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1.
J Cutan Pathol ; 50(5): 420-424, 2023 May.
Article in English | MEDLINE | ID: mdl-36764679

ABSTRACT

The association between acanthosis nigricans (AN) and mycosis fungoides (MF) has rarely been described, but it is known that MF may appear as AN-like vegetating and papillomatous plaques in skin folds, or may be associated with paraneoplastic AN. There have also been recent descriptions of a form of "intertriginous MF" that is characterized by skin fold involvement and the expression of T follicular helper (TFH) markers, and that often has an aggressive course. We describe the case of a 48-year-old man affected by MF associated with AN, whose lesions were characterized by a TFH immunophenotype and the expression of the GATA-3 nuclear master regulator that may be related to a TFH-2 subpopulation or possible disease progression.


Subject(s)
Acanthosis Nigricans , Mycosis Fungoides , Skin Neoplasms , Humans , Acanthosis Nigricans/complications , Acanthosis Nigricans/pathology , Skin Neoplasms/pathology , Mycosis Fungoides/pathology , Phenotype , T-Lymphocytes, Helper-Inducer/pathology
2.
Australas J Dermatol ; 63(4): 509-512, 2022 Nov.
Article in English | MEDLINE | ID: mdl-35877187

ABSTRACT

Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE), previously termed drug-related baboon syndrome, is an uncommon drug eruption. It is characterized by symmetrical erythema involving the gluteal and/or inguinal area in association with one other intertriginous area in the absence of systemic involvement. It typically develops a few hours to days after drug exposure. The diagnosis is based on clinical presentation and drug history. The treatment consists mainly of withdrawal of the causative agent; corticosteroids (topical or systemic) are prescribed to accelerate the resolution. We present three cases that appeared after proton-pump inhibitors (PPIs) intake.


Subject(s)
Drug Eruptions , Exanthema , Intertrigo , Humans , Proton Pump Inhibitors/adverse effects , Drug Eruptions/diagnosis , Exanthema/chemically induced , Exanthema/drug therapy , Intertrigo/chemically induced , Intertrigo/complications , Erythema/complications
3.
Hematol Oncol ; 39(3): 275-283, 2021 Aug.
Article in English | MEDLINE | ID: mdl-33855728

ABSTRACT

In this paper, we present a review of critical concepts, and produce recommendations on management issues in cutaneous T-cell lymphomas (CTCLs) of adults. A panel of nine experts was selected for their expertise in research and clinical practice of CTCLs. During an initial meeting, the areas of major concern in the management of CTCLs were selected by generating and rank-ordering clinical key questions using the criterion of clinical relevance, through group discussion. Recommendations were achieved by multiple-step formalized procedures to reach a consensus after a comprehensive analysis of the scientific literature. The panel produced recommendations on how to facilitate the clinical suspicion of CTCL; indication of cutaneous biopsy; optimal histological diagnosis, immunohistochemistry and genetic markers; and staging pathway and up-to-date therapeutics (with particular focus on new treatments). The critical concept of integration of the different medical expertise in the management of the patients with CTCL was thoroughly examined. These recommendations are intended for use not only by expert centers but above all by "not experienced" dermatologists and hematologists as well as general practitioners.


Subject(s)
Consensus , Lymphoma, T-Cell, Cutaneous , Adult , Biomarkers, Tumor/genetics , Female , Humans , Italy , Lymphoma, T-Cell, Cutaneous/diagnosis , Lymphoma, T-Cell, Cutaneous/genetics , Lymphoma, T-Cell, Cutaneous/therapy
5.
Virchows Arch ; 2023 Oct 23.
Article in English | MEDLINE | ID: mdl-37870613

ABSTRACT

Extranodal NK/T-cell lymphoma (ENKTL) is a rare lymphoma subtype associated with Epstein-Barr virus (EBV) infection, portending a poor prognosis despite systemic chemotherapy. We present the unusual case of an 85-year-old man receiving ibrutinib for mantle cell lymphoma, who developed a erythematous, subcutaneous nodule on the forehead, featuring a proliferation of pleomorphic CD8 + /CD56 - /EBV + cells. Given the negative staging and comorbidities, a watchful waiting strategy was performed, experiencing a benign course with self-resolution and complete remission over a 4-year follow-up. The literature on primary cutaneous ENKTL has been discussed, with particular attention to clinical and histological prognostic factors.

