Jerry Kok Yen; Ginhoux, Florent.

Cell ; 184(13): 3394-3409.e20, 2021 06 24.

Article in English | MEDLINE | ID: mdl-34077752

3.

Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes.

Riquelme, Erick; Zhang, Yu; Zhang, Liangliang; Montiel, Maria; Zoltan, Michelle; Dong, Wenli; Quesada, Pompeyo; Sahin, Ismet; Chandra, Vidhi; San Lucas, Anthony; Scheet, Paul; Xu, Hanwen; Hanash, Samir M; Feng, Lei; Burks, Jared K; Do, Kim-Anh; Peterson, Christine B; Nejman, Deborah; Tzeng, Ching-Wei D; Kim, Michael P; Sears, Cynthia L; Ajami, Nadim; Petrosino, Joseph; Wood, Laura D; Maitra, Anirban; Straussman, Ravid; Katz, Matthew; White, James Robert; Jenq, Robert; Wargo, Jennifer; McAllister, Florencia.

Cell ; 178(4): 795-806.e12, 2019 08 08.

Article in English | MEDLINE | ID: mdl-31398337

4.

TP53 missense mutations in PDAC are associated with enhanced fibrosis and an immunosuppressive microenvironment.

Maddalena, Martino; Mallel, Giuseppe; Nataraj, Nishanth Belugali; Shreberk-Shaked, Michal; Hassin, Ori; Mukherjee, Saptaparna; Arandkar, Sharathchandra; Rotkopf, Ron; Kapsack, Abby; Lambiase, Giuseppina; Pellegrino, Bianca; Ben-Isaac, Eyal; Golani, Ofra; Addadi, Yoseph; Hajaj, Emma; Eilam, Raya; Straussman, Ravid; Yarden, Yosef; Lotem, Michal; Oren, Moshe.

Proc Natl Acad Sci U S A ; 118(23)2021 06 08.

Article in English | MEDLINE | ID: mdl-34088837

5.

A spatial perspective on bacteria in tumours.

Livyatan, Ilana; Straussman, Ravid.

Nature ; 611(7937): 674-675, 2022 11.

Article in English | MEDLINE | ID: mdl-36385283

6.

High-Throughput Screen Identifies Host and Microbiota Regulators of Intestinal Barrier Function.

Grosheva, Inna; Zheng, Danping; Levy, Maayan; Polansky, Omer; Lichtenstein, Alexandra; Golani, Ofra; Dori-Bachash, Mally; Moresi, Claudia; Shapiro, Hagit; Del Mare-Roumani, Sara; Valdes-Mas, Rafael; He, Yiming; Karbi, Hodaya; Chen, Minhu; Harmelin, Alon; Straussman, Ravid; Yissachar, Nissan; Elinav, Eran; Geiger, Benjamin.

Gastroenterology ; 159(5): 1807-1823, 2020 11.

Article in English | MEDLINE | ID: mdl-32653496

7.

Cytokine sensitivity screening highlights BMP4 pathway signaling as a therapeutic opportunity in ER⁺ breast cancer.

Shee, Kevin; Jiang, Amanda; Varn, Frederick S; Liu, Stephanie; Traphagen, Nicole A; Owens, Philip; Ma, Cynthia X; Hoog, Jeremy; Cheng, Chao; Golub, Todd R; Straussman, Ravid; Miller, Todd W.

FASEB J ; 33(2): 1644-1657, 2019 02.

Article in English | MEDLINE | ID: mdl-30161001

8.

Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion.

Straussman, Ravid; Morikawa, Teppei; Shee, Kevin; Barzily-Rokni, Michal; Qian, Zhi Rong; Du, Jinyan; Davis, Ashli; Mongare, Margaret M; Gould, Joshua; Frederick, Dennie T; Cooper, Zachary A; Chapman, Paul B; Solit, David B; Ribas, Antoni; Lo, Roger S; Flaherty, Keith T; Ogino, Shuji; Wargo, Jennifer A; Golub, Todd R.

Nature ; 487(7408): 500-4, 2012 Jul 26.

