Evolocumab on top of empagliflozin improves endothelial function of individuals with diabetes: randomized active-controlled trial.

BACKGROUND: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) improve endothelial dysfunction and reduce cardiovascular events in individuals with type 2 diabetes (T2D). Proprotein convertase subtilisin/kexin 9 (PCSK9i) inhibitors reduce cardiovascular events in high-risk patients. Whether the addition of PCSK9i to SGLT2i treatment adds benefits is not known. OBJECTIVES: To assess the PCSK9-i effect on the endothelial function of T2D individuals under treatment with SGLT2-i. METHODS: Individuals with T2D were randomized in a 1:1 ratio to a 16-week treatment with either empagliflozin (E) or empagliflozin plus evolocumab (EE). The primary endpoint was post-treatment change from baseline in flow-mediated dilation (FMD) at 1-min. Secondary outcomes included changes in plasma levels of nitric oxide metabolites and isoprostane. RESULTS: A total of 110 patients were enrolled, the mean age was 58 years, and 71% were men. The median post-treatment change in FMD at 1-min was 2.7% (interquartile range [IQR]: 0.9%) and 0.4% (IQR: 0.9%) in the EE and E groups, respectively (p < 0.001). There was a greater increase in plasma levels of nitrate [5.9 (16.5) vs. 2.6 (11.8); p = 0.001] and nitrite [0.14 (0.72) vs. 0.02 (0.74); p = 0.025] in the EE group than in the E group, respectively. Isoprostane reduction was more pronounced in the EE group when compared to the E group [-1.7 (5.9) vs. -1.1 (5.3); p < 0.001). CONCLUSIONS: In individuals with T2D, the addition of evolocumab on top of empagliflozin improves endothelial function.

Lung function in obese children and adolescents without respiratory disease: a systematic review.

BACKGROUND: Obesity in children and adolescents is associated with increased morbidity and mortality due to multisystemic impairment, including deleterious changes in lung function, which are poorly understood. OBJECTIVES: To perform a systematic review to assess lung function in children and adolescents affected by obesity and to verify the presence of pulmonary changes due to obesity in individuals without previous or current respiratory diseases. METHODS: A systematic search was performed in the MEDLINE-PubMed (Medical Literature Analysis and Retrieval System Online), Embase (Excerpta Medica Database) and VHL (Virtual Health Library/Brazil) databases using the terms "Lung Function" and "Pediatric Obesity" and their corresponding synonyms in each database. A period of 10 years was considered, starting in February/2008. After the application of the filters, 33 articles were selected. Using the PICOS strategy, the following information was achieved: (Patient) children and adolescents; (Intervention/exposure) obesity; (Control) healthy children and adolescents; (Outcome) pulmonary function alterations; (Studies) randomized controlled trial, longitudinal studies (prospective and retrospective studies), cross-over studies and cross-sectional studies. RESULTS: Articles from 18 countries were included. Spirometry was the most widely used tool to assess lung function. There was high variability in lung function values, with a trend towards reduced lung function markers (FEV1/FVC, FRC, ERV and RV) in obese children and adolescents. CONCLUSION: Lung function, measured by several tools, shows numerous markers with contradictory alterations. Differences concerning the reported results of lung function do not allow us to reach a consensus on lung function changes in children and adolescents with obesity, highlighting the need for more publications on this topic with a standardized methodology.

Association between Pulmonary Function and Body Composition in Children and Adolescents with and without Obesity.

Lung function in children and adolescents with obesity must consider the coexistence of two complex and related phenomena: obesity and growth. The assessment of body composition can identify changes in respiratory dynamics arising, exclusively or jointly, from adiposity and lean body mass. This study aimed to compare pulmonary function and the dysanapsis indices of children and adolescents without asthma, with and without obesity, considering body composition, pubertal development, and physical activity practice. We performed a cross-sectional study with 69 participants, 41 (59.42%) of whom have obesity. All participants carried out spirometry and the assessment of, respectively, body composition by dual-energy X-ray absorptiometry, vital signs, pubertal development, and physical activity practice. In our data, the group with obesity had higher values of forced vital capacity (FVC) and lower values of the ratio between forced expiratory volume in one second and FVC (FEV1/FVC). Analyzing the entire sample, we found a positive correlation between FVC and a negative correlation between FEV1/FVC with fat mass markers. At the same time, inspiratory capacity, expiratory reserve volume, and peak expiratory flow were correlated with lean body mass markers. In addition, participants with obesity presented a lower dysanapsis index. In conclusion, children and adolescents with obesity showed increased FVC and reduced FEV1/FVC. Our findings are possibly related to the increase in fat mass, not to lean body mass. We hypothesize that these findings are associated with the dysanaptic growth pattern, which is higher in obesity, evidenced by the reduction of the dysanapsis index.

