Neurocomputational mechanisms of young children's observational learning of delayed gratification.

The ability to delay gratification is crucial for a successful and healthy life. An effective way for young children to learn this ability is to observe the action of adult models. However, the underlying neurocomputational mechanism remains unknown. Here, we tested the hypotheses that children employed either the simple imitation strategy or the goal-inference strategy when learning from adult models in a high-uncertainty context. Results of computational modeling indicated that children used the goal-inference strategy regardless of whether the adult model was their mother or a stranger. At the neural level, results showed that successful learning of delayed gratification was associated with enhanced interpersonal neural synchronization (INS) between children and the adult models in the dorsal lateral prefrontal cortex but was not associated with children's own single-brain activity. Moreover, the discounting of future reward's value obtained from computational modeling of the goal-inference strategy was positively correlated with the strength of INS. These findings from our exploratory study suggest that, even for 3-year-olds, the goal-inference strategy is used to learn delayed gratification from adult models, and the learning strategy is associated with neural interaction between the brains of children and adult models.

Lattice Mismatch-Induced Formation of Copper Nanoplates with Embedded Ultrasmall Platinum or Palladium Cores for Tunable Optical Properties.

Although noble metal nanocrystals have been studied extensively in the past decades, the shape-controlled synthesis of non-noble metal nanocrystals has remained challenging with limited success, which is a grand obstacle to their wide applications. Herein, a novel lattice mismatch-involved shape-control mechanism of Cu nanocrystals in a seed-mediated synthesis is reported, which can produce Cu nanoplates in high yield with tailored sizes (28-130 nm), holding great potential in optical and catalytic applications. The lattice mismatch between Cu and the seed is found effective in inducing crystallographic defects for symmetry breaking toward anisotropic nanocrystals. While a too-large lattice mismatch (11.7% for Au seeds) leads to multiple twin defects to form quasi-spherical Cu nanocrystals, an appropriately large lattice mismatch (7.7% for Pt and 6.9% for Pd seeds) successfully induces planar defects for the formation of Cu nanoplates. The size of the Cu nanoplates is customizable by controlling the concentration of the seeds, leading to tunable optical properties. A prototype of a colorimetric indicator with Cu nanoplates, potentially applicable to the safety control of foods and drugs is demonstrated. This mechanism paves a new way for the shape-controlled synthesis of Cu and other metal nanocrystals for a broad range of applications.

Involvement of Methoprene-tolerant and Krüppel homolog 1 in juvenile hormone-mediated vitellogenesis of female Liposcelis entomophila (End.) (Psocoptera: Liposcelididae).

Methoprene-tolerant (Met) as an intracellular receptor of juvenile hormone (JH) and the Krüppel-homolog 1 (Kr-h1) as a JH-inducible transcription factor had been proved to contribute to insect reproduction. Their functions vary in different insect orders, however, they are not clear in Psocoptera. In this study, LeMet and LeKr-h1 were identified and their roles in vitellogenesis and ovarian development were investigated in Liposcelis entomophila (Enderlein). Treatment with exogenous JH III significantly induced the expression of LeKr-h1, LeVg, and LeVgR. Furthermore, silencing LeMet and LeKr-h1 remarkably reduced the transcription of LeVg and LeVgR, disrupted the production of Vg in fat body and the uptake of Vg by oocytes, and ultimately led to a decline in fecundity. The results indicated that the JH signaling pathway was essential to the reproductive process of this species. Interestingly, knockdown of LeMet or LeKr-h1 also resulted in fluctuations in the expression of FoxO, indicating the complex regulatory interactions between different hormone factors. Besides, knockdown of both LeMet and LeKr-h1 significantly increased L. entomophila mortality. Our study provides initial insight into the roles of JH signaling in the female reproduction of psocids and provided evidence that RNAi-mediated knockdown of Met or Kr-h1 is a potential pest control strategy.

Effects of blood pressure and antihypertensive drugs on osteoarthritis: a mendelian randomized study.

