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1.
Pantothenate Kinase Activation Restores Brain Coenzyme A in a Mouse Model of Pantothenate Kinase-Associated Neurodegeneration.
J Pharmacol Exp Ther
; 388(1): 171-180, 2024 01 02.
Article
in English
| MEDLINE | ID: mdl-37875310
2.
Relief of CoA sequestration and restoration of mitochondrial function in a mouse model of propionic acidemia.
J Inherit Metab Dis
; 46(1): 28-42, 2023 01.
Article
in English
| MEDLINE | ID: mdl-36251252
3.
LipE guided discovery of isopropylphenyl pyridazines as pantothenate kinase modulators.
Bioorg Med Chem
; 52: 116504, 2021 12 15.
Article
in English
| MEDLINE | ID: mdl-34814071
4.
Metabolic activation of CaMKII by coenzyme A.
Mol Cell
; 52(3): 325-39, 2013 Nov 07.
Article
in English
| MEDLINE | ID: mdl-24095281
5.
In Vivo and In Vitro Effects of a ClpP-Activating Antibiotic against Vancomycin-Resistant Enterococci.
Antimicrob Agents Chemother
; 62(8)2018 08.
Article
in English
| MEDLINE | ID: mdl-29784838
6.
Discovery of an L-alanine ester prodrug of the Hsp90 inhibitor, MPC-3100.
Bioorg Med Chem Lett
; 25(22): 5254-7, 2015 Nov 15.
Article
in English
| MEDLINE | ID: mdl-26483201
7.
Discovery of novel bacterial elongation condensing enzyme inhibitors by virtual screening.
Bioorg Med Chem Lett
; 24(11): 2585-8, 2014 Jun 01.
Article
in English
| MEDLINE | ID: mdl-24755430
8.
Biophysical analysis of the Mycobacteria tuberculosis peptide binding protein DppA reveals a stringent peptide binding pocket.
Tuberculosis (Edinb)
; 132: 102157, 2022 01.
Article
in English
| MEDLINE | ID: mdl-34894561
9.
Pantothenate kinase activation relieves coenzyme A sequestration and improves mitochondrial function in mice with propionic acidemia.
Sci Transl Med
; 13(611): eabf5965, 2021 Sep 15.
Article
in English
| MEDLINE | ID: mdl-34524863
10.
Ureadepsipeptides as ClpP Activators.
ACS Infect Dis
; 5(11): 1915-1925, 2019 11 08.
Article
in English
| MEDLINE | ID: mdl-31588734
11.
Discovery of novel isoxazolines as anti-tuberculosis agents.
Bioorg Med Chem Lett
; 17(23): 6638-42, 2007 Dec 01.
Article
in English
| MEDLINE | ID: mdl-17937983
12.
Synthesis and evaluation of cyclic secondary amine substituted phenyl and benzyl nitrofuranyl amides as novel antituberculosis agents.
J Med Chem
; 48(26): 8261-9, 2005 Dec 29.
Article
in English
| MEDLINE | ID: mdl-16366608
13.
Synthesis and evaluation of nitrofuranylamides as novel antituberculosis agents.
J Med Chem
; 47(21): 5276-83, 2004 Oct 07.
Article
in English
| MEDLINE | ID: mdl-15456272
14.
Discovery of (2S)-1-[4-(2-{6-amino-8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-9-yl}ethyl)piperidin-1-yl]-2-hydroxypropan-1-one (MPC-3100), a purine-based Hsp90 inhibitor.
J Med Chem
; 55(17): 7480-501, 2012 Sep 13.
Article
in English
| MEDLINE | ID: mdl-22913511
15.
Synthesis, optimization and structure-activity relationships of 3,5-disubstituted isoxazolines as new anti-tuberculosis agents.
Eur J Med Chem
; 44(2): 460-72, 2009 Feb.
Article
in English
| MEDLINE | ID: mdl-18524421
16.
Pharmacokinetically-guided lead optimization of nitrofuranylamide anti-tuberculosis agents.
AAPS J
; 10(1): 157-65, 2008.
Article
in English
| MEDLINE | ID: mdl-18446516
17.
Nitrofurans as novel anti-tuberculosis agents: identification, development and evaluation.
Curr Top Med Chem
; 7(5): 509-26, 2007.
Article
in English
| MEDLINE | ID: mdl-17346196
18.
Synthesis of new and potent analogues of anti-tuberculosis agent 5-nitro-furan-2-carboxylic acid 4-(4-benzyl-piperazin-1-yl)-benzylamide with improved bioavailability.
Bioorg Med Chem Lett
; 16(10): 2584-9, 2006 May 15.
Article
in English
| MEDLINE | ID: mdl-16529927
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