Compliance with Cardiovascular Prevention Guidelines in Type 2 Diabetes Individuals in a Middle-Income Region: A Cross-Sectional Analysis.

Stricter control of risk factors has been pursued as a compelling strategy to mitigate cardiovascular events (CVE) in type 2 diabetes (T2D) individuals. However, the achievement rate of the recommended goals has remained low in clinical practice. This study investigated the 2019 ESC guideline recommendation attainment among T2D individuals enrolled in a national cohort held in Brazil. Data from 1030 individuals (mean age: 58 years old; 54% male; mean T2D duration: 9.7 years) were analyzed. The control rates were 30.6% for SBP, 18.8% for LDL-C, and 41% for A1c, and only 3.2% of the study participants met all three targets. Statins and high-intensity lipid-lowering therapy prescription rates were 45% and 8.2%, respectively. Longer T2D duration and those at higher CV risk were less likely to be controlled. Longer diabetes duration and higher CV risk were inversely related to the chance of achieving the recommended targets. Treatment escalation using conventional therapies would be sufficient to gain optimal control in most of the study sample. In conclusion, a minimal proportion of T2D individuals comply with guidelines-oriented CV prevention targets. Given the significant burden of the disease, and the substantial effect size predicted for these therapies, bridging this gap between guidelines and clinical practice should be considered an urgent call to public health managers.

Rationale and design of the Brazilian diabetes study: a prospective cohort of type 2 diabetes.

BACKGROUND: Optimal control of traditional risk factors only partially attenuates the exceeding cardiovascular mortality of individuals with diabetes. Employment of machine learning (ML) techniques aimed at the identification of novel features of risk prediction is a compelling target to tackle residual cardiovascular risk. The objective of this study is to identify clinical phenotypes of T2D which are more prone to developing cardiovascular disease. METHODS: The Brazilian Diabetes Study is a single-center, ongoing, prospective registry of T2D individuals. Eligible patients are 30 years old or older, with a confirmed T2D diagnosis. After an initial visit for the signature of the informed consent form and medical history registration, all volunteers undergo biochemical analysis, echocardiography, carotid ultrasound, ophthalmologist visit, dual x-ray absorptiometry, coronary artery calcium score, polyneuropathy assessment, advanced glycation end-products reader, and ambulatory blood pressure monitoring. A 5-year follow-up will be conducted by yearly phone interviews for endpoints disclosure. The primary endpoint is the difference between ML-based clinical phenotypes in the incidence of a composite of death, myocardial infarction, revascularization, and stroke. Since June/2016, 1030 patients (mean age: 57 years, diabetes duration of 9.7 years, 58% male) were enrolled in our study. The mean follow-up time was 3.7 years in October/2021. CONCLUSION: The BDS will be the first large population-based cohort dedicated to the identification of clinical phenotypes of T2D at higher risk of cardiovascular events. Data derived from this study will provide valuable information on risk estimation and prevention of cardiovascular and other diabetes-related events. CLINICALTRIALS.GOV IDENTIFIER: NCT04949152.

Neck circumference and excess weight: proposal of cutoff points for Brazilian adolescents.

OBJECTIVE: To indicate neck circumference (NC) cutoff points to identify excess weight at different stages of somatic maturation and evaluate the association between NC and body mass index (BMI). METHODS: Cross-sectional study with 1715 adolescents. BMI was classified according to the World Health Organization (WHO) criteria. Somatic maturation was obtained through the peak growth velocity (PGV). To define the cutoff points, curves of the receiver operating characteristic (ROC) model were constructed. The agreement between the anthropometric evaluation instruments was analyzed. The association between the variables was verified. RESULTS: Of the girls, 93 were in the pre-PGV stage, 266 in the PGV stage, and 481 in the post-PGV stage. Of the boys, 264 were in the pre-PGV stage, 334 in the PGV stage, and 277 in the post-PGV stage. For the pre-PGV group, the cutoff point was 28cm for females and 29cm for males; for the group during PGV, the cutoff points were 30cm for females and 33cm for males; in the post-PGV group the cutoff values were 32cm in females and 35cm in males. The prevalence of excess weight was higher in the pre-PGV stage in males and in the PGV stage in females. The correlation coefficients were higher in the pre-PGV and PGV stages. CONCLUSION: The cutoff points for NC found in this study showed good sensitivity and specificity to identify excess weight in Brazilian adolescents and can be used as a reference in epidemiological studies.