BACKGROUND: Previous studies have suggested that antihypertensive drugs may play a role in the treatment of osteoarthritis, but these studies may be limited by confounding factors and lead to biased results. Therefore, we conducted a Mendelian randomization study to investigate the effects of blood pressure and antihypertensive drugs on osteoarthritis. METHODS: We used published large-scale genome-wide association data and applied univariate and multivariate Mendelian randomization methods. The main analysis model was inverse variance weighting, and the reliability of the results was tested using MR-Egger intercept analysis, Cochran's Q test, and leave-one-out analysis. We comprehensively evaluated the relationship between systolic blood pressure, diastolic blood pressure, 12 antihypertensive drugs, and osteoarthritis. We also conducted verification in the independent queue of UK Biobank and built a simple linear regression model to obtain an independent comparison. RESULTS: We found no evidence that systolic and diastolic blood pressure significantly affected osteoarthritis. However, among antihypertensive drugs, we observed a significant positive correlation between potassium-preserving diuretics and aldosterone antagonists and all osteoarthritis (OR: 0.560, 95% CI 0.406-0.772, P = 0.0004). Sensitivity analysis showed no horizontal pleiotropy or heterogeneity, and the leave-one-out analysis demonstrated the reliability of the results. This result was replicated with nominally statistical significance in the validation cohort and exhibited significant correlation in the linear regression analysis. CONCLUSIONS: Our study suggested that controlling the protein targets of potassium-sparing diuretics and aldosterone antagonists may have beneficial results for osteoarthritis. These findings provide valuable medication strategies for the control of hypertension in patients with osteoarthritis.

How Mother-Child Interactions are Associated with a Child's Compliance.

While social interaction between a mother and her child has been found to play an important role in the child's committed compliance, the underlying neurocognitive process remains unclear. To investigate this process, we simultaneously recorded and assessed brain activity in 7-year-old children and in children's mothers or strangers during a free-play task using functional near-infrared spectroscopy-based hyperscanning. The results showed that a child's committed compliance was positively associated with the child's responsiveness but was negatively associated with mutual responsiveness and was not associated with the mother's responsiveness during mother-child interactions. Moreover, interpersonal neural synchronization (INS) at the temporoparietal junction mediated the relationship between the child's responsiveness and the child's committed compliance during mother-child interactions when the child's brain activity lagged behind that of the mother. However, these effects were not found during stranger-child interactions, nor were there significant effects in the mother-child pair when no real interactions occurred. Finally, we found a transfer effect of a child's committed compliance from mother-child interactions to stranger-child interactions via the mediation of mother-child INS, but the opposite did not occur. Together, these findings suggest that a child's responsiveness during mother-child interactions can significantly facilitate her or his committed compliance by increasing mother-child INS.

Attachment goes to court: child protection and custody issues.

Attachment theory and research are drawn upon in many applied settings, including family courts, but misunderstandings are widespread and sometimes result in misapplications. The aim of this consensus statement is, therefore, to enhance understanding, counter misinformation, and steer family-court utilisation of attachment theory in a supportive, evidence-based direction, especially with regard to child protection and child custody decision-making. The article is divided into two parts. In the first, we address problems related to the use of attachment theory and research in family courts, and discuss reasons for these problems. To this end, we examine family court applications of attachment theory in the current context of the best-interest-of-the-child standard, discuss misunderstandings regarding attachment theory, and identify factors that have hindered accurate implementation. In the second part, we provide recommendations for the application of attachment theory and research. To this end, we set out three attachment principles: the child's need for familiar, non-abusive caregivers; the value of continuity of good-enough care; and the benefits of networks of attachment relationships. We also discuss the suitability of assessments of attachment quality and caregiving behaviour to inform family court decision-making. We conclude that assessments of caregiver behaviour should take center stage. Although there is dissensus among us regarding the use of assessments of attachment quality to inform child custody and child-protection decisions, such assessments are currently most suitable for targeting and directing supportive interventions. Finally, we provide directions to guide future interdisciplinary research collaboration.

Vertical stability of different orthognathic treatments for correcting skeletal anterior open bite: a systematic review and meta-analysis.

