ABSTRACT
Diabetes mellitus is a growing concern worldwide and leads to multiple complications during pregnancy. Pharmacologic doses of chromium (Cr) have been linked with improving insulin sensitivity and other positive benefits in the treatment of diabetes in animal models. By using streptozotocin induced hyperglycemia in female CD-1 mice, reproductive outcomes of diabetic and chromium-dosed diabetic females were examined. After dosing 10 mg/kg Cr in the form of triaqua-µ3 -oxo-hexa-µ-propionatotrichromium(III) chloride or Cr3 during gestation days 8-16 (GD8-GD16), all females were sacrificed on gestation day 17 (GD17) and examined for maternal weight gain. The fetuses were examined for gross malformations and for skeletal malformations. The offspring of Cr3-dosed females tended to have a reduction in the incidence of supernumerary ribs. While hyperglycemia still had negative impacts on the health of dams and their offspring, administration of Cr led to an apparent trend in the reduction in the number of malformations and incidence of supernumerary ribs compared to those of untreated diabetic mothers.
Subject(s)
Congenital Abnormalities/prevention & control , Diabetes Complications/prevention & control , Diabetes Mellitus, Experimental/drug therapy , Embryonic Development/drug effects , Fetal Development/drug effects , Organometallic Compounds/pharmacology , Pregnancy in Diabetics/drug therapy , Animals , Blood Glucose/metabolism , Congenital Abnormalities/etiology , Diabetes Complications/etiology , Diabetes Mellitus, Experimental/complications , Diabetes Mellitus, Experimental/pathology , Dose-Response Relationship, Drug , Female , Fetus/drug effects , Fetus/pathology , Insulin/metabolism , Male , Maternal Exposure , Mice , Pregnancy , Pregnancy in Diabetics/pathologyABSTRACT
This JAMA Forum discusses enhancing civic engagement in the US and provides examples of how health equity leaders can help promote civic engagement in communities with health disparities.