Dapagliflozin increases the lean-to total mass ratio in type 2 diabetes mellitus.

We compared the effect of dapagliflozin versus glibenclamide on the ratio of lean-to total mass in patients with type 2 diabetes mellitus, carotid subclinical atherosclerosis, HbA1c 7.0-9.0% and 40-70 years-old. Ninety-eight patients (61% male; mean age 57 ± 7 years) were randomized into dapagliflozin 10 mg/day or glibenclamide 5 mg/day on top of metformin. Body composition was measured by Dual Energy X-Ray at randomization and after 12 weeks of treatment. Glycemic control was equivalent in both groups. Dapagliflozin decreased total body mass (-2741 g [95% CI: -3360 to 1945]; p < 0.001) and lean mass (-347 g [95% CI: -761 to -106]; p < 0.001), while glibenclamide increased total body mass (1060 g [95% CI: 140 to 1836]; p < 0.001) and lean mass (929 g [95% CI: 575 to 1283]; p < 0.001) for the differences between arms. The lean-to-total mass ratio increased by 1.2% in the dapagliflozin group and 0,018% in the glibenclamide group (p < 0.001). Dapagliflozin reduced the risk of a negative balance in the lean-to total mass ratio [OR: 0.16 (95% CI: 0.05 to 0.45); p < 0.001] even after adjustment for baseline lean-to total mass ratio, waist circumference, HOMAIR, HbA1c, mean of the two hands handgrip strength and gait speed [OR: 0.13 (95% CI: 0.03-0.57); p < 0.007]. In conclusion, under equivalent glycemic control, dapagliflozin reduced total body mass but increased the ratio of lean-to-total mass when compared with glibenclamide.

Prevalence of overweight in adolescents from a Southern Brazilian city according to different anthropometric indexes.

OBJECTIVE: To identify the prevalence of overweight in adolescents according to different classification criteria for obesity and somatic maturation stages. METHODS: Cross-sectional study in 10 schools in a city from Southern Brazil, with 1715 adolescents. Height, weight, waist circumference, and neck circumference (NC) data were collected. Body Mass Index was classified according to World Health Organization (WHO) and Centers for Disease Control and Prevention criteria, and the waist-to-height ratio (WHtR) was classified according to Brazilian and European cut-off points. Somatic maturation was obtained through the Peak Height Velocity. The prevalence data were compared between sex and stages of somatic maturation; the concordance between different criteria was verified. RESULTS: The prevalence of overweight was high in both sexes; WHO criteria showed that 34.5% of boys and 29.3% of girls were overweight. For the WHtR, the prevalence was 28.4% in boys and 23.7% in girls. NC classified 13.8% of boys and 15.8% of girls as being overweight. The prevalence of overweight was higher in adolescents before complete somatic maturation. CONCLUSIONS: The prevalence of overweight was high among adolescents. The boys presented higher frequency of overweight, except if NC was used to classify them. Adolescents before somatic maturation had a higher prevalence of overweight. NC showed a lower ability to track obese adolescents.

FREQUENCY OF MEALS CONSUMED BY BRAZILIAN ADOLESCENTS AND ASSOCIATED HABITS: SYSTEMATIC REVIEW.

