Network analysis studies in patients with eating disorders: A systematic review and methodological quality assessment.

INTRODUCTION: Network psychometrics has been enthusiastically embraced by researchers studying eating disorders (ED), but a rigorous evaluation of the methodological quality of works is still missing. This systematic review aims to assess the methodological quality of cross-sectional network analysis (NA) studies conducted on ED clinical populations. METHODS: PRISMA and PICOS criteria were used to retrieve NA studies on ED. Methodological quality was evaluated based on five criteria: variable-selection procedure, network estimation method, stability checks, topological overlap checks, and handling of missing data. RESULTS: Thirty-three cross-sectional NA studies were included. Most studies focused on populations that were female, white and, with an anorexia nervosa (AN) diagnosis. Depending on how many criteria were satisfied, 27.3% of studies (n = 9) were strictly adherent, 30.3% (n = 10) moderately adherent, 33.3% (n = 11) sufficiently adherent, and 9.1% (n = 3) poorly adherent. Missing topological overlap checks and not reporting missing data represented most unreported criteria, lacking, respectively, in 63.6% and 48.5% of studies. CONCLUSIONS: Almost all reviewed cross-sectional NA studies on ED report those methodological procedures (variable-selection procedure, network estimation method, stability checks) necessary for a network study to provide reliable results. Nonetheless these minimum reporting data require further improvement. Moreover, elements closely related to the validity of an NA study (controls for topological overlap and management of missing data) are lacking in most studies. Recommendations to overcome such methodological weaknesses in future NA studies on ED are discussed together with the need to conduct NA studies with longitudinal design, to address diversity issues in study samples and heterogeneity of assessment tools. PUBLIC SIGNIFICANCE: The present work aims to evaluate the quality of ED NA studies to support applications of this approach in ED research. Results show that most studies adopted basic procedures to produce reliable results; however, other important procedures linked to NA study validity were mostly neglected. Network methodology in ED is extremely promising, but future studies should consistently include topological overlap control procedures and provide information on missing data.

INTRODUCCIÓN: La psicometría de red ha sido aceptada con entusiasmo por los investigadores que estudian los trastornos de la conducta alimentaria (TCA), pero aún falta una evaluación rigurosa de la calidad metodológica de los trabajos. Esta revisión sistemática tiene como objetivo evaluar la calidad metodológica de los estudios de análisis de redes transversales (NA) realizados en poblaciones clínicas de TCA. MÉTODOS: Se utilizaron los criterios PRISMA y PICOS para recuperar los estudios de NA en TCA. La calidad metodológica se evaluó con base en 5 criterios: procedimiento de selección de variables, método de estimación de red, comprobaciones de estabilidad, comprobaciones de superposición topológica, manejo de datos faltantes. RESULTADOS: Se incluyeron 33 estudios transversales de NA. La mayoría de los estudios se centraron en poblaciones que eran mujeres, blancas y con un diagnóstico de anorexia nerviosa (AN). Dependiendo de cuántos criterios se cumplieron, el 27,3% de los estudios (n = 9) fueron estrictamente adherentes, el 30,3% (n = 10) moderadamente adherentes, el 33,3% (n = 11) suficientemente adherentes, el 9,1% (n = 3) poco adherentes. La falta de controles topológicos de superposición y el no reportar los datos faltantes representó la mayoría de los criterios no reportados, faltando respectivamente en el 63,6% y el 48,5% de los estudios. CONCLUSIONES: Casi todos los estudios transversales revisados de NA sobre TCA reportaron aquellos procedimientos metodológicos (procedimiento de selección de variables, método de estimación de red, comprobaciones de estabilidad) necesarios para que un estudio de red proporcione resultados confiables. No obstante, estos datos mínimos de presentación de reportes requieren mejoras adicionales. Además, en la mayoría de los estudios faltan elementos estrechamente relacionados con la validez de un estudio de NA (controles para la superposición topológica y el manejo de los datos faltantes). Las recomendaciones para superar tales debilidades metodológicas en futuros estudios de NA sobre los TCA son discutidos junto con la necesidad de realizar estudios de NA con diseño longitudinal, para abordar los problemas de diversidad en las muestras de estudio y la heterogeneidad de las herramientas de evaluación.

Residual eating disorder symptoms and clinical features in remitted and recovered eating disorder patients: A systematic review with meta-analysis.

