Correlation of Sedation Depth During Critical Care Transport and Hospitalization.

Purpose: We aim to assess the impact of the exposure to deep versus light sedation by a critical care transport agency during prehospital and interhospital transport on hospital sedation levels, medication exposure, and outcomes of mechanically ventilated patients. Materials and Methods: Retrospective cohort review of mechanically ventilated adult critical care transport patients from January 1, 2019, to March 11, 2020, who arrived at an academic medical center. The primary outcome was the correlation of deep sedation during transport with deep sedation within the first 48 h of hospitalization (defined as Richmond Agitation Sedation Scale [RASS] -3 to -5). The secondary outcomes were duration of mechanical ventilation, hospital length of stay, intensive care unit (ICU) length of stay, inpatient mortality, delirium within 48 h, and coma within 48 h. Results: One hundred and ninety-eight patients were included, of whom 183 (92.4%) were deeply sedated during transport which persisted through the first 48 h of hospital care. Deep sedation during transport was not correlated with deep sedation in the hospital within the first 48 h (OR 2.41; 95% CI, 0.48-12.02). There was no correlation with hospital length of stay, ICU length of stay, duration of mechanical ventilation, or hospital mortality. Deep sedation during transport was not correlated with delirium or coma within the first 48 h of hospitalization. There was a negligible correlation between final transport RASS and initial hospital RASS which did not differ based on the lapsed time from handoff (<1 h corr. coeff. 0.23; ≥1 h corr. coeff. 0.25). Conclusions: Deep sedation was observed during critical care transport in this cohort and was not correlated with deep sedation during the first 48 h of hospitalization. The transition of care between the transport team and the hospital team may be an opportunity to disrupt therapeutic momentum and re-evaluate sedation decisions.

Sedation Practices of Mechanically Ventilated Patients During Critical Care Transport.

OBJECTIVE: Mechanically ventilated patients who receive deep levels of sedation have high mortality rates, longer lengths of stay, and longer duration of mechanical ventilation in the intensive care unit. Prior literature demonstrated a high frequency of deep sedation across all levels of care. Benzodiazepines have been attributed to similar morbidity and mortality findings. METHODS: This study was a descriptive retrospective review of mechanically ventilated adult critical care transport patients from January 1, 2019, to March 11, 2020. Our primary outcome was the percentage of patients who were deeply sedated at handoff to the receiving facility. Deep sedation was defined as a Richmond Agitation Sedation Scale of -3 to -5. Our secondary outcomes were the percentage of patients who received benzodiazepines; the number of unplanned extubations, crew injuries, and unsafe patient care situations; and the incidence of ventilator dyssynchrony. RESULTS: Five hundred fifty-three mechanically ventilated patients were transported. Ninety-three patients were excluded because they received paralytics during transport. Four hundred sixty patients were included in the analysis, 422 (91.7%) of whom were deeply sedated. Benzodiazepines were administered to 141 patients (30.6%). There were no differences observed in the secondary outcomes. CONCLUSION: Deep sedation and benzodiazepine administration were frequent during critical care transport of mechanically ventilated patients.

Prevalence of arterial branches arising from the extracranial internal carotid artery on CT angiography.

Although it is well known that arterial branches may rarely arise from the cervical internal carotid artery (ICA), their incidence has not been adequately evaluated on computed tomography angiography (CTA). We investigate the prevalence of congenital and non-congenital anomalous branches arising from the cervical ICA by a 5 year retrospective review of neck CTAs performed on 2,602 patients. We found a higher frequency of arteries arising from the ICA than suggested by the existing literature, including a 0.49 % prevalence of the occipital artery origin and a 6.25 % prevalence of the superior pharyngeal branch of (the pharyngeal trunk of) the ascending pharyngeal artery. In addition, six cases of recanalized intersegmental arteries providing collateral flow to the cervical ICA from the cervical vertebral artery were identified. This is the first large, retrospective CTA study evaluating the incidence of these anomalous vessel origins.

Improving the Corrosion Performance of Organically Coated Steel Using a Sol-Gel Overcoat.

Organically coated steels are widely used in applications in which they are subjected to the natural environment and therefore require excellent corrosion resistance. Organic clearcoats are typically employed as a barrier that improves the overall corrosion resistance; however, they are typically derived from fossil fuel-based feedstock. A more sustainable alternative could be possible using sol-gel coatings. The application of a simple tetraethoxysilane (TEOS)-based sol-gel was applied to polyurethane-coated steels using a spray coater. The concentration of TEOS was altered to produce coatings containing either 2.5% or 10%. The 10% TEOS resulted in dense, homogeneous coatings that offered a significant improvement in corrosion resistance compared to an uncoated substrate. Whereas the 2.5% TEOS coatings were inhomogeneous and porous, which indicated a limitation of concentration required to produce a uniform coating. The successful demonstration of using a simple TEOS-based coating to improve the corrosion resistance of organically coated steel highlights the potential for further investigation into the use of sol-gels for these applications.

Single cell analysis of cribriform prostate cancer reveals cell intrinsic and tumor microenvironmental pathways of aggressive disease.

Cribriform prostate cancer, found in both invasive cribriform carcinoma (ICC) and intraductal carcinoma (IDC), is an aggressive histological subtype that is associated with progression to lethal disease. To delineate the molecular and cellular underpinnings of ICC/IDC aggressiveness, this study examines paired ICC/IDC and benign prostate surgical samples by single-cell RNA-sequencing, TCR sequencing, and histology. ICC/IDC cancer cells express genes associated with metastasis and targets with potential for therapeutic intervention. Pathway analyses and ligand/receptor status model cellular interactions among ICC/IDC and the tumor microenvironment (TME) including JAG1/NOTCH. The ICC/IDC TME is hallmarked by increased angiogenesis and immunosuppressive fibroblasts (CTHRC1+ASPN+FAP+ENG+) along with fewer T cells, elevated T cell dysfunction, and increased C1QB+TREM2+APOE+-M2 macrophages. These findings support that cancer cell intrinsic pathways and a complex immunosuppressive TME contribute to the aggressive phenotype of ICC/IDC. These data highlight potential therapeutic opportunities to restore immune signaling in patients with ICC/IDC that may afford better outcomes.