ABSTRACT
The introduction of optical coherence tomography angiography (OCT-A) has generated interest in evaluating vascular dysfunctions in the optic nerve head for the diagnosis and monitoring of glaucoma. The purpose of this study is to compare perfusion of the optic disc between normal subjects and subjects with glaucoma using OCT-A in order to detect changes in perfusion of the optic disc. Using the OCT-A AngioVue® system, an examination was performed on 40 eyes of 40 patients (20 with glaucoma and 20 healthy controls). Total radial peripapillary flow density (4.5×4.5mm) was measured at different levels of segmentation. The study demonstrated that the peripapillary vascular flow of OCT-A and exploration of the optic nerve head was better in the normal eyes compared to glaucoma patients. This review provides a comprehensive summary of the most important current and potential applications of OCT-A in glaucoma.
ABSTRACT
PURPOSE: To determine whether intravitreal injection of plasmin is effective in treating diffuse diabetic macular edema (DDME). DESIGN: A prospective, comparative, interventional case study. PATIENTS: Eighteen patients with bilateral DDME received, as their primary therapeutic treatment, an intravitreal injection of plasmin in one eye, with their contralateral untreated eye serving as a control. INTERVENTION: Intravitreal 0.2 ml of autologous plasmin injected under topical anesthesia. The plasmin was obtained by a simplified method. MAIN OUTCOME MEASURES: Central macular thickness (CMT), determined by optical coherence tomography (OCT), and Best Corrected Visual Acuity (LogMAR), assessed at one and three months of follow-up. RESULTS: All patients completed the 3-month follow-up assessments. Before the injection, the CMT was 525.22 SD 80.12 microm [mean +/- standard deviation (SD)] in the eyes to be injected, compared to 525.44 SD 78.13 microm in the control eyes. One month after the injection, the CMT was 323.72 SD 44.87 microm in the injected eyes and 518.44 SD 78.54 microm in the control eyes (P < 0.001, bilateral Wilcoxon test for paired samples). Three months after the injection, the CMT was 310.55 SD 35.38 microm in the injected eyes and 517.66 SD 80 microm in the control eyes (P < 0.001). Macular edema improved in all injected eyes (100%), with a reduction of at least 50% in every treated eye, but no changes occurred in the control group. Nine of the 18 treated eyes (50%) improved their BCVA by at least two vision lines. No adverse effects were observed in any of the patients. CONCLUSION: Intravitreal plasmin injection, as primary treatment, effectively reduces macular thickening due to DDME and improves visual acuity. Further studies are warranted to assess long-term efficacy and safety.
Subject(s)
Diabetic Retinopathy/drug therapy , Fibrinolysin/administration & dosage , Macular Edema/drug therapy , Vitrectomy/methods , Aged , Aged, 80 and over , Female , Humans , Injections , Male , Middle Aged , Pilot Projects , Prospective Studies , Vitreous BodyABSTRACT
CASE REPORT: A 53 year-old woman with a stage 2 macular hole received ocriplasmin injection as a first approach. She subsequently underwent pars plana vitrectomy due to enlargement of the hole post-injection. The visual gain following the surgery was minimal despite closure of the hole. This could be explained by outer retina atrophy as a consequence of potential toxic mechanisms related to ocriplasmin. DISCUSSION: Further studies may be warranted to fully understand the impact of ocriplasmin on long-term visual function.
