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1.

Integrative Molecular Structure Elucidation and Construction of an Extended Metabolic Pathway Associated with an Ancient Innate Immune Response in COVID-19 Patients.

Sala, Samuele; Nitschke, Philipp; Masuda, Reika; Gray, Nicola; Lawler, Nathan G; Wood, James M; Buckler, Joshua N; Berezhnoy, Georgy; Bolaños, Jose; Boughton, Berin A; Lonati, Caterina; Rössler, Titus; Singh, Yogesh; Wilson, Ian D; Lodge, Samantha; Morillon, Aude-Claire; Loo, Ruey Leng; Hall, Drew; Whiley, Luke; Evans, Gary B; Grove, Tyler L; Almo, Steven C; Harris, Lawrence D; Holmes, Elaine; Merle, Uta; Trautwein, Christoph; Nicholson, Jeremy K; Wist, Julien.

J Proteome Res ; 23(3): 956-970, 2024 Mar 01.

Article in English | MEDLINE | ID: mdl-38310443

2.

Establishing a framework for best practices for quality assurance and quality control in untargeted metabolomics.

Mosley, Jonathan D; Schock, Tracey B; Beecher, Chris W; Dunn, Warwick B; Kuligowski, Julia; Lewis, Matthew R; Theodoridis, Georgios; Ulmer Holland, Candice Z; Vuckovic, Dajana; Wilson, Ian D; Zanetti, Krista A.

Metabolomics ; 20(2): 20, 2024 Feb 12.

Article in English | MEDLINE | ID: mdl-38345679

3.

In vitro and in vivo studies on the metabolism and pharmacokinetics of the selective gut microbial ß-glucuronidase targeting compound Inh 1.

Kerins, Anna; Butler, Phil; Riley, Rob; Koszyczarek, Marta; Smith, Caroline; Cruickshank, Faye; Madgula, Vamsi; Naik, Nilkanth; Redinbo, Matthew; Wilson, Ian D.

Xenobiotica ; : 1-17, 2024 May 25.

Article in English | MEDLINE | ID: mdl-38794972

4.

Ensuring Fact-Based Metabolite Identification in Liquid Chromatography-Mass Spectrometry-Based Metabolomics.

Theodoridis, Georgios; Gika, Helen; Raftery, Daniel; Goodacre, Royston; Plumb, Robert S; Wilson, Ian D.

Anal Chem ; 95(8): 3909-3916, 2023 02 28.

Article in English | MEDLINE | ID: mdl-36791228

5.

Metabolic phenotyping in health and disease.

Holmes, Elaine; Wilson, Ian D; Nicholson, Jeremy K.

Cell ; 134(5): 714-7, 2008 Sep 05.

Article in English | MEDLINE | ID: mdl-18775301

6.

Investigation of the pharmacokinetics and metabolic fate of Fasiglifam (TAK-875) in male and female rats following oral and intravenous administration.

Molloy, Billy J; King, Adam; Gethings, Lee A; Plumb, Robert S; Mortishire-Smith, Russell J; Wilson, Ian D.

Xenobiotica ; 53(2): 93-105, 2023 Feb.

Article in English | MEDLINE | ID: mdl-36794569

7.

Targeted inhibition of gut bacterial ß-glucuronidase activity enhances anticancer drug efficacy.

Bhatt, Aadra P; Pellock, Samuel J; Biernat, Kristen A; Walton, William G; Wallace, Bret D; Creekmore, Benjamin C; Letertre, Marine M; Swann, Jonathan R; Wilson, Ian D; Roques, Jose R; Darr, David B; Bailey, Sean T; Montgomery, Stephanie A; Roach, Jeffrey M; Azcarate-Peril, M Andrea; Sartor, R Balfour; Gharaibeh, Raad Z; Bultman, Scott J; Redinbo, Matthew R.

Proc Natl Acad Sci U S A ; 117(13): 7374-7381, 2020 03 31.

Article in English | MEDLINE | ID: mdl-32170007

8.

Is Current Practice Adhering to Guidelines Proposed for Metabolite Identification in LC-MS Untargeted Metabolomics? A Meta-Analysis of the Literature.

Kodra, Dritan; Pousinis, Petros; Vorkas, Panagiotis A; Kademoglou, Katerina; Liapikos, Theodoros; Pechlivanis, Alexandros; Virgiliou, Christina; Wilson, Ian D; Gika, Helen; Theodoridis, Georgios.

J Proteome Res ; 21(3): 590-598, 2022 03 04.

Article in English | MEDLINE | ID: mdl-34928621

9.

High Throughput UHPLC-MS-Based Lipidomics Using Vacuum Jacketed Columns.

Plumb, Robert S; Isaac, Giorgis; Rainville, Paul D; Hill, Jason; Gethings, Lee A; Johnson, Kelly A; Lauterbach, Joshua; Wilson, Ian D.

J Proteome Res ; 21(3): 691-701, 2022 Mar 04.

Article in English | MEDLINE | ID: mdl-34968064

10.

High Throughput LC-MS Platform for Large Scale Screening of Bioactive Polar Lipids in Human Plasma and Serum.

Munjoma, Nyasha; Isaac, Giorgis; Muazzam, Ammara; Cexus, Olivier; Azhar, Fowz; Pandha, Hardev; Whetton, Anthony D; Townsend, Paul A; Wilson, Ian D; Gethings, Lee A; Plumb, Robert S.