BACKGROUND: Several orthognathic procedures have been applied to correct skeletal anterior open bites (SAOB). Which method is most stable has been debated and no consensus has been reached and there is no conclusive evidence for clinicians to use. OBJECTIVE: To analyse whether maxillary, mandibular, or bimaxillary surgery provides a better stability. MATERIALS AND METHODS: A systematic search was conducted up to December 2020 using PubMed, EMBASE, Medline, Scopus, Web of Science, Cochrane CENTRAL, and Google Scholar. We made direct comparisons among the controlled trials and also made indirect comparisons via subgroup analysis on the aspects of occlusional, skeletal, and dento-alveolar stability to assess the overall stability of each method. RESULTS: Finally 16 cohort studies were identified. At the occlusional level, pooled change in overbite was 0.21 mm in maxillary surgery, 0.37 mm in bimaxillary surgery, and -0.32 mm in mandibular surgery. At the skeletal level, pooled sella-nasion-Point A angle (SNA) was -0.12 degrees in bimaxillary surgery, -0.37 degrees in maxillary surgery and -0.20 degrees in mandibular surgery. The sella-nasion to palatal plane angle (SNPP) relapsed to a statistically significant degree in all samples received single maxillary surgery. Relapse of the sella-nasion-Point B angle (SNB) was 0.47 degrees in mandibular setback, -1.8 degrees in mandibular advancement, and -0.48 degrees in maxillary surgery. The Sella-Nasion to mandibular plane angle (SNMP) relapsed more in procedures involving bilateral sagittal split osteotomy than in other procedures. As for dento-alveolar changes, intrusion of molars and extrusion of incisors took place in most patients. CONCLUSIONS: Bimaxillary surgery produced the most beneficial post-operative increase in overbite, maxillary surgery led to a lesser but still positive overbite change, and mandibular surgery correlated with some extent of relapse. Skeletally, bimaxillary surgery was more stable than maxillary surgery at both SNA and SNPP; SNB was more stable in mandibular setback than advancement; and SNMP was unstable in both mandibular and bimaxillary surgeries versus maxillary surgery with comparable surgical changes. Dento-alveolar compensation helped maintain a positive overbite. REGISTRATION NUMBER: CRD42020198088.

Synthesis and surface modification of mesoporous metal-organic framework (UiO-66) for efficient pH-responsive drug delivery and lung cancer treatment.

This paper applied mesoporous metal-organic frameworks (MOFs) of UiO-66 particles for pH-responsive doxorubicin (DOX) delivery and cancer treatment. Mesoporous structured UiO-66 MOFs were synthesized, and carboxymethylcellulose (CMC) was loaded for sensitive pH response and also as a linker to encapsulate the chemotherapeutic drug of DOX. The composite of UiO-66/CMC@DOX was synthesized, and the loading capacity was as high as 45µg DOX per mg of the carrier. The structure and crystalization of the UiO-66 MOFs were determined by the Transmitting Electron Microscope (TEM) and x-ray diffraction methods, while the loading of CMC and DOX was inspected by Fourier Transform InfraRed (FT-IR) and UV-vis spectroscopy. The DOX release from UiO-66/CMC@DOX was tested under different pH at 37 °C. The DOX accumulative release could reach 78% under the pH of 5. A lower pH was more favorable for DOX release due to the CMC shrinking and higher DOX solubility in an acidic environment. The cytotoxicity study indicated that, under the DOX concentration of 4µg ml-1, the A549 cell (Lung Carcinoma Cell Line) viability of UiO-66/CMC was 28%, which was lower than that from free DOX solution (47%). UiO-66 MOFs were demonstrated to be an efficient drug delivery carrier for chemotherapeutic drug and release.

Behavioral Inhibition in Early Childhood and Adjustment in Late Adolescence in China.

This study examined relations between behavioral inhibition in toddlerhood and social, school, and psychological adjustment in late adolescence in China. Data on behavioral inhibition were collected from a sample of 2-year-olds (initial N = 247). Follow-up data were collected at 7 years for peer relationships and 19 years for adjustment across domains. The results showed that early inhibition positively predicted later social competence and school adjustment. Peer relationships in middle childhood served as a protective factor in the development of depression of inhibited children. The results indicate the distinct functional meaning of behavioral inhibition in the Chinese context from a developmental perspective.

Cool and hot effortful control moderate how parenting predicts child internalization in Chinese families.

Internalization of external rules is a behavioral manifestation of moral development during childhood, and its development has come to be understood from the view of a complex parenting-by-temperament process. To examine this developmental process, the current research investigated how maternal parenting behaviors and child effortful control foretell internalization throughout early to middle childhood with two longitudinal samples of Chinese mother-child dyads. In Study 1 (N = 226), maternal respect for autonomy and negative control during free plays at 15 months of age were observed. At 25 months, child cool and hot effortful control were measured with a Stroop-like categorization task and an externally imposed delay task. At 37 months, observed internalization of maternal rules was assessed. Results showed that for toddlers with high levels of cool effortful control, maternal respect for autonomy positively predicted later internalization. In Study 2 (N = 88), maternal respect for autonomy and negative control during free plays at 38 months of age were coded. At 60 months, child cool and hot effortful control were measured with a Stroop-like inhibition task and a delay-of-gratification task. Observed internalization of maternal and experimenter rules and mother-reported internalization in everyday life were assessed at 60 and 84 months. Results showed that for children low on either cool or hot effortful control, maternal respect for autonomy negatively predicted later internalization during childhood. Together, the current findings support an age-relevant goodness-of-fit model for internalization development in Chinese children throughout the first 7 years of life.