Article in English | MEDLINE | ID: mdl-22763439

9.

Temporal Stability of the Healthy Human Skin Microbiome Following Dead Sea Climatotherapy.

Brandwein, Michael; Fuks, Garold; Israel, Avigail; Al-Ashhab, Ashraf; Nejman, Deborah; Straussman, Ravid; Hodak, Emmilia; Harari, Marco; Steinberg, Doron; Bentwich, Zvi; Shental, Noam; Meshner, Shiri.

Acta Derm Venereol ; 98(2): 256-261, 2018 Feb 07.

Article in English | MEDLINE | ID: mdl-28815268

10.

Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer.

Schlesinger, Yeshayahu; Straussman, Ravid; Keshet, Ilana; Farkash, Shlomit; Hecht, Merav; Zimmerman, Joseph; Eden, Eran; Yakhini, Zohar; Ben-Shushan, Etti; Reubinoff, Benjamin E; Bergman, Yehudit; Simon, Itamar; Cedar, Howard.

Nat Genet ; 39(2): 232-6, 2007 Feb.

Article in English | MEDLINE | ID: mdl-17200670

11.

Competitive fungal commensalism mitigates candidiasis pathology.

Sekeresova Kralova, Jarmila; Donic, Catalina; Dassa, Bareket; Livyatan, Ilana; Jansen, Paul Mathias; Ben-Dor, Shifra; Fidel, Lena; Trzebanski, Sébastien; Narunsky-Haziza, Lian; Asraf, Omer; Brenner, Ori; Dafni, Hagit; Jona, Ghil; Boura-Halfon, Sigalit; Stettner, Noa; Segal, Eran; Brunke, Sascha; Pilpel, Yitzhak; Straussman, Ravid; Zeevi, David; Bacher, Petra; Hube, Bernhard; Shlezinger, Neta; Jung, Steffen.

J Exp Med ; 221(5)2024 May 06.

Article in English | MEDLINE | ID: mdl-38497819

12.

A clinical evaluation of an ex vivo organ culture system to predict patient response to cancer therapy.

Golan, Shay; Bar, Vered; Salpeter, Seth J; Neev, Guy; Creiderman, German; Kedar, Daniel; Aharon, Sara; Turovsky, Lubov; Zundelevich, Adi; Shahar, Hamutal; Shapira, Hagit; Mallel, Giuseppe; Stossel, Erez; Gavert, Nancy; Straussman, Ravid; Dotan, Zohar; Berger, Raanan; Stossel, Chani; Golan, Talia; Halperin, Sharon; Leibovici, Dan; Breuer, Shani; Rottenberg, Yakir; Applebaum, Liat; Hubert, Ayala; Nechushtan, Hovav; Peretz, Tamar; Zick, Aviad; Chertin, Boris; Koulikov, Dmitry; Sonnenblick, Amir; Rosenbaum, Eli.

Front Med (Lausanne) ; 10: 1221484, 2023.

Article in English | MEDLINE | ID: mdl-37840996

13.

Spectrum of Response to Platinum and PARP Inhibitors in Germline BRCA-Associated Pancreatic Cancer in the Clinical and Preclinical Setting.

Stossel, Chani; Raitses-Gurevich, Maria; Atias, Dikla; Beller, Tamar; Glick Gorman, Yulia; Halperin, Sharon; Peer, Eyal; Denroche, Robert E; Zhang, Amy; Notta, Faiyaz; Wilson, Julie M; O'Kane, Grainne M; Haimov Talmoud, Elina; Amison, Nora; Schvimer, Michael; Salpeter, Seth J; Bar, Vered; Zundelevich, Adi; Tirosh, Itay; Tal, Rotem; Dinstag, Gal; Kinar, Yaron; Eliezer, Yonatan; Ben-David, Uri; Gavert, Nancy S; Straussman, Ravid; Gallinger, Steven J; Berger, Raanan; Golan, Talia.

Cancer Discov ; 13(8): 1826-1843, 2023 08 04.

Article in English | MEDLINE | ID: mdl-37449843

14.