6.
Photodermatol Photoimmunol Photomed ; 28(3): 169-71, 2012 Jun.
Article in English | MEDLINE | ID: mdl-22548402

ABSTRACT

Psoriasis is a chronic inflammatory skin disease with a high social and psychological impact on the quality of life of patients. Tomesa balneophototherapy is based on bathing in a magnesium-rich salt solution combined with exposure to narrowband ultraviolet B phototherapy. We conducted a retrospective clinical trial on 174 patients affected by mild to severe psoriasis undergoing Tomesa balneophototherapy. The basal course consisted of three to five sessions per week for a total of 30 sessions. Subsequently, patients could continue with a maintenance course of one session per week for a total of 30 sessions. We recorded a significant reduction of the mean Psoriasis Area and Severity Index (PASI) index with an achievement of at least PASI 75 in 52.1% of the 119 patients who completed the basal course and an improvement of the 'quality of life' of patients. The good efficacy obtained by this treatment, and the psychological impact on the quality of life of patients, demonstrated that Tomesa balneophototherapy could be a good option for the treatment of a chronic disease associated with psychological distress, like psoriasis.


Subject(s)
Balneology/methods , Psoriasis/therapy , Ultraviolet Therapy/methods , Adolescent , Adult , Aged , Chronic Disease , Female , Humans , Male , Middle Aged , Psoriasis/pathology , Quality of Life , Retrospective Studies , Severity of Illness Index , Young Adult
7.
Cells ; 10(10)2021 10 17.
Article in English | MEDLINE | ID: mdl-34685762

ABSTRACT

BACKGROUND: Mycosis fungoides (MF) and Sezary Syndrome (SS) are the most common cutaneous T-cell lymphomas. It has been hypothesized that the interaction between the immune system, cutaneous cells, and neoplastic elements may play a role in MF/SS pathogenesis and progression. METHODS: This paper aims to revise in a narrative way our current knowledge of the microenvironment's role in MF/SS. RESULTS AND CONCLUSIONS: Literature data support a possible implication of microenvironment cells in MF/SS pathogenesis and progression, opening up new therapeutic avenues.


Subject(s)
Disease Progression , Mycosis Fungoides/pathology , Mycosis Fungoides/therapy , Sezary Syndrome/pathology , Sezary Syndrome/therapy , Skin Neoplasms/pathology , Skin Neoplasms/therapy , Tumor Microenvironment , Animals , Humans
8.
J Travel Med ; 18(3): 210-1, 2011.
Article in English | MEDLINE | ID: mdl-21539663

ABSTRACT

We present a 31-year-old man who, after a Conus textile sting acquired in New Caledonia, developed a cutaneous abscess on a buttock. The abscess was accompanied by pain, paraesthesia, general malaise, and fever. Complete remission was achieved by sodium hypochlorite packs and oral amoxicillin/clavulanic acid, metronidazole, and tramadol.


Subject(s)
Abscess/etiology , Buttocks , Conotoxins/adverse effects , Skin Diseases, Bacterial/etiology , Abscess/drug therapy , Adult , Animals , Anti-Infective Agents/therapeutic use , Bites and Stings , Buttocks/pathology , Conus Snail , Disinfectants/therapeutic use , Drug Therapy, Combination , Humans , Male , Metronidazole/therapeutic use , New Caledonia , Skin Diseases, Bacterial/drug therapy , Sodium Hypochlorite/therapeutic use
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