OBJECTIVE: In psychiatry, the presence of residual symptoms after treatment is linked to the definitions of remission and recovery. To identify the presence of residual eating disorder (ED) symptoms and associated non-ED clinical features in remitted and recovered EDs, the current systematic review with meta-analysis was performed. METHOD: A systematic review was conducted on residual ED symptoms and non-ED clinical features including comorbid psychopathology, neurophysiological functioning, cognitive functioning, and quality of life in ED patients considered remitted or recovered. To examine residual ED symptoms, meta-analyses were performed while considering age, study quality, remission, and recovery criteria strictness as moderators. Sensitivity, publication bias, and heterogeneity analyses were also conducted. RESULTS: The 64 studies selected for the systematic review underscored the presence of residual ED symptoms in anorexia nervosa (AN) and bulimia nervosa (BN), and impairments and deficits in the additional features examined. From the 64 studies, 31 were selected regarding residual ED symptoms in AN for meta-analysis. Large effect sizes indicated that remitted/recovered AN patients reported significantly lower body mass index (Hedges' g = -0.62[-0.77, -0.46]) and significantly greater symptomatology in terms of ED examination-questionnaire (Hedges'g = 0.86 [0.48,1.23]) and ED inventory (Hedges' g = 0.94[0.64,1.24]) than healthy controls, independently of remission and recovery criteria strictness, age, and study quality. DISCUSSION: The presence of residual ED symptoms in AN is quantitatively supported, whereas the presence of residual ED symptoms in BN should be further investigated. Data on binge-eating disorder are missing. Future research should use consistent, multicomponent, and standardized comparable indicators of recovery.

OBJETIVO: En psiquiatría, la presencia de síntomas residuales después de tratamiento está ligado a las definiciones de remisión y recuperación. Para identificar la presencia de síntomas residuales del trastorno de la conducta alimentaria (TCA) y características clínicas no de TCA asociadas en pacientes remitidos y recuperados de TCAs, se realizó la presente revisión sistemática con meta-análisis. MÉTODO: Se realizó una revisión sistemática en síntomas residuales de TCA y en características clínicas no de TCA incluyendo psicopatología comórbida, funcionamiento neurofisiológico, funcionamiento cognitivo, y calidad de vida en pacientes con TCA considerados remitidos o recuperados. Para examinar los síntomas residuales de TCA se realizaron meta-análisis considerando edad, calidad del estudio, criterios de remisión y recuperación estrictos como moderadores. También se realizaron análisis de sensibilidad, sesgo de publicación y heterogenicidad. RESULTADOS: Los 64 estudios seleccionados para la revisión sistemática destacaron la presencia de síntomas residuales de TCA en anorexia nervosa (AN) y bulimia nervosa (BN), y alteraciones y déficits en las características adicionales examinadas. De los 64 estudios, 31 fueron seleccionados para meta-análisis por los síntomas residuales de TCA en AN. Las medidas de efecto mayor indicaron que los pacientes remitidos/recuperados de AN reportaron índices de masa corporal significativamente menores (Hedges' g = -0.62[-0.77,-0.46]) y significativamente mayor sintomatología en términos del Cuestionario de Evaluación de TCA (Eating Disorder Examination-Questionnaire) (Hedges' g = 0.86 19 [0.48,1.23]) y el Inventario de TCA (Eating Disorder Inventory) (Hedges' g= 0.94[0.64,1.24]) que los controles sanos, independientemente de lo estricto de los criterios de remisión y recuperación, edad y calidad del estudio. DISCUSIÓN: La presencia de síntomas residuales de TCA en AN es apoyada cuantitativamente, mientras que la presencia de síntomas residuales de TCA en BN necesita ser investigada a mayor profundidad. Los datos en trastorno de atracones están ausentes. Las investigaciones futuras deberían utilizar indicadores de recuperación consistentes, de múltiples componentes y estandarizados.

Bridging Perspectives: Exploring the Convergence of Clinimetrics and Network Theory in Mental Health Assessment and Conceptualization.

Background: Clinimetrics and network analysis are two methodological approaches that, despite different origins, share the goal of improving mental health clinical assessment beyond the limitations of classical psychometrics. Despite their common goal and comparable conceptualization of clinical assessment, the potential connection and integration between these approaches has not been explored. The aim of this review is to identify meeting points for the potential integration of clinimetrics and network theory. Methods: A literature review was conducted by examining key works in clinimetrics and network theory and comparing similar concepts from the two approaches. Results: Two main areas of theoretical and methodological convergence and complementarity between clinimetrics and network theory were identified, as follows: the characteristics of clinical indexes and the strategies to assess and organize complex clinical data. These topics encompassed sub-topics related to the influence of individual symptoms on clinical presentation, longitudinal assessment of conditions, influence of comorbidities, and standardized procedures for case formulation. Conclusions: Results provide an indication of the potential for integration for these approaches in a single, clinically oriented methodology for psychological and psychiatric illness conceptualization and assessment. Despite the literature search strategy limitations, the results provide a basis for further exploring the potential for developing an integrated methodology for clinical assessment and treatment planning.

