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1.

Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations.

Rausch, Tobias; Jones, David T W; Zapatka, Marc; Stütz, Adrian M; Zichner, Thomas; Weischenfeldt, Joachim; Jäger, Natalie; Remke, Marc; Shih, David; Northcott, Paul A; Pfaff, Elke; Tica, Jelena; Wang, Qi; Massimi, Luca; Witt, Hendrik; Bender, Sebastian; Pleier, Sabrina; Cin, Huriye; Hawkins, Cynthia; Beck, Christian; von Deimling, Andreas; Hans, Volkmar; Brors, Benedikt; Eils, Roland; Scheurlen, Wolfram; Blake, Jonathon; Benes, Vladimir; Kulozik, Andreas E; Witt, Olaf; Martin, Dianna; Zhang, Cindy; Porat, Rinnat; Merino, Diana M; Wasserman, Jonathan; Jabado, Nada; Fontebasso, Adam; Bullinger, Lars; Rücker, Frank G; Döhner, Konstanze; Döhner, Hartmut; Koster, Jan; Molenaar, Jan J; Versteeg, Rogier; Kool, Marcel; Tabori, Uri; Malkin, David; Korshunov, Andrey; Taylor, Michael D; Lichter, Peter; Pfister, Stefan M.

Cell ; 148(1-2): 59-71, 2012 Jan 20.

Article in English | MEDLINE | ID: mdl-22265402

2.

Patterns of somatic structural variation in human cancer genomes.

Li, Yilong; Roberts, Nicola D; Wala, Jeremiah A; Shapira, Ofer; Schumacher, Steven E; Kumar, Kiran; Khurana, Ekta; Waszak, Sebastian; Korbel, Jan O; Haber, James E; Imielinski, Marcin; Weischenfeldt, Joachim; Beroukhim, Rameen; Campbell, Peter J.

Nature ; 578(7793): 112-121, 2020 02.

Article in English | MEDLINE | ID: mdl-32025012

3.

Somatic structural variant formation is guided by and influences genome architecture.

Sidiropoulos, Nikos; Mardin, Balca R; Rodríguez-González, F Germán; Bochkov, Ivan D; Garg, Shilpa; Stütz, Adrian M; Korbel, Jan O; Aiden, Erez Lieberman; Weischenfeldt, Joachim.

Genome Res ; 32(4): 643-655, 2022 04.

Article in English | MEDLINE | ID: mdl-35177558

4.

Author Correction: Patterns of somatic structural variation in human cancer genomes.

Li, Yilong; Roberts, Nicola D; Wala, Jeremiah A; Shapira, Ofer; Schumacher, Steven E; Kumar, Kiran; Khurana, Ekta; Waszak, Sebastian; Korbel, Jan O; Haber, James E; Imielinski, Marcin; Weischenfeldt, Joachim; Beroukhim, Rameen; Campbell, Peter J.

Nature ; 614(7948): E38, 2023 Feb.

Article in English | MEDLINE | ID: mdl-36697835

5.

Author Correction: The landscape of genomic alterations across childhood cancers.

Gröbner, Susanne N; Worst, Barbara C; Weischenfeldt, Joachim; Buchhalter, Ivo; Kleinheinz, Kortine; Rudneva, Vasilisa A; Johann, Pascal D; Balasubramanian, Gnana Prakash; Segura-Wang, Maia; Brabetz, Sebastian; Bender, Sebastian; Hutter, Barbara; Sturm, Dominik; Pfaff, Elke; Hübschmann, Daniel; Zipprich, Gideon; Heinold, Michael; Eils, Jürgen; Lawerenz, Christian; Erkek, Serap; Lambo, Sander; Waszak, Sebastian; Blattmann, Claudia; Borkhardt, Arndt; Kuhlen, Michaela; Eggert, Angelika; Fulda, Simone; Gessler, Manfred; Wegert, Jenny; Kappler, Roland; Baumhoer, Daniel; Burdach, Stefan; Kirschner-Schwabe, Renate; Kontny, Udo; Kulozik, Andreas E; Lohmann, Dietmar; Hettmer, Simone; Eckert, Cornelia; Bielack, Stefan; Nathrath, Michaela; Niemeyer, Charlotte; Richter, Günther H; Schulte, Johannes; Siebert, Reiner; Westermann, Frank; Molenaar, Jan J; Vassal, Gilles; Witt, Hendrik; Burkhardt, Birgit; Kratz, Christian P.

Nature ; 559(7714): E10, 2018 07.

Article in English | MEDLINE | ID: mdl-29875405

6.