Identification and genetic analysis of alternative splicing of long non-coding RNAs in tomato initial flowering stage.

Alternative splicing (AS) is a key modulator of development in many eukaryotic organisms. Long non-coding RNAs (lncRNAs) are a class of non-coding RNAs that play essential regulatory roles in various developmental processes and stress responses. However, the functions of AS lncRNAs during the initial flowering of tomato are largely unknown. This study was designed to investigate the AS pattern of lncRNAs in tomato flower, leaf, and root tissues at the initial flowering stage. Using RNA-Seq, we found that 72.55% of lncRNAs underwent AS in these tissues, yielding a total of 16,995 AS events. Among them, the main type of AS event is alternative first exon (AFE), followed by retained intron (RI). We performed candidate target genes analysis on tissue-specific AS lncRNA, and the results indicated that the candidate target genes of these lncRNAs may be involved in the regulation of circadian rhythm, plant immunity, cellulose synthesis and phosphate-containing compound metabolic process. Moreover, a total of 73,085 putative SNPs and 15,679 InDels were detected, and the potential relationship between the AS of lncRNAs and interesting SNP and InDel loci, as well as their numbers, revealed their effects on tomato genetic diversity and genomic stability. Our data provide new insights into the complexity of the transcriptome and the regulation of AS.

Grandmothers are part of the parenting network, too! A longitudinal study on coparenting, maternal sensitivity, child attachment and behavior problems in a Chinese sample.

Grandmothers are important in Chinese families. This study explored the early emerging mother-grandmother-infant network and its association with child's socioemotional development in multigenerational families in a non-WEIRD country. The analytic sample included 60 children (T1: Mage  = 6.5 months) and their caregivers residing in Beijing. Measures used were the Strange Situation Procedure (SSP), the Lausanne Trilogue Play (LTP), the Maternal Behavior Q-Sort (MBQS), and the Infant-Toddler Social and Emotional Assessment. Structural equation and path modeling revealed that (1) more grandmaternal neutral/watching coparenting behaviors at the first assessment were related to more secure infant-mother attachment relationships at the second assessment (T2: Mage  = 1 year); (2) maternal sensitivity at T2 was a partial mediator between earlier undermining and neutral/watching coparenting behaviors and young children's externalizing problems at the final assessment (T3: Mage  = 2 years). Findings are discussed in terms of the roles played by mother-grandmother coparenting network in the children's socioemotional development.

Polymorphisms of pfcrt, pfmdr1, and K13-propeller genes in imported falciparum malaria isolates from Africa in Guizhou province, China.

BACKGROUND: Imported falciparum malaria from Africa has become a key public health challenge in Guizhou Province since 2012. Understanding the polymorphisms of molecular markers of drug resistance can guide selection of antimalarial drugs for the treatment of malaria. This study was aimed to analyze the polymorphisms of pfcrt, pfmdr1, and K13-propeller among imported falciparum malaria cases in Guizhou Province, China. METHOD: Fifty-five imported falciparum malaria cases in Guizhou Province during 2012-2016 were included in this study. Their demographic information and filter paper blood samples were collected. Genomic DNA of Plasmodium falciparum was extracted from the blood samples, and polymorphisms of pfcrt, pfmdr1, and K13-propeller were analyzed with nested PCR amplification followed by sequencing. Data were analyzed with the SPSS17.0 software. RESULTS: The prevalence of pfcrt K76T, pfmdr1 N86Y, and pfmdr1 Y184F mutation was 56.6, 22.2, and 72.2%, respectively, in imported falciparum malaria cases in Guizhou Province. We detected two mutant haplotypes of pfcrt, IET and MNT, with IET being more commonly found (54.7%), and five mutant haplotypes of pfmdr1, of which NFD was the most frequent (53.7%). There were totally 10 combined haplotypes of pfcrt and pfmdr1, of which the haplotype IETNFD possessed a predominance of 28.8%. In addition, three nonsynonymous mutations (S459T, C469F, and V692L) and two synonymous mutations (R471R and V589V) were detected in K13-propeller, all having prevalence less than 6.0%. In particular, a candidate K13 resistance mutation, C469F, was identified for the first time from Democratic Republic of the Congo with the prevalence of 2.0%. CONCLUSIONS: The high prevalence of IET haplotype of pfcrt and NFD haplotype of pfmdr1 suggests the presence of chloroquine, artemether/lumefantrine, and dihydroartemisinin/piperaquine resistance in these cases. Therefore cautions should be made to artemisinin therapy for P. falciparum in Africa. Continuous monitoring of anti-malarial drug efficacy in imported malaria cases is helpful for optimizing antimalarial drug therapy in Guizhou Province, China.