OBJECTIVE: To analyze the studies that identified the frequency of meals ingested by Brazilian adolescents and associated habits. DATA SOURCES: A systematic search was made in the databases and electronic databases: MEDLINE/PubMed, The Latin American and Caribbean Center of Information in Health Sciences (BIREME), Scopus, Web of Science and Embase, with articles published between January/2007 until December/2017, which addressed the evaluation of the frequency of meals performed by adolescents, considering or not associations with eating patterns and meal replacement. DATA SYNTHESIS: 6,608 studies were obtained through the search and nine were included in this review, all of them with a cross-sectional design. Eight studies used school surveys and only one was a population survey. Seven studies evaluated the frequency of the main daily meals that ranged from 47.0 to 79.0% at breakfast, from 65.0 to 98.4% at lunch, and from 51.0 to 94.0% at dinner. Five studies identified the frequencies of consumption of snacks between meals, finding higher values for afternoon snack (variation from 42.0 to 78.0%). Regarding the substitution of meals for snacks, in three of the four selected studies; it was observed that this practice occurred mainly in substitution of dinner (24.6 to 42.0%). CONCLUSIONS: Breakfast was the most omitted meal for adolescents, and dinner was replaced with snacks. Among the between meal snacks, the afternoon snack was the most consumed.

EFFECTIVENESS OF OBESITY INTERVENTION PROGRAMS BASED ON GUIDELINES FOR ADOLESCENT STUDENTS: SYSTEMATIC REVIEW. / EFETIVIDADE DE PROGRAMAS DE INTERVENÇÃO PARA OBESIDADE COM BASE EM ORIENTAÇÕES PARA ESCOLARES ADOLESCENTES: REVISÃO SISTEMÁTICA.

OBJECTIVE: To verify the effectiveness of educational interventions based on guidance on physical activity and nutrition in schoolchildren. DATA SOURCES: A systematic search was carried out in four electronic databases containing articles published between October 2007 and January 2017 and addressing educational interventions with emphasis on both nutritional education and physical activity in schoolchildren and adolescents aged 10 to 19 years. DATA SYNTHESIS: Twelve articles were selected for this review, of which four included only educational interventions; four made and association between educational interventions, inclusion of healthy foods and physical activity; two made a relation between guidelines and physical activity; and finally, two associated guidelines with consumption of healthy foods. CONCLUSIONS: Interventions based on physical activity and/or nutrition counseling were efficient and showed superior results in studies that associated the practice of physical activity with counseling. However, the need for new studies on educational interventions among schoolchildren and adolescents was made evident.

OBJETIVO: Verificar a efetividade de intervenções educacionais baseadas na orientação sobre atividade física e nutrição em escolares. FONTE DE DADOS: Foi realizada busca sistemática em quatro bancos e bases de dados eletrônicos, com artigos publicados entre outubro de 2007 e janeiro de 2017 que abordaram a realização de intervenções educacionais com ênfase em educação nutricional e atividade física ou exercício físico em escolares com idades entre 10 e 19 anos. SÍNTESE DOS DADOS: Foram selecionados 12 artigos para esta revisão. Desses estudos, quatro incluíram a intervenção educacional; quatro associaram intervenções educacionais à inclusão de alimentos saudáveis e atividade física; dois estudos relacionaram as orientações e a atividade física; e, por fim, dois ligaram as orientações com o consumo de alimentos saudáveis. CONCLUSÕES: As intervenções baseadas na orientação de atividade física e/ou nutrição foram eficientes, com resultados superiores nos estudos que associaram a prática de atividade física à orientação. Entretanto, observou-se a necessidade da realização de novos estudos que abordem as intervenções educacionais em escolares.

Concordance between whole- and half-body scans to evaluate body composition in dual-energy X-ray absorptiometry in children and adolescents with different nutritional and pubertal conditions.

OBJECTIVES: Evaluation of body composition is a relevant clinical instrument for the follow-up assessments of children and adolescents, and dual-energy X-ray absorptiometry (DXA) is an accurate method for the pediatric population. However, DXA has limited scan area for the obese population. Thus, half-body scans emerged as an alternative to evaluate individuals with obesity. The aim of this study was to compare the body composition of children and adolescents with whole- and half-body DXA scans, considering nutritional status, pubertal development, sex, and age. METHODS: This was a cross-sectional, analytical, and diagnostic intervention study with a sample of 82 participants of both sexes between 4 and 20 y of age. Body composition was evaluated by DXA using an iDXA bone densitometer (GE Healthcare Lunar, Madison, WI, USA). Two evaluations were performed: whole-body and half-body scans. The Bland-Altman correlation and linear regression tests were applied to identify the presence of association bias between the techniques. α = 0.05 was set. RESULTS: Of the 82 participants, 20 were excluded. A high correlation was observed between the data (correlation coefficient ∼0.999). Bland-Altman plots and regression analyses demonstrated correlation and randomness bias between whole- and half-body scan techniques in obese or normal weight participants for all DXA markers. CONCLUSIONS: The use of half-body scans was feasible and accurate to evaluate whole-body composition. The difference bias between techniques occurred randomly and was clinically irrelevant. A high correlation was observed between half- and whole-body analysis techniques.

