ABSTRACT
OBJECTIVE: To investigate the effects of simultaneous cortisol cosecretion (CCS) on body composition in computed tomography (CT)-imaging and metabolic parameters in patients with primary aldosteronism (PA) with the objective of facilitating early detection. DESIGN: Retrospective cohort study. PATIENTS: Forty-seven patients with PA and CCS confirmed by 1-mg dexamethasone suppression test (DST) with a cutoff of ≥1.8 µg/dL were compared with PA patients with excluded CCS (non-CCS, n = 47) matched by age and sex. METHODS: Segmentation of the fat compartments and muscle area at the third lumbar region was performed on non-contrast-enhanced CT images with dedicated segmentation software. Additionally, liver, spleen, pancreas and muscle attenuation were compared between the two groups. RESULTS: Mean cortisol after DST was 1.2 µg/dL (33.1 nmol/L) in the non-CCS group and 3.2 µg/dL (88.3 nmol/L) in the CCS group with mild autonomous cortisol excess (MACE). No difference in total, visceral and subcutaneous fat volumes was observed between the CCS and non-CCS group (p = .7, .6 and .8, respectively). However, a multivariable regression analysis revealed a significant correlation between total serum cholesterol and results of serum cortisol after 1-mg DST (p = .026). Classification of the patients based on visible lesion on CT and PA-lateralization via adrenal venous sampling also did not show any significant differences in body composition. CONCLUSION: MACE in PA patients does not translate into body composition changes on CT-imaging. Therefore, early detection of concurrent CCS in PA is currently only attainable through biochemical tests. Further investigation of the long-term clinical adverse effects of MACE in PA is necessary.
Subject(s)
Hydrocortisone , Hyperaldosteronism , Humans , Retrospective Studies , Body Composition , Tomography, X-Ray Computed/methodsABSTRACT
Objectives: The objective of this research was to describe the prevalence of antibodies to COVID19 in a prison in Ucayali, Peru. Methods: 325 inmates were selected from the Penitentiary Centerin Pucallpa, Peru through simple random sampling. On 06/25/20 and 07/24/20, the fingerpuncture samples were taken from the inmates for COVID-19, the blood sample was obtainedfor the chemo-luminescent microparticle immunoassay tests. Descriptive statistics were usedfor data analysis with InfoStat software. Results: Of the 325 inmates evaluated, 80 were women(25%) and 245 men (75%), the mean age was 43 years (SD 12.44). Regarding the serologicalresults, 137 (42%) were found with positive IgG and 188 (58%) negative IgG. Regarding positiveIgM 145 (45%) and negative IgM 180 (55%). Regarding the distribution of positive cases by sex,we have 47 women and 141 men with a positive result for IgM or IgG. Conclusion: It is concludedthat there is a high number of inmates who have antibodies against COVID-19.
Objetivos: El objetivo de esta investigación fue el de describir la prevalencia de anticuerpos para COVID-19 en una cárcel de Ucayali, Perú. Métodos: Se seleccionaron 325 reclusos del Centro penitenciario en Pucallpa, Perú mediante un muestreo aleatorio simple. Del 25/06/20 y el 24/07/20 se tomaron las muestras punción dactilar de los reclusos para COVID-19, se obtuvo la muestra de sangre para las pruebas de inmunoensayo de micropartículas quimio luminiscentes. Se utilizó estadística descriptiva para en análisis de los datos con el software InfoStat. Resultados: De los 325 reclusos evaluados 80 eran mujeres (25%) y 245 varones (75%), la media de la edad fue de 43 años (DE 12,44). En cuantos a los resultados serológicos se encontraron a con IgG positivo a 137 (42%) e IgG negativo 188 (58%). En cuanto a IgM positivo 145 (45%) e IgM negativo 180 (55%). En cuanto a la distribución de casos positivos por sexo contamos con 47 mujeres y 141 varones con resultado positivo para IgM o IgG. Conclusión: Se concluye con que existe un elevado número de reclusos que tienen anticuerpos contra la COVID-19.