Infant withdrawal and behavior problems in urban Chinese toddlers: Roles of maternal sensitivity to infant distress and emerging delay ability.

Using a longitudinal design, this study examined the associations between infant temperamental withdrawal and behavior problems during toddlerhood and tested the moderating effects of maternal sensitivity to infant distress (MSID) and toddlers' ability to delay gratification (ADG) in urban Chinese families. Participants were 84 Chinese children (37 boys, 47 girls) and their mothers. When the infants were 6 months old (T1: infancy), their mothers reported their temperamental withdrawal, and research assistants observed and coded MSID by using a subscale of the Maternal Behavior Q-Sort during free-play interaction. When the toddlers were 1 year old (T2: early toddlerhood), their mothers reported their internalizing and externalizing problems. When the toddlers were 2 years old (T3: late toddlerhood), their mothers again reported their internalizing and externalizing problems, and their abilities of delay gratification were assessed through a laboratory-based procedure. Infant temperamental withdrawal was associated with increased internalizing problems in early toddlerhood and increased externalizing problems during middle to late toddlerhood; infants whose mothers were extremely high sensitive or low sensitive to their distress or those with late poor ability of delay gratification were at particular risk. The findings highlight the importance of matching parenting and promotion of self-control for temperamental withdrawn children's optimal development.

Usando un diseño longitudinal, este estudio examinó las asociaciones entre el despego temperamental del infante y los problemas de comportamiento durante la primera infancia y sometió a prueba los efectos de moderación de la sensibilidad materna en la angustia del infante (MSID) y la habilidad de los niños pequeñitos de retrasar la gratificación (ADG) en familias urbanas chinas. Los participantes finales fueron 84 niños chinos (con 37 varones y 47 niñas) y sus madres. Cuando los infantes tenían seis meses de edad (T1: infancia), sus madres reportaron su despego temperamental, y los asistentes de investigación observaron y codificaron la sensibilidad materna a la angustia del infante usando una sub-escala Q-Sort de Conducta Materna durante la interacción de juego libre. Cuando los niños pequeñitos tenían un año de edad (T2: la primera parte de la temprana niñez), sus madres reportaron los problemas de internalización y externalización de los niños. Cuando los niños tenían dos años de edad (T3: la última etapa de la temprana niñez), sus madres reportaron otra vez los problemas de internalización y externalización de los niños, y sus habilidades para retrasar la gratificación fueron evaluadas por medio de un procedimiento con base en el laboratorio. Se asoció el despego temperamental del infante con un aumento de problemas de internalización en la primera parte de la temprana niñez y con un aumento de problemas de externalización durante la segunda mitad de la temprana niñez; los infantes cuyas madres eran en extremo alta o bajamente sensitivas a la angustia de los infantes o aquellos con una tardía pobre habilidad de retrasar la gratificación se encontraban bajo riesgo particular. Los resultados resaltan la importancia de enlazar la crianza y la promoción del autocontrol para el desarrollo óptimo del despego temperamental de los niños.