The landscape of genomic alterations across childhood cancers.

Gröbner, Susanne N; Worst, Barbara C; Weischenfeldt, Joachim; Buchhalter, Ivo; Kleinheinz, Kortine; Rudneva, Vasilisa A; Johann, Pascal D; Balasubramanian, Gnana Prakash; Segura-Wang, Maia; Brabetz, Sebastian; Bender, Sebastian; Hutter, Barbara; Sturm, Dominik; Pfaff, Elke; Hübschmann, Daniel; Zipprich, Gideon; Heinold, Michael; Eils, Jürgen; Lawerenz, Christian; Erkek, Serap; Lambo, Sander; Waszak, Sebastian; Blattmann, Claudia; Borkhardt, Arndt; Kuhlen, Michaela; Eggert, Angelika; Fulda, Simone; Gessler, Manfred; Wegert, Jenny; Kappler, Roland; Baumhoer, Daniel; Burdach, Stefan; Kirschner-Schwabe, Renate; Kontny, Udo; Kulozik, Andreas E; Lohmann, Dietmar; Hettmer, Simone; Eckert, Cornelia; Bielack, Stefan; Nathrath, Michaela; Niemeyer, Charlotte; Richter, Günther H; Schulte, Johannes; Siebert, Reiner; Westermann, Frank; Molenaar, Jan J; Vassal, Gilles; Witt, Hendrik; Burkhardt, Birgit; Kratz, Christian P.

Nature ; 555(7696): 321-327, 2018 03 15.

Article in English | MEDLINE | ID: mdl-29489754

7.

PD-L1 expression in tumor and inflammatory cells is associated with favorable tumor features and favorable prognosis in muscle-invasive urothelial carcinoma of the bladder not treated by immune checkpoint inhibitors.

Plage, Henning; Furlano, Kira; Hofbauer, Sebastian; Weinberger, Sarah; Ralla, Bernhard; Franz, Antonia; Fendler, Annika; de Martino, Michela; Roßner, Florian; Elezkurtaj, Sefer; Kluth, Martina; Lennartz, Maximilian; Blessin, Niclas C; Marx, Andreas H; Samtleben, Henrik; Fisch, Margit; Rink, Michael; Slojewski, Marcin; Kaczmarek, Krystian; Ecke, Thorsten; Hallmann, Steffen; Koch, Stefan; Adamini, Nico; Zecha, Henrik; Minner, Sarah; Simon, Ronald; Sauter, Guido; Weischenfeldt, Joachim; Klatte, Tobias; Schlomm, Thorsten; Horst, David; Schallenberg, Simon.

BMC Urol ; 24(1): 96, 2024 Apr 24.

Article in English | MEDLINE | ID: mdl-38658905

8.

The whole-genome landscape of medulloblastoma subtypes.

Northcott, Paul A; Buchhalter, Ivo; Morrissy, A Sorana; Hovestadt, Volker; Weischenfeldt, Joachim; Ehrenberger, Tobias; Gröbner, Susanne; Segura-Wang, Maia; Zichner, Thomas; Rudneva, Vasilisa A; Warnatz, Hans-Jörg; Sidiropoulos, Nikos; Phillips, Aaron H; Schumacher, Steven; Kleinheinz, Kortine; Waszak, Sebastian M; Erkek, Serap; Jones, David T W; Worst, Barbara C; Kool, Marcel; Zapatka, Marc; Jäger, Natalie; Chavez, Lukas; Hutter, Barbara; Bieg, Matthias; Paramasivam, Nagarajan; Heinold, Michael; Gu, Zuguang; Ishaque, Naveed; Jäger-Schmidt, Christina; Imbusch, Charles D; Jugold, Alke; Hübschmann, Daniel; Risch, Thomas; Amstislavskiy, Vyacheslav; Gonzalez, Francisco German Rodriguez; Weber, Ursula D; Wolf, Stephan; Robinson, Giles W; Zhou, Xin; Wu, Gang; Finkelstein, David; Liu, Yanling; Cavalli, Florence M G; Luu, Betty; Ramaswamy, Vijay; Wu, Xiaochong; Koster, Jan; Ryzhova, Marina; Cho, Yoon-Jae.

Nature ; 547(7663): 311-317, 2017 07 19.

Article in English | MEDLINE | ID: mdl-28726821

9.

Clonal hematopoiesis in elderly twins: concordance, discordance, and mortality.