Assessment of dapagliflozin effect on diabetic endothelial dysfunction of brachial artery (ADDENDA-BHS2 trial): rationale, design, and baseline characteristics of a randomized controlled trial.

BACKGROUND: Endothelial dysfunction (ED) is a hallmark in type 2 diabetes mellitus (T2DM) that favor both atherogenesis and ischemia and reperfusion injury (IRI). Sodium-glucose-2 co-transporter inhibitors (SGLT2i) may hypothetically improve microvascular and macrovascular functions via a broad spectrum of mechanisms, being superior to traditional antidiabetic therapy such as sulfonylurea, even in subjects under equivalent glycemic control. Hence, the present clinical trial was designed to compare the effect of these two treatments on markers of arterial wall function and inflammation in T2DM patients as well as on the potential mediating parameters. METHOD AND RESULTS: ADDENDA-BHS2 is a prospective, single-center, active-controlled, open, randomized trial. Ninety-eight participants (40-70 years old) with HbA1c 7-9% were randomized (1:1, stratified by gender, BMI and HbA1c levels) to either dapagliflozin 10 mg/day or glibenclamide 5 mg/day on top of metformin. The primary endpoint was the change of flow-mediated dilation (FMD) after a 12-week period of treatment evaluated at rest and after IRI between dapagliflozin and glibenclamide arms. Secondary outcomes were defined as the difference between treatments regarding: plasma nitric oxide (NO) change after FMD, plasma isoprostane, plasma levels of vascular inflammatory markers and systemic inflammatory markers, plasma levels of adipokines, anthropometric measures, glucose control parameters, office and ambulatory BP control. Safety endpoints were defined as systolic and diastolic function assessed by echocardiography and retinopathy change. Serious adverse events were recorded. The study protocol was approved by the Independent Scientific Advisory Committee. CONCLUSION: The ADDENDA-BHS2 trial is an investigator-initiated clinical trial comparing the effect of dapagliflozin versus glibenclamide on several aspects of vascular function in high cardiovascular risk T2DM patients. Besides, a large clinical and biochemical phenotype assessment will be obtained for exploring potential mediations and associations.Trial registration Clinical trial registration: NCT02919345 (September, 2016).

Prevalence of overweight in adolescents from a Southern Brazilian city according to different anthropometric indexes / Prevalência de excesso de peso em adolescentes de uma cidade do sul do brasil, de acordo com diferentes índices antropométricos

ABSTRACT Objective: To identify the prevalence of overweight in adolescents according to different classification criteria for obesity and somatic maturation stages. Methods: Cross-sectional study in 10 schools in a city from Southern Brazil, with 1715 adolescents. Height, weight, waist circumference, and neck circumference (NC) data were collected. Body Mass Index was classified according to World Health Organization (WHO) and Centers for Disease Control and Prevention criteria, and the waist-to-height ratio (WHtR) was classified according to Brazilian and European cut-off points. Somatic maturation was obtained through the Peak Height Velocity. The prevalence data were compared between sex and stages of somatic maturation; the concordance between different criteria was verified. Results: The prevalence of overweight was high in both sexes; WHO criteria showed that 34.5% of boys and 29.3% of girls were overweight. For the WHtR, the prevalence was 28.4% in boys and 23.7% in girls. NC classified 13.8% of boys and 15.8% of girls as being overweight. The prevalence of overweight was higher in adolescents before complete somatic maturation. Conclusions: The prevalence of overweight was high among adolescents. The boys presented higher frequency of overweight, except if NC was used to classify them. Adolescents before somatic maturation had a higher prevalence of overweight. NC showed a lower ability to track obese adolescents.

