Search details
1.
Activation of the GLP-1 receptor by a non-peptidic agonist.
Nature
; 577(7790): 432-436, 2020 01.
Article
in English
| MEDLINE | ID: mdl-31915381
2.
Structural determinants of dual incretin receptor agonism by tirzepatide.
Proc Natl Acad Sci U S A
; 119(13): e2116506119, 2022 03 29.
Article
in English
| MEDLINE | ID: mdl-35333651
3.
Mutual Cooperativity of Three Allosteric Sites on the Dopamine D1 Receptor.
Mol Pharmacol
; 103(3): 176-187, 2023 03.
Article
in English
| MEDLINE | ID: mdl-36804203
4.
Structural basis for GLP-1 receptor activation by LY3502970, an orally active nonpeptide agonist.
Proc Natl Acad Sci U S A
; 117(47): 29959-29967, 2020 11 24.
Article
in English
| MEDLINE | ID: mdl-33177239
5.
Structural insights into probe-dependent positive allosterism of the GLP-1 receptor.
Nat Chem Biol
; 16(10): 1105-1110, 2020 10.
Article
in English
| MEDLINE | ID: mdl-32690941
6.
A synthetic method to assay adhesion-family G-protein coupled receptors. Determination of the G-protein coupling profile of ADGRG6(GPR126).
Biochem Biophys Res Commun
; 534: 317-322, 2021 01 01.
Article
in English
| MEDLINE | ID: mdl-33248691
7.
Synthetic protease-activated class B GPCRs.
Biochem Biophys Res Commun
; 530(1): 246-251, 2020 09 10.
Article
in English
| MEDLINE | ID: mdl-32828294
8.
Positive Allosteric Modulation of the Glucagon-like Peptide-1 Receptor by Diverse Electrophiles.
J Biol Chem
; 291(20): 10700-15, 2016 May 13.
Article
in English
| MEDLINE | ID: mdl-26975372
9.
Progesterone receptor membrane component 1 is a functional part of the glucagon-like peptide-1 (GLP-1) receptor complex in pancreatic ß cells.
Mol Cell Proteomics
; 13(11): 3049-62, 2014 Nov.
Article
in English
| MEDLINE | ID: mdl-25044020
10.
Crystal structure of the human PRMT5:MEP50 complex.
Proc Natl Acad Sci U S A
; 109(44): 17960-5, 2012 Oct 30.
Article
in English
| MEDLINE | ID: mdl-23071334
11.
Heterotrimeric G-protein signaling is critical to pathogenic processes in Entamoeba histolytica.
PLoS Pathog
; 8(11): e1003040, 2012.
Article
in English
| MEDLINE | ID: mdl-23166501
12.
A P-loop mutation in Gα subunits prevents transition to the active state: implications for G-protein signaling in fungal pathogenesis.
PLoS Pathog
; 8(2): e1002553, 2012 Feb.
Article
in English
| MEDLINE | ID: mdl-22383884
13.
The insulin secretory action of novel polycyclic guanidines: discovery through open innovation phenotypic screening, and exploration of structure-activity relationships.
Bioorg Med Chem Lett
; 24(4): 1031-6, 2014 Feb 15.
Article
in English
| MEDLINE | ID: mdl-24484900
14.
Differential activation and modulation of the glucagon-like peptide-1 receptor by small molecule ligands.
Mol Pharmacol
; 83(4): 822-34, 2013 Apr.
Article
in English
| MEDLINE | ID: mdl-23348499
15.
Regulator of G-protein signaling-21 (RGS21) is an inhibitor of bitter gustatory signaling found in lingual and airway epithelia.
J Biol Chem
; 287(50): 41706-19, 2012 Dec 07.
Article
in English
| MEDLINE | ID: mdl-23095746
16.
Regulators of G-protein signaling accelerate GPCR signaling kinetics and govern sensitivity solely by accelerating GTPase activity.
Proc Natl Acad Sci U S A
; 107(15): 7066-71, 2010 Apr 13.
Article
in English
| MEDLINE | ID: mdl-20351284
17.
The incretin co-agonist tirzepatide requires GIPR for hormone secretion from human islets.
Nat Metab
; 5(6): 945-954, 2023 06.
Article
in English
| MEDLINE | ID: mdl-37277609
18.
Small molecule allosteric modulation of the glucagon-like Peptide-1 receptor enhances the insulinotropic effect of oxyntomodulin.
Mol Pharmacol
; 82(6): 1066-73, 2012 Dec.
Article
in English
| MEDLINE | ID: mdl-22930710
19.
Allosteric modulation of endogenous metabolites as an avenue for drug discovery.
Mol Pharmacol
; 82(2): 281-90, 2012 Aug.
Article
in English
| MEDLINE | ID: mdl-22576254
20.
Structural determinants of affinity enhancement between GoLoco motifs and G-protein alpha subunit mutants.
J Biol Chem
; 286(5): 3351-8, 2011 Feb 04.
Article
in English
| MEDLINE | ID: mdl-21115486