Utilisant une conception longitudinale, cette étude a examiné les associations entre le retrait tempéramental du nourrisson et les problèmes de comportement durant la petite enfance, et a testé les effets de modération de la sensibilité maternelle à la détresse du nourrisson (abrégé ici en français MSDN) et de la capacité des petits enfants à retarder la gratification (abrégé ici CRG) chez des familles chinoises urbaines. Les participants à l'étude ont consisté en 84 enfants chinois (37 garçons et 47 filles) et leurs mères. Lorsque les nourrissons ont atteint l'âge de six mois (T1 : bas âge), leurs mères ont fait état de leur tempérament de retrait, et les assistants de recherche ont observé et codé la sensibilité maternelle à la détresse du bébé en utilisant un sous-échelle de Q-sorts de comportements maternels durant une interaction de jeu libre. Lorsque les bébés ont atteint l'âge de un an (T2 : début de la petite enfance), leurs mères ont fait état de leurs problèmes d'internalisation et d'externalisation. Lorsque les enfants ont atteint l'âge de deux ans (T3 : fin de la petite enfance) leurs mères ont à nouveau fait état de leurs problèmes d'internalisation et d'externalisation et leurs capacités à retarder la gratification ont été évaluées à travers une procédure en laboratoire. Le retrait tempéramental du nourrisson était lié à des problèmes d'internalisation importants dans la très petite enfance et des problèmes d'externalisation importants durant le milieu et la fin de la petite enfance. Les bébés dont les mères étaient extrêmement sensibles ou peu sensibles à leur détresse ou ceux ayant une faible et tardive capacité de retard de la gratification étaient à risque particulier. Les résultats mettent en lumière l'importance qu'il y a à faire correspondre le parentage et la promotion du contrôle de soi pour le développement optimal des enfants ayant un retrait comportemental.

Response and outcome from fluid resuscitation in acute pancreatitis: a prospective cohort study.

BACKGROUND: Intravenous (IV) fluid resuscitation remains the cornerstone for early management of acute pancreatitis (AP), but many questions remain unanswered, including how to determine whether patients will benefit from additional fluids. The aim was to investigate the utility of serum biomarkers of responsiveness IV fluid resuscitation in patients with AP and systemic inflammatory response syndrome (SIRS). METHODS: Eligible adult patients had abdominal pain for <36 h and ≥2 SIRS criteria. Mean arterial pressure (>65 mmHg) and urine output (>0.5 ml/kg/h) were used to assess responsiveness at 2 and 6-8 h after initiation of IV fluids. Comparison was made between responsive and refractory patients at time points for fluid volume, biomarkers and outcomes. RESULTS: At 2 h 19 patients responded to fluids (Group 1) while 4 were refractory (Group 2); at 6-8 h 14 responded (Group 3) and 9 were refractory (Group 4). No demographic differences between patient groups, but Group 4 had worse prognostic features than Group 3. Refractory patients received significantly more fluid (Group 4 mean 7082 ml vs. Group 3 5022 mL, P < 0.001) in first 24 h and had worse outcome. No significant differences in biomarkers between the groups. CONCLUSIONS: The serum biomarkers did not discriminate between fluid responsive and refractory patients. Refractory patients at 6-8 h had more severe disease on admission, did not benefit from additional fluids and had a worse outcome. New approaches to guide fluid resuscitation in patients with AP are required.

Host Volatiles Potentially Drive Two Evolutionarily Related Weevils to Select Different Grains.

The Sitophilus zeamais (maize weevil) and Sitophilus oryzae (rice weevil) are two insect pests that have caused huge economic losses to stored grains worldwide. It is urgent to develop an environmentally friendly strategy for the control of these destructive pests. Here, the olfactory-mediated selection preference of the two weevil species to three stored grains was analyzed, which should help establish a pull-push system in managing them. Bioassays showed that maize weevil adults prefer to select maize, followed by paddy and wheat, while rice weevil adults mainly migrate towards wheat. Volatile analyses revealed that 2-ethylhexanol, piperitone, and (+)-Δ-cadiene are the major components in volatiles from both maize and wheat, but the abundance of these chemicals is much lower in maize than that in wheat. The volatile limonene was only detected in paddy. Y-tube bioassays suggest that 2-ethylhexanol, piperitone, and (+)-Δ-cadiene were all attractive to both weevils, whereas limonene was attractive only to rice weevils. Overall, maize weevil appeared more sensitive to the tested volatiles based on having much lower effective concentrations of these volatiles needed to attract them. The differences in volatile profiles among the grains and the sensitivity of the two species towards these volatiles may explain the behavioral differences between maize and rice weevils in selecting host grains. The differences in sensitivity of maize and rice weevils towards host volatile components with abundance differences are likely determinants driving the two insect species to migrate towards different host grains.

Infants' cortisol reactivity and infant-mother cortisol synchrony in urban Chinese families: The role of maternal control strategy.