RESUMO Objetivo: Identificar a prevalência de excesso de peso em adolescentes de acordo com diferentes critérios de classificação de obesidade e estágios de maturação somática. Métodos: Estudo transversal em dez escolas de um município da região Sul do Brasil, com 1.715 adolescentes. Dados de estatura, peso, circunferência da cintura e circunferência do pescoço (CP) foram coletados. O índice de massa corpórea (IMC) foi classificado com os critérios da Organização Mundial da Saúde (OMS) e do Centers for Disease Control and Prevention, e a razão cintura-estatura (RCE) foi classificada de acordo com pontos de corte brasileiros e europeus. A maturação somática foi obtida por meio do pico de velocidade do crescimento (PVC). Os dados de prevalência foram comparados entre os sexos e os estágios maturacionais; verificou-se a concordância entre os diferentes critérios. Resultados: A prevalência do excesso de peso foi elevada em ambos os sexos. Com o critério da OMS, a prevalência foi de 34,5% nos meninos e 29,3% nas meninas. Para a RCE, a prevalência foi de 28,4% nos meninos e 23,7% nas meninas. A CP rastreou 13,8% de excesso de peso nos meninos e 15,8% nas meninas. A prevalência de excesso de peso foi mais elevada em adolescentes antes da maturação somática completa. Conclusões: A prevalência do excesso de peso foi elevada entre os adolescentes. Os meninos apresentaram maior percentual de excesso de peso, exceto na variável CP. Adolescentes antes da maturação somática apresentaram maior prevalência de sobrepeso. A CP tem menor capacidade de rastrear adolescentes obesos.

Neck circumference and excess weight: proposal of cutoff points for Brazilian adolescents

Abstract Objective: To indicate neck circumference (NC) cutoff points to identify excess weight at different stages of somatic maturation and evaluate the association between NC and body mass index (BMI). Methods: Cross-sectional study with 1715 adolescents. BMI was classified according to the World Health Organization (WHO) criteria. Somatic maturation was obtained through the peak growth velocity (PGV). To define the cutoff points, curves of the receiver operating characteristic (ROC) model were constructed. The agreement between the anthropometric evaluation instruments was analyzed. The association between the variables was verified. Results: Of the girls, 93 were in the pre-PGV stage, 266 in the PGV stage, and 481 in the post-PGV stage. Of the boys, 264 were in the pre-PGV stage, 334 in the PGV stage, and 277 in the post-PGV stage. For the pre-PGV group, the cutoff point was 28 cm for females and 29 cm for males; for the group during PGV, the cutoff points were 30 cm for females and 33 cm for males; in the post-PGV group the cutoff values were 32 cm in females and 35 cm in males. The prevalence of excess weight was higher in the pre-PGV stage in males and in the PGV stage in females. The correlation coefficients were higher in the pre-PGV and PGV stages. Conclusion: The cutoff points for NC found in this study showed good sensitivity and specificity to identify excess weight in Brazilian adolescents and can be used as a reference in epidemiological studies.

Frequency of meals consumed by brazilian adolescents and associated habits: systematic review / Frequência das refeições realizadas por adolescentes brasileiros e hábitos associados: revisão sistemática

ABSTRACT Objective: To analyze the studies that identified the frequency of meals ingested by Brazilian adolescents and associated habits. Data sources: A systematic search was made in the databases and electronic databases: MEDLINE/PubMed, The Latin American and Caribbean Center of Information in Health Sciences (BIREME), Scopus, Web of Science and Embase, with articles published between January/2007 until December/2017, which addressed the evaluation of the frequency of meals performed by adolescents, considering or not associations with eating patterns and meal replacement. Data synthesis: 6,608 studies were obtained through the search and nine were included in this review, all of them with a cross-sectional design. Eight studies used school surveys and only one was a population survey. Seven studies evaluated the frequency of the main daily meals that ranged from 47.0 to 79.0% at breakfast, from 65.0 to 98.4% at lunch, and from 51.0 to 94.0% at dinner. Five studies identified the frequencies of consumption of snacks between meals, finding higher values for afternoon snack (variation from 42.0 to 78.0%). Regarding the substitution of meals for snacks, in three of the four selected studies; it was observed that this practice occurred mainly in substitution of dinner (24.6 to 42.0%). Conclusions: Breakfast was the most omitted meal for adolescents, and dinner was replaced with snacks. Among the between meal snacks, the afternoon snack was the most consumed.