Hansen, Jakob Werner; Pedersen, Dorthe Almind; Larsen, Lisbeth Aagaard; Husby, Simon; Clemmensen, Signe Bedsted; Hjelmborg, Jacob; Favero, Francesco; Weischenfeldt, Joachim; Christensen, Kaare; Grønbæk, Kirsten.

Blood ; 135(4): 261-268, 2020 01 23.

Article in English | MEDLINE | ID: mdl-31697811

10.

SvABA: genome-wide detection of structural variants and indels by local assembly.

Wala, Jeremiah A; Bandopadhayay, Pratiti; Greenwald, Noah F; O'Rourke, Ryan; Sharpe, Ted; Stewart, Chip; Schumacher, Steve; Li, Yilong; Weischenfeldt, Joachim; Yao, Xiaotong; Nusbaum, Chad; Campbell, Peter; Getz, Gad; Meyerson, Matthew; Zhang, Cheng-Zhong; Imielinski, Marcin; Beroukhim, Rameen.

Genome Res ; 28(4): 581-591, 2018 04.

Article in English | MEDLINE | ID: mdl-29535149

11.

Phenotypic impact of genomic structural variation: insights from and for human disease.

Weischenfeldt, Joachim; Symmons, Orsolya; Spitz, François; Korbel, Jan O.

Nat Rev Genet ; 14(2): 125-38, 2013 Feb.

Article in English | MEDLINE | ID: mdl-23329113

12.

Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort.

Waszak, Sebastian M; Northcott, Paul A; Buchhalter, Ivo; Robinson, Giles W; Sutter, Christian; Groebner, Susanne; Grund, Kerstin B; Brugières, Laurence; Jones, David T W; Pajtler, Kristian W; Morrissy, A Sorana; Kool, Marcel; Sturm, Dominik; Chavez, Lukas; Ernst, Aurelie; Brabetz, Sebastian; Hain, Michael; Zichner, Thomas; Segura-Wang, Maia; Weischenfeldt, Joachim; Rausch, Tobias; Mardin, Balca R; Zhou, Xin; Baciu, Cristina; Lawerenz, Christian; Chan, Jennifer A; Varlet, Pascale; Guerrini-Rousseau, Lea; Fults, Daniel W; Grajkowska, Wieslawa; Hauser, Peter; Jabado, Nada; Ra, Young-Shin; Zitterbart, Karel; Shringarpure, Suyash S; De La Vega, Francisco M; Bustamante, Carlos D; Ng, Ho-Keung; Perry, Arie; MacDonald, Tobey J; Hernáiz Driever, Pablo; Bendel, Anne E; Bowers, Daniel C; McCowage, Geoffrey; Chintagumpala, Murali M; Cohn, Richard; Hassall, Timothy; Fleischhack, Gudrun; Eggen, Tone; Wesenberg, Finn.

Lancet Oncol ; 19(6): 785-798, 2018 06.

Article in English | MEDLINE | ID: mdl-29753700

13.

Dissecting the genomic complexity underlying medulloblastoma.

Jones, David T W; Jäger, Natalie; Kool, Marcel; Zichner, Thomas; Hutter, Barbara; Sultan, Marc; Cho, Yoon-Jae; Pugh, Trevor J; Hovestadt, Volker; Stütz, Adrian M; Rausch, Tobias; Warnatz, Hans-Jörg; Ryzhova, Marina; Bender, Sebastian; Sturm, Dominik; Pleier, Sabrina; Cin, Huriye; Pfaff, Elke; Sieber, Laura; Wittmann, Andrea; Remke, Marc; Witt, Hendrik; Hutter, Sonja; Tzaridis, Theophilos; Weischenfeldt, Joachim; Raeder, Benjamin; Avci, Meryem; Amstislavskiy, Vyacheslav; Zapatka, Marc; Weber, Ursula D; Wang, Qi; Lasitschka, Bärbel; Bartholomae, Cynthia C; Schmidt, Manfred; von Kalle, Christof; Ast, Volker; Lawerenz, Chris; Eils, Jürgen; Kabbe, Rolf; Benes, Vladimir; van Sluis, Peter; Koster, Jan; Volckmann, Richard; Shih, David; Betts, Matthew J; Russell, Robert B; Coco, Simona; Tonini, Gian Paolo; Schüller, Ulrich; Hans, Volkmar.

Nature ; 488(7409): 100-5, 2012 Aug 02.

Article in English | MEDLINE | ID: mdl-22832583

14.

Clonal hematopoiesis evolves from pretreatment clones and stabilizes after end of chemotherapy in patients with MCL.