Subject(s)
Fibrinolysin/adverse effects , Peptide Fragments/adverse effects , Retinal Diseases/chemically induced , Female , Fibrinolysin/therapeutic use , Humans , Middle Aged , Peptide Fragments/therapeutic use , Retinal Perforations/drug therapy , Treatment FailureSubject(s)
Fluorescein Angiography , Microscopy, Acoustic , Multimodal Imaging , Tomography, Optical Coherence , Tuberculosis, Ocular/diagnostic imaging , Uveitis, Intermediate/diagnostic imaging , Adult , Female , Humans , Macular Edema/diagnostic imaging , Macular Edema/etiology , Tuberculosis, Ocular/complications , Uveitis, Intermediate/complicationsSubject(s)
Angiogenesis Inhibitors/therapeutic use , Macula Lutea/pathology , Macular Edema/pathology , Retinal Vein Occlusion/drug therapy , Angiogenesis Inhibitors/administration & dosage , Antibodies, Monoclonal/therapeutic use , Antibodies, Monoclonal, Humanized , Aptamers, Nucleotide/therapeutic use , Drug Monitoring , Humans , Injections , Macular Edema/etiology , Prognosis , Ranibizumab , Recurrence , Retinal Vein Occlusion/complications , Vitreous BodySubject(s)
Contact Lenses , Lenses, Intraocular , Medical Errors , Refraction, Ocular , Biometry/methods , Female , Humans , Middle Aged , Refractive ErrorsSubject(s)
Bevacizumab/economics , Cost-Benefit Analysis , Diabetic Retinopathy/economics , Macular Edema/economics , Ranibizumab/economics , Recombinant Fusion Proteins/economics , Bevacizumab/therapeutic use , Diabetic Retinopathy/drug therapy , Humans , Macular Edema/drug therapy , Ranibizumab/therapeutic use , Receptors, Vascular Endothelial Growth Factor/therapeutic use , Recombinant Fusion Proteins/therapeutic use , SpainABSTRACT
La introducción de la angiografía por tomografía de coherencia óptica (OCT-A) ha generado interés en evaluar las alteraciones vasculares en la cabeza del nervio óptico para el diagnóstico y monitorización del glaucoma. El propósito de este estudio es comparar la perfusión del disco óptico entre sujetos normales y sujetos con glaucoma usando OCT-A para detectar cambios en la perfusión del disco óptico. El sistema OCTA AngioVue examinó 40 ojos de 40 pacientes (20 con glaucoma y 20 controles sanos). La densidad de flujo peripapilar radial total (4,5×4,5mm) se midió en diferentes niveles de segmentación. El estudio demostró que el flujo vascular peripapilar de la OCT-A y la exploración de la cabeza del nervio óptico fue mejor en los ojos normales en comparación con los pacientes con glaucoma. Esta revisión proporciona un resumen exhaustivo de las aplicaciones actuales y potenciales más importantes de OCTA en el glaucoma (AU)
The introduction of optical coherence tomography angiography (OCT-A) has generated interest in evaluating vascular dysfunctions in the optic nerve head for the diagnosis and monitoring of glaucoma. The purpose of this study is to compare perfusion of the optic disc between normal subjects and subjects with glaucoma using OCT-A in order to detect changes in perfusion of the optic disc. Using the OCT-A AngioVue® system, an examination was performed on 40 eyes of 40 patients (20 with glaucoma and 20 healthy controls). Total radial peripapillary flow density (4.5×4.5mm) was measured at different levels of segmentation. The study demonstrated that the peripapillary vascular flow of OCT-A and exploration of the optic nerve head was better in the normal eyes compared to glaucoma patients. This review provides a comprehensive summary of the most important current and potential applications of OCT-A in glaucoma (AU)
Subject(s)
Humans , Male , Female , Adult , Middle Aged , Glaucoma/diagnostic imaging , Optic Nerve/diagnostic imaging , Computed Tomography Angiography , Tomography, Optical Coherence , Case-Control StudiesABSTRACT
Q Fever is a zoonosis caused by Coxiella burnetii. Ocular manifestations are rare in this infection. We describe the case of a man complaining of an intense retro-orbital headache, fever, arthralgia, and bilateral loss of vision, who showed an anterior uveitis accompanied by exudative bilateral inferior retinal detachment and optic disk edema. At the beginning, a Vogt-Koyanagi-Harada (VKH) syndrome was suspected, but the patient was diagnosed with Q fever and treatment with doxycycline was initiated, with complete resolution after 2 weeks. We wondered if Q fever could unleash VKH syndrome or simulate a VKH syndrome by a similar immunological process.
ABSTRACT
No disponible