Compartmentalization of the host microbiome: how tumor microbiota shapes checkpoint immunotherapy outcome and offers therapeutic prospects.

Boesch, Maximilian; Horvath, Lena; Baty, Florent; Pircher, Andreas; Wolf, Dominik; Spahn, Stephan; Straussman, Ravid; Tilg, Herbert; Brutsche, Martin H.

J Immunother Cancer ; 10(11)2022 11.

Article in English | MEDLINE | ID: mdl-36343977

15.

Visual barcodes for clonal-multiplexing of live microscopy-based assays.

Kaufman, Tom; Nitzan, Erez; Firestein, Nir; Ginzberg, Miriam Bracha; Iyengar, Seshu; Patel, Nish; Ben-Hamo, Rotem; Porat, Ziv; Hunter, Jaryd; Hilfinger, Andreas; Rotter, Varda; Kafri, Ran; Straussman, Ravid.

Nat Commun ; 13(1): 2725, 2022 05 18.

Article in English | MEDLINE | ID: mdl-35585055

16.

Ex vivo organotypic cultures for synergistic therapy prioritization identify patient-specific responses to combined MEK and Src inhibition in colorectal cancer.

Gavert, Nancy; Zwang, Yaara; Weiser, Roi; Greenberg, Orli; Halperin, Sharon; Jacobi, Oded; Mallel, Giuseppe; Sandler, Oded; Berger, Adi Jacob; Stossel, Erez; Rotin, Daniil; Grinshpun, Albert; Kamer, Iris; Bar, Jair; Pines, Guy; Saidian, Daniel; Bar, Ilan; Golan, Shay; Rosenbaum, Eli; Nadu, Andrei; Ben-Ami, Eytan; Weitzen, Rony; Nechushtan, Hovav; Golan, Talia; Brenner, Baruch; Nissan, Aviram; Margalit, Ofer; Hershkovitz, Dov; Lahat, Guy; Straussman, Ravid.

Nat Cancer ; 3(2): 219-231, 2022 02.

Article in English | MEDLINE | ID: mdl-35145327

17.

Genome-wide de novo methylation in epithelial ovarian cancer.

Michaelson-Cohen, Rachel; Keshet, Ilana; Straussman, Ravid; Hecht, Merav; Cedar, Howard; Beller, Uziel.

Int J Gynecol Cancer ; 21(2): 269-79, 2011 Feb.

Article in English | MEDLINE | ID: mdl-21270610

18.

Microbiome and cancer.

Cullin, Nyssa; Azevedo Antunes, Camila; Straussman, Ravid; Stein-Thoeringer, Christoph K; Elinav, Eran.

Cancer Cell ; 39(10): 1317-1341, 2021 10 11.

Article in English | MEDLINE | ID: mdl-34506740

19.

The microbiome and human cancer.

Sepich-Poore, Gregory D; Zitvogel, Laurence; Straussman, Ravid; Hasty, Jeff; Wargo, Jennifer A; Knight, Rob.

Science ; 371(6536)2021 03 26.

Article in English | MEDLINE | ID: mdl-33766858

20.

IRS1 phosphorylation underlies the non-stochastic probability of cancer cells to persist during EGFR inhibition therapy.

Jacob Berger, Adi; Gigi, Elinor; Kupershmidt, Lana; Meir, Zohar; Gavert, Nancy; Zwang, Yaara; Prior, Amir; Gilad, Shlomit; Harush, Uzi; Haviv, Izhak; Stemmer, Salomon M; Blum, Galia; Merquiol, Emmanuelle; Mardamshina, Mariya; Kaminski Strauss, Sivan; Friedlander, Gilgi; Bar, Jair; Kamer, Iris; Reizel, Yitzhak; Geiger, Tamar; Pilpel, Yitzhak; Levin, Yishai; Tanay, Amos; Barzel, Baruch; Reuveni, Hadas; Straussman, Ravid.

Nat Cancer ; 2(10): 1055-1070, 2021 10.

Article in English | MEDLINE | ID: mdl-35121883

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