Seeding fiber amplifiers with piecewise parabolic phase modulation for high SBS thresholds and compact spectra.

We propose using piecewise parabolic phase modulation of the seed laser for suppressing stimulated Brillouin scattering (SBS) in a fiber amplifier. Simulations are run with a 9 m passive fiber. Compared with random phase modulation and 0-π pseudo-random phase modulation, the piecewise parabolic phase waveform yields a higher SBS threshold per unit bandwidth. If the bandwidth is defined as the range of frequencies containing 85% of the total power, the threshold for parabolic phase modulation is 1.4 times higher than the threshold for the five- or seven-bit pseudo-random modulation format. If the bandwidth is defined more tightly, e.g., the range of frequencies containing 95% of the total power, the threshold for parabolic phase modulation is three times higher. For both cases, achieving a bandwidth of 1.5 GHz requires a maximum phase shift of ~30 radians. All of the waveforms are compared on the basis of the bandwidth required of the phase moduator. The coherence functions are calculated in order to compare their suitability for coherent combining.

Polarization-filtering and polarization-maintaining low-loss negative curvature fibers.

We propose a polarization-filtering and polarization-maintaining negative curvature fiber in which two nested resonant tubes are added to a standard negative curvature fiber with one ring of tubes. The coupling between the glass modes in the nested resonant tubes and the fundamental core modes is used to increase the birefringence and differential loss for the fundamental core modes in the two polarizations. We show computationally that the birefringence and the loss ratio between the modes in the two polarizations can reach 10-5 and 850, respectively. Meanwhile, the low-loss mode has a loss that is lower than 0.02 dB/m. The relatively simple design of this polarization-maintaining negative curvature fiber will be useful in hollow-core fiber devices that are sensitive to polarization effects, such as fiber lasers, fiber interferometers, and fiber sensors.

Bending-induced mode non-degeneracy and coupling in chalcogenide negative curvature fibers.

We study bend loss in chalcogenide negative curvature fibers with different polarizations, different tube wall thicknesses, and different bend directions relative to the mode polarization. The coupling between the core mode and tube modes induces bend loss peaks in the two non-degenerate modes at the same bend radius. There is as much as a factor of 28 difference between the losses of the two polarization modes. The fiber with a larger tube wall thickness, corresponding to a smaller inner tube diameter, can sustain a smaller bend radius. The bend loss is sensitive to the bend direction when coupling occurs between the core mode and tube modes. A bend loss of 0.2 dB/m at a bend radius of 16 cm, corresponding to 0.2 dB/turn, can be achieved in a chalcogenide negative curvature fiber.

Higher-order mode suppression in chalcogenide negative curvature fibers.

We find conditions for suppression of higher-order core modes in chalcogenide negative curvature fibers with an air core. An avoided crossing between the higher-order core modes and the fundamental modes in the tubes surrounding the core can be used to resonantly couple these modes, so that the higher-order core modes become lossy. In the parameter range of the avoided crossing, the higher-order core modes become hybrid modes that reside partly in the core and partly in the tubes. The loss ratio of the higher-order core modes to the fundamental core mode can be more than 50, while the leakage loss of the fundamental core mode is under 0.4 dB/m. We show that this loss ratio is almost unchanged when the core diameter changes and so will remain large in the presence of fluctuations that are due to the fiber drawing process.

Highly efficient cascaded amplification using Pr(3+)-doped mid-infrared chalcogenide fiber amplifiers.

We computationally investigate cascaded amplification in a three-level mid-infrared (IR) Pr(3+)-doped chalcogenide fiber amplifier. The overlap of the cross-sections in the transitions (3)H(6)→(3)H(5) and (3)H(5)→(3)H(4) enable both transitions to simultaneously amplify a single wavelength in the range between 4.25 µm and 4.55 µm. High gain and low noise are achieved simultaneously if the signal is at 4.5 µm. We show that 45% of pump power that is injected at 2 µm can be shifted to 4.5 µm. The efficiency of using a mid-IR fiber amplifier is higher than what can be achieved by using mid-IR supercontinuum generation, which has been estimated at 25%. This mid-IR fiber amplifier can be used in conjunction with quantum cascade lasers to obtain a tunable, high-power mid-IR source.

Case Report: Pirfenidone in the Treatment of Post-COVID-19 Pulmonary Fibrosis.

Background: Pulmonary fibrosis is one of the sequelae of the COVID-19, which seriously affects the quality of life of survivors. Currently, there are no optimal evidence based guidelines targeting this population. Case Presentation: We report a 66-year-old female patient without underlying comorbidities admitted to Changsha Public Health Center because of COVID-19. During hospitalization, she developed co-bacterial infection and acute respiratory distress syndrome, and received broad-spectrum antibacterial therapy, invasive mechanical ventilation and extracorporeal membrane oxygenation. After the acute phase, she developed post-COVID-19 pulmonary fibrosis subsequently treated with pirfenidone. Over 96 weeks after pirfenidone treatment, her modified Medical Research Council Dyspnea level improved to 2 from 4 at discharge. Her 6 minutes walk test distance, total lung capacity, and diffusion capacity for carbon monoxide all increased. Chest CT performed on 2 years after illness onset showed regressing fibrosis. The Hospital Anxiety and Depression Scale, Athens Insomnia Scale, and 36-Item Short Form Health Survey questionnaire all improved. Conclusion: Post-COVID-19 pulmonary fibrosis is a challenging consequence of COVID-19, and our case suggests that pirfenidone may be an effective treatment option.