RESUMO Objetivo: Analisar os estudos que identificaram a frequência de refeições ingeridas por adolescentes brasileiros e hábitos associados. Fonte de dados: Efetuou-se uma busca sistemática nos bancos e nas bases de dados eletrônicos MEDLINE/PubMed, The Latin American and Caribbean Center of Information in Health Sciences (BIREME), Scopus, Web of Science e Embase, com artigos publicados entre janeiro de 2007 e dezembro de 2017, que abordaram a avaliação da frequência das refeições realizadas por adolescentes, considerando ou não as associações com padrões alimentares e substituição de refeições. Síntese dos dados: Foram obtidos 6.608 estudos por meio da busca e incluídos nove nesta revisão, todos de delineamento transversal. Oito deles utilizaram inquéritos escolares e apenas um tratava-se de inquérito populacional. Sete estudos avaliaram a frequência das principais refeições diárias que oscilaram de 47,0 a 79,0% no café da manhã, de 65,0 a 98,4% no almoço e de 51,0 a 94,0% no jantar. Cinco estudos identificaram as frequências de consumo de lanches intermediários, encontrando valores mais elevados para o lanche da tarde (variação de 42,0 a 78,0%). Em relação à substituição de refeições por lanches, em três dos quatros estudos selecionados, observou-se que essa prática ocorreu principalmente no jantar (24,6 a 42,0%). Conclusões: O café da manhã foi a refeição mais omitida pelos adolescentes, e o jantar, a mais substituída por lanches. Entre os lanches intermediários, o da tarde foi o mais consumido.

Efetividade de programas de intervenção para obesidade com base em orientações para escolares adolescentes: revisão sistemática / Effectiveness of obesity intervention programs based on guidelines for adolescent students: systematic review

RESUMO Objetivo: Verificar a efetividade de intervenções educacionais baseadas na orientação sobre atividade física e nutrição em escolares. Fonte de dados: Foi realizada busca sistemática em quatro bancos e bases de dados eletrônicos, com artigos publicados entre outubro de 2007 e janeiro de 2017 que abordaram a realização de intervenções educacionais com ênfase em educação nutricional e atividade física ou exercício físico em escolares com idades entre 10 e 19 anos. Síntese dos dados: Foram selecionados 12 artigos para esta revisão. Desses estudos, quatro incluíram a intervenção educacional; quatro associaram intervenções educacionais à inclusão de alimentos saudáveis e atividade física; dois estudos relacionaram as orientações e a atividade física; e, por fim, dois ligaram as orientações com o consumo de alimentos saudáveis. Conclusões: As intervenções baseadas na orientação de atividade física e/ou nutrição foram eficientes, com resultados superiores nos estudos que associaram a prática de atividade física à orientação. Entretanto, observou-se a necessidade da realização de novos estudos que abordem as intervenções educacionais em escolares.

ABSTRACT Objective: To verify the effectiveness of educational interventions based on guidance on physical activity and nutrition in schoolchildren. Data sources: A systematic search was carried out in four electronic databases containing articles published between October 2007 and January 2017 and addressing educational interventions with emphasis on both nutritional education and physical activity in schoolchildren and adolescents aged 10 to 19 years. Data synthesis: Twelve articles were selected for this review, of which four included only educational interventions; four made and association between educational interventions, inclusion of healthy foods and physical activity; two made a relation between guidelines and physical activity; and finally, two associated guidelines with consumption of healthy foods. Conclusions: Interventions based on physical activity and/or nutrition counseling were efficient and showed superior results in studies that associated the practice of physical activity with counseling. However, the need for new studies on educational interventions among schoolchildren and adolescents was made evident.

Humanização da fisioterapia em Unidade de Terapia Intensiva Adulto: estudo transversal / Humanización de la fisioterapia en la unidad de cuidados intensivos adulta: estudio transversal / Humanization of physical therapy in an Intensive Care Unit for adults: a cross-sectional study