Mapping the Path to Cognitive Balance: Applying the States of Mind Model and Network Analysis to Eating Disorder Patients.

Background: In eating disorders (EDs), cognitive-behavioral therapy (CBT) represents one of the first-line treatment options albeit with sub-optimal results. The assessment of cognitive balance through an index measuring increased adaptive thinking and reduced maladaptive thinking, the desired outcomes, and the ultimate goal of CBT treatments warrants attention. The states of mind model (SOM) provides a framework through which a cognitive balance index can be defined. The current cross-sectional controlled study tested the clinical utility of the SOM model in a sample of ED outpatients. Methods: ED outpatients (n = 199) were assessed at baseline with the attitudes and beliefs scale-2 (ABS-2) for rational beliefs (RBs) and irrational beliefs (IBs), from which a SOM ratio score index (RBs/(RBs + IBs)) was calculated, the eating disorder inventory-3 (EDI-3) for ED symptoms and ED-related psychopathological features, the psychological well-being scales (PWB) for positive psychological functioning. A matched control sample (n = 95) was also assessed with the ABS-2. Results: ED patients exhibited significantly lower SOM and RB scores compared to controls. Network analysis results highlighted the centrality of the SOM-cognitive balance index, PWB-self-acceptance, and EDI-3-general psychological maladjustment, as well as the importance of the influence that cognitive balance and general psychological maladjustment exert on each other. Conclusions: The findings support the clinical utility of the SOM ratio applied to cognitions in EDs. This demonstrates its ability to differentiate such patients from controls and in capturing worse ED-related general psychopathology as well as compromised aspects of psychological well-being, in particular self-acceptance and environmental mastery. It thus might be considered in CBT treatment of EDs a potential cognitive clinimetric and clinical index of ED severity indicating key difficulties in counteracting maladaptive thinking with adaptive thinking.

Intravenous immunoglobulin and rituximab versus placebo treatment of antibody-associated psychosis: study protocol of a randomised phase IIa double-blinded placebo-controlled trial (SINAPPS2).

BACKGROUND: Evidence is conflicting about a causal role of inflammation in psychosis and, specifically, regarding antibodies binding to neuronal membrane targets, especially N-methyl-D-aspartate receptors. NMDAR, LGI1 and GABA-A antibodies were found more prevalent in people with psychosis than in healthy controls. We aim to test whether these antibodies are pathogenic and may cause isolated psychosis. The SINAPPS2 phase IIa double-blinded randomised controlled trial will test the efficacy and safety of immunoglobulin and rituximab treatment versus placebo for patients with acute psychosis symptoms as added to psychiatric standard of care. METHODS: We will screen approximately 2500 adult patients with acute psychosis to identify 160 with antibody-positive psychosis without co-existing neurological disease and recruit about 80 eligible participants to the trial in the period from September 2017 to September 2021 across the UK. Eligible patients will be randomised 1:1 either to intravenous immunoglobulin (IVIG) followed by rituximab or to placebo infusions of 1% albumin followed by 0.9% sodium chloride, respectively. To detect a time-to-symptomatic-recovery hazard ratio of 0.322 with a power of 80%, 56 participants are needed to complete the trial, allowing for up to 12 participants to drop out of each group. Eligible patients will be randomised and assessed at baseline within 4 weeks of their eligibility confirmation. The treatment will start with IVIG or 1% albumin placebo infusions over 2-4 consecutive days no later than 7 days from baseline. It will continue 4-5 weeks later with a rituximab or sodium chloride placebo infusion and will end 2-3 weeks after this with another rituximab or placebo infusion. The primary outcome is the time to symptomatic recovery defined as symptomatic remission sustained for at least 6 months on the following Positive and Negative Syndrome Scale items: P1, P2, P3, N1, N4, N6, G5 and G9. Participants will be followed for 12 months from the first day of treatment or, where sustained remission begins after the first 6 months, for an additional minimum of 6 months to assess later response. DISCUSSION: The SINAPPS2 trial aims to test whether immunotherapy is efficacious and safe in psychosis associated with anti-neuronal membrane antibodies. TRIAL REGISTRATION: ISRCTN, 11177045. Registered on 2 May 2017. EudraCT, 2016-000118-31. Registered on 22 November 2016. ClinicalTrials.gov, NCT03194815. Registered on 21 June 2017.