Maternal control strategy refers to a mother's practices used to impel, inhibit, guide, or shape their children's behaviors during mother-child interaction. The present study examined control strategies used by Chinese urban mothers and how they associated with infants' cortisol trajectory and infant-mother cortisol synchrony during a separation task. Participants were 115 infant-mother dyads. Maternal control strategy was assessed during mother-infant free-play when the infants were 6 months (T1) and 1 year (T2) old. Salivary cortisol samples were collected from both infants and mothers during a stress-inducing task at T2. The results indicated that mothers most frequently adopted the moderate power control strategy, at both T1 and T2. T1 maternal low control strategy significantly predicted infants' cortisol response curve, namely infants of mothers who predominantly adopted a low power control strategy had a more dynamic reactivity and recovery in their cortisol response to the separation task. Positive cortisol synchrony was observed between mothers and infants during the separation stress condition. In addition, T2 maternal high power control strategy accounted for inter-individual variations in infant-mother cortisol synchrony, such that mothers who predominantly adopted a high power control strategy exhibited a heightened level of cortisol synchrony with their infants. Our findings suggest that targeted training in maternal control strategies could help mothers calibrate their infants' adrenocortical regulation.

A Soft Inductive Bimodal Sensor for Proprioception and Tactile Sensing of Soft Machines.

The somatosensory system is crucial for living beings to survive and thrive in complex environments and to interact with their surroundings. Similarly, rapidly developed soft robots need to be aware of their own posture and detect external stimuli. Bending and force sensing are key for soft machines to achieve embodied intelligence. Here, we present a soft inductive bimodal sensor (SIBS) that uses the strain modulation of magnetic permeability and the eddy-current effect for simultaneous bidirectional bending and force sensing with only two wires. The SIBS is made of a flexible planar coil, a porous ferrite film, and a soft conductive film. By measuring the inductance at two different frequencies, the bending angle and force can be obtained and decoupled. Rigorous experiments revealed that the SIBS can achieve high resolution (0.44° bending and 1.09 mN force), rapid response, excellent repeatability, and high durability. A soft crawling robot embedded with one SIBS can sense its own shape and interact with and respond to external stimuli. Moreover, the SIBS is demonstrated as a wearable human-machine interaction to control a crawling robot via wrist bending and touching. This highlights that the SIBS can be readily implemented in diverse applications for reliable bimodal sensing.

Revealing the impact of autophagy-related genes in rheumatoid arthritis: Insights from bioinformatics.

Background: Rheumatoid arthritis is a systemic inflammatory autoimmune disease that severely impacts physical and mental health. Autophagy is a cellular process involving the degradation of cellular components in lysosomes. However, from a bioinformatics perspective, autophagy-related genes have not been comprehensively elucidated in rheumatoid arthritis. Methods: In this study, we performed differential analysis of autophagy-related genes in rheumatoid arthritis patients using the GSE93272 dataset from the Gene Expression Omnibus database. Marker genes were screened by least absolute shrinkage and selection operator. Based on marker genes, we used unsupervised cluster analysis to elaborate different autophagy clusters, and further identified modules strongly associated with rheumatoid arthritis by weighted gene co-expression network analysis. In addition, we constructed four machine learning models, random forest model, support vector machine model, generalized linear model and extreme gradient boosting based on marker genes, and based on the optimal machine learning model, a nomogram model was constructed for distinguishing between normal individuals and rheumatoid arthritis patients. Finally, five external independent rheumatoid arthritis datasets were used for the validation of our results. Results: The results showed that autophagy-related genes had significant expression differences between normal individuals and osteoarthritis patients. Through least absolute shrinkage and selection operator screening, we identified 31 marker genes and found that they exhibited significant synergistic or antagonistic effects in rheumatoid arthritis, and immune cell infiltration analysis revealed significant changes in immune cell abundance. Subsequently, we elaborated different autophagy clusters (cluster 1 and cluster 2) using unsupervised cluster analysis. Next, further by weighted gene co-expression network analysis, we identified a brown module strongly associated with rheumatoid arthritis. In addition, we constructed a nomogram model for five marker genes (CDKN2A, TP53, ATG16L2, FKBP1A, and GABARAPL1) based on a generalized linear model (area under the curve = 1.000), and the predictive efficiency and accuracy of this nomogram model were demonstrated in the calibration curves, the decision curves and the five external independent datasets were validated. Conclusion: This study identified marker autophagy-related genes in rheumatoid arthritis and analyzed their impact on the disease, providing new perspectives for understanding the role of autophagy-related genes in rheumatoid arthritis and providing new directions for its individualized treatment.