J Proteome Res ; 21(11): 2596-2608, 2022 11 04.

Article in English | MEDLINE | ID: mdl-36264332

11.

Ion-Pairing Chromatography and Amine Derivatization Provide Complementary Approaches for the Targeted LC-MS Analysis of the Polar Metabolome.

Sagi-Kiss, Virag; Li, Yufeng; Carey, Matthew R; Grover, Sarah J; Siems, Karsten; Cirulli, Francesca; Berry, Alessandra; Musillo, Chiara; Wilson, Ian D; Want, Elizabeth J; Bundy, Jacob G.

J Proteome Res ; 21(6): 1428-1437, 2022 06 03.

Article in English | MEDLINE | ID: mdl-35536659

12.

Quality assurance and quality control reporting in untargeted metabolic phenotyping: mQACC recommendations for analytical quality management.

Kirwan, Jennifer A; Gika, Helen; Beger, Richard D; Bearden, Dan; Dunn, Warwick B; Goodacre, Royston; Theodoridis, Georgios; Witting, Michael; Yu, Li-Rong; Wilson, Ian D.

Metabolomics ; 18(9): 70, 2022 08 27.

Article in English | MEDLINE | ID: mdl-36029375

13.

The in vitro metabolism and in vivo pharmacokinetics of the bacterial ß-glucuronidase inhibitor UNC10201652.

Kerins, Anna; Koszyczarek, Marta; Smith, Caroline; Butler, Phil; Riley, Rob; Madgula, Vamsi; Naik, Nilkanth; Redinbo, Matthew R; Wilson, Ian D.

Xenobiotica ; 52(8): 904-915, 2022 Aug.

Article in English | MEDLINE | ID: mdl-36149349

14.

High-Throughput Microbore Ultrahigh-Performance Liquid Chromatography-Ion Mobility-Enabled-Mass Spectrometry-Based Proteomics Methodology for the Exploratory Analysis of Serum Samples from Large Cohort Studies.

Lennon, Sarah; Hughes, Christopher J; Muazzam, Ammara; Townsend, Paul A; Gethings, Lee A; Wilson, Ian D; Plumb, Robert S.

J Proteome Res ; 20(3): 1705-1715, 2021 03 05.

Article in English | MEDLINE | ID: mdl-33566619

15.

Sensitive and Reproducible Mass Spectrometry-Compatible RP-UHPLC Analysis of Tricarboxylic Acid Cycle and Related Metabolites in Biological Fluids: Application to Human Urine.

Smith, Kerri M; Wilson, Ian D; Rainville, Paul D.

Anal Chem ; 93(2): 1009-1015, 2021 01 19.

Article in English | MEDLINE | ID: mdl-33290053

16.

Use of Cyclic Ion Mobility Spectrometry (cIM)-Mass Spectrometry to Study the Intramolecular Transacylation of Diclofenac Acyl Glucuronide.

Higton, David; Palmer, Martin E; Vissers, Johannes P C; Mullin, Lauren G; Plumb, Robert S; Wilson, Ian D.

Anal Chem ; 93(20): 7413-7421, 2021 05 25.

Article in English | MEDLINE | ID: mdl-33984239

17.

High-Throughput UHPLC/MS/MS-Based Metabolic Profiling Using a Vacuum Jacketed Column.

Plumb, Robert S; McDonald, Thomas; Rainville, Paul D; Hill, Jason; Gethings, Lee A; Johnson, Kelly A; Wilson, Ian D.

Anal Chem ; 93(30): 10644-10652, 2021 08 03.

Article in English | MEDLINE | ID: mdl-34279080

18.

Metabolic consequences for mice lacking Endosialin: LC-MS/MS-based metabolic phenotyping of serum from C56Bl/6J Control and CD248 knock-out mice.

Armitage, Emily G; Barnes, Alan; Patrick, Kieran; Bechar, Janak; Harrison, Matthew J; Lavery, Gareth G; Rainger, G Ed; Buckley, Christopher D; Loftus, Neil J; Wilson, Ian D; Naylor, Amy J.

Metabolomics ; 17(2): 14, 2021 01 18.

Article in English | MEDLINE | ID: mdl-33462674

19.

Rapid determination of the pharmacokinetics and metabolic fate of gefitinib in the mouse using a combination of UPLC/MS/MS, UPLC/QToF/MS, and ion mobility (IM)-enabled UPLC/QToF/MS.

Molloy, Billy J; King, Adam; Mullin, Lauren G; Gethings, Lee A; Riley, Robert; Plumb, Robert S; Wilson, Ian D.

Xenobiotica ; 51(4): 434-446, 2021 Apr.

Article in English | MEDLINE | ID: mdl-33280466

20.

Metabolic Phenotyping Study of Mouse Brains Following Acute or Chronic Exposures to Ethanol.

Deda, Olga; Virgiliou, Christina; Armitage, Emily G; Orfanidis, Amvrosios; Taitzoglou, Ioannis; Wilson, Ian D; Loftus, Neil; Gika, Helen G.

J Proteome Res ; 19(10): 4071-4081, 2020 10 02.

Article in English | MEDLINE | ID: mdl-32786683

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