Cognitive functioning in children with self-limited epilepsy with centrotemporal spikes: A systematic review and meta-analysis.

OBJECTIVE: It is now well appreciated that benign epilepsy with centrotemporal spikes (BECTS, or more recently, ECTS) is associated with a range of cognitive and behavioral disturbances. Despite our improved understanding of cognitive functioning in ECTS, there have been to date no efforts to quantitatively synthesize the available literature within a comprehensive cognitive framework. METHODS: The present systematic review and meta-analysis was conducted according to PRISMA guidelines. Forty-two case-control samples met eligibility criteria comprising a total of 1,237 children with ECTS and 1,137 healthy control children. Univariate, random-effects meta-analyses were conducted on eight cognitive factors in accordance with the Cattell-Horn-Carroll model of intelligence. RESULTS: Overall, children with ECTS demonstrated significantly lower scores on neuropsychological tests across all cognitive factors compared to healthy controls. Observed effects ranged from 0.42 to 0.81 pooled standard deviation units, with the largest effect for long-term storage and retrieval and the smallest effect for visual processing. SIGNIFICANCE: The results of the present meta-analysis provide the first clear evidence that children with ECTS display a profile of pervasive cognitive difficulties and thus challenge current conceptions of ECTS as a benign disease or of limited specific or localized cognitive effect.

What Do You Mean by That?! An Electrophysiological Study of Emotional and Attitudinal Prosody.

The use of prosody during verbal communication is pervasive in everyday language and whilst there is a wealth of research examining the prosodic processing of emotional information, much less is known about the prosodic processing of attitudinal information. The current study investigated the online neural processes underlying the prosodic processing of non-verbal emotional and attitudinal components of speech via the analysis of event-related brain potentials related to the processing of anger and sarcasm. To examine these, sentences with prosodic expectancy violations created by cross-splicing a prosodically neutral head ('he has') and a prosodically neutral, angry, or sarcastic ending (e.g., 'a serious face') were used. Task demands were also manipulated, with participants in one experiment performing prosodic classification and participants in another performing probe-verification. Overall, whilst minor differences were found across the tasks, the results suggest that angry and sarcastic prosodic expectancy violations follow a similar processing time-course underpinned by similar neural resources.