Eskelund, Christian Winther; Husby, Simon; Favero, Francesco; Klausen, Tobias Wirenfeldt; Rodriguez-Gonzalez, Francisco German; Kolstad, Arne; Pedersen, Lone Bredo; Räty, Riikka Katariina; Geisler, Christian H; Jerkeman, Mats; Weischenfeldt, Joachim; Grønbæk, Kirsten.

Blood ; 135(22): 2000-2004, 2020 05 28.

Article in English | MEDLINE | ID: mdl-32181815

15.

Genomes of early onset prostate cancer.

Weischenfeldt, Joachim; Korbel, Jan O.

Curr Opin Urol ; 27(5): 481-487, 2017 Sep.

Article in English | MEDLINE | ID: mdl-28661899

16.

A cell-based model system links chromothripsis with hyperploidy.

Mardin, Balca R; Drainas, Alexandros P; Waszak, Sebastian M; Weischenfeldt, Joachim; Isokane, Mayumi; Stütz, Adrian M; Raeder, Benjamin; Efthymiopoulos, Theocharis; Buccitelli, Christopher; Segura-Wang, Maia; Northcott, Paul; Pfister, Stefan M; Lichter, Peter; Ellenberg, Jan; Korbel, Jan O.

Mol Syst Biol ; 11(9): 828, 2015 Sep 28.

Article in English | MEDLINE | ID: mdl-26415501

17.

Heterogeneity of ERG expression in prostate cancer: a large section mapping study of entire prostatectomy specimens from 125 patients.

Tsourlakis, Maria-Christina; Stender, Annegret; Quaas, Alexander; Kluth, Martina; Wittmer, Corinna; Haese, Alexander; Graefen, Markus; Steurer, Stefan; Simon, Ronald; Korbel, Jan; Weischenfeldt, Joachim; Huland, Hartwig; Sauter, Guido; Schlomm, Thorsten; Minner, Sarah.

BMC Cancer ; 16: 641, 2016 08 17.

Article in English | MEDLINE | ID: mdl-27530104

18.

Pediatric T-cell lymphoblastic leukemia evolves into relapse by clonal selection, acquisition of mutations and promoter hypomethylation.

Kunz, Joachim B; Rausch, Tobias; Bandapalli, Obul R; Eilers, Juliane; Pechanska, Paulina; Schuessele, Stephanie; Assenov, Yassen; Stütz, Adrian M; Kirschner-Schwabe, Renate; Hof, Jana; Eckert, Cornelia; von Stackelberg, Arend; Schrappe, Martin; Stanulla, Martin; Koehler, Rolf; Avigad, Smadar; Elitzur, Sarah; Handgretinger, Rupert; Benes, Vladimir; Weischenfeldt, Joachim; Korbel, Jan O; Muckenthaler, Martina U; Kulozik, Andreas E.

Haematologica ; 100(11): 1442-50, 2015 Nov.

Article in English | MEDLINE | ID: mdl-26294725

19.

Immunotherapy drives mesenchymal tumour cell state shift and TME immune response in glioblastoma patients.

Hendriksen, Josephine D; Locallo, Alessio; Maarup, Simone; Debnath, Olivia; Ishaque, Naveed; Hasselbach, Benedikte; Skjøth-Rasmussen, Jane; Yde, Christina Westmose; Poulsen, Hans S; Lassen, Ulrik; Weischenfeldt, Joachim.

Neuro Oncol ; 2024 May 02.

Article in English | MEDLINE | ID: mdl-38695342

20.

Loss of Upk1a and Upk1b expression is linked to stage progression in urothelial carcinoma of the bladder.

Kaczmarek, Krystian; Plage, Henning; Furlano, Kira; Hofbauer, Sebastian; Weinberger, Sarah; Ralla, Bernhard; Franz, Antonia; Fendler, Annika; de Martino, Michela; Roßner, Florian; Schallenberg, Simon; Elezkurtaj, Sefer; Kluth, Martina; Lennartz, Maximilian; Blessin, Niclas C; Marx, Andreas H; Samtleben, Henrik; Fisch, Margit; Rink, Michael; Slojewski, Marcin; Ecke, Thorsten; Hallmann, Steffen; Koch, Stefan; Adamini, Nico; Minner, Sarah; Simon, Ronald; Sauter, Guido; Weischenfeldt, Joachim; Klatte, Tobias; Schlomm, Thorsten; Horst, David; Zecha, Henrik.

Int Urol Nephrol ; 56(2): 499-508, 2024 Feb.

Article in English | MEDLINE | ID: mdl-37777995

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