RESUMO Para promover qualidade de vida aos pacientes internados na unidade de terapia intensiva (UTI), há a necessidade e obrigação de humanizar o atendimento, em que somos comprometidos a prevenir, cuidar, proteger e recuperar, ou seja, promover saúde. O fisioterapeuta exerce um papel fundamental na reabilitação dos pacientes internados em UTI, e, além de qualidade técnica, deve prezar pela qualidade relacional de sua assistência, a fim de transmitir confiança e de estar atento às necessidades dos pacientes. O objetivo do estudo foi verificar se a assistência fisioterapêutica em unidade de terapia intensiva é realizada de forma humanizada. Trata-se de um estudo de corte transversal, mediante entrevistas com questionário avaliativo no quarto dos pacientes, incluindo 60 indivíduos maiores de 18 anos que receberam alta da UTI adulta. Os pacientes entrevistados aprovaram as condutas utilizadas pelos fisioterapeutas, destacando o cuidado destes ao realizar os procedimentos, a modo de evitar maior desconforto dos pacientes. Eles também apresentaram satisfação nas dimensões de atendimento, sendo que dignidade, comunicação, confiabilidade, aspectos interpessoais e receptividade alcançaram 100% de respostas positivas, garantia 98,3%, empatia 96,7%, os aspectos autonomia e eficácia emplacaram 95% das respostas favoráveis à humanização. Os pacientes demonstraram alto grau de aprazimento nos vários aspectos analisados quanto à assistência oferecida pelos fisioterapeutas, que devem prezar pela humanização em sua conduta profissional. Chegou-se à conclusão de que o atendimento fisioterapêutico disponibilizado na UTI foi caracterizado como humanizado pelos pacientes. Os fisioterapeutas demonstraram sua assistência com respeito e ética, possibilitando uma assistência de qualidade.

RESUMEN Para promocionar la calidad de vida a pacientes hospitalizados en unidades de cuidados intensivos (UCI), debe ser necesario humanizar la atención, en la que estamos comprometidos a prevenir, cuidar, proteger y recuperar, es decir, promocionar la salud. El fisioterapeuta es clave fundamental en la rehabilitación de pacientes hospitalizados en UCI, y además de calidad técnica debe apreciar la calidad relacional del cuidado, para tener confiabilidad y estar atento a lo que necesita el paciente. El propósito de este estudio es verificar si el cuidado fisioterapéutico en una unidad de cuidados intensivos es llevado a cabo de forma humanizada. Se trata de un estudio transversal, a través de entrevistas con cuestionario evaluativo en los cuartos de los pacientes, en lo cual fueron entrevistados 60 sujetos, con más de 18 años de edad y que tuvieron alta de la UCI adulta. Los entrevistados aprobaron la forma de trabajo de los fisioterapeutas, destacaron el cuidado que les tenían al realizar los procedimientos para que evitasen causarles más molestias. También estaban satisfechos en las dimensiones de atención, siendo que dignidad, comunicación, confiabilidad, aspectos interpersonales y receptividad llegaron a 100% de respuestas positivas, garantía 98,3%, empatía 96,7%, los aspectos autonomía y eficacia llegaron a 95% de las respuestas en pro de la humanización. Los pacientes mostraron alto grado de satisfacción en varios aspectos evaluados relativos al cuidado ofrecido por los fisioterapeutas, quienes deben apreciar la humanización en su práctica profesional. Se concluyó que el cuidado fisioterapéutico prestado en la UCI fue humanizado según la perspectiva de los pacientes. Los fisioterapeutas trabajaron con respeto y ética, lo que promueve la calidad del cuidado.

ABSTRACT To promote quality of life to intensive care unit (ICU) patients, treatments need and must be humanized, in that we are committed to preventing, caring, protecting, and recovering; that is, to promote health. Physical therapists play a fundamental role in the rehabilitation of ICU patients. Not only must they strive for technical quality but also for quality in the relationships involving the care they provide, in order to be viewed as reliable by patients and to be aware of their needs. The aim of this study was to verify whether the physical therapy care in an intensive care unit is conducted in a humanized way. This is a cross-sectional cohort study that used patient interviews via evaluation questionnaires and included 60 subjects over 18 years of age which had been discharged from the adult ICU. The interviewed patients approved the procedures carried out by the physical therapists and stressed their concern while conducting these procedures in way to keep their patients from experiencing discomfort. They were also satisfied with the treatment dimensions, with dignity, communication, reliability, interpersonal aspects, and receptivity reaching 100% of positive answers; assurance reaching 98.3%; empathy, 96.7%; and autonomy and effectiveness aspects, 95% of answers favoring humanization. The patients were shown to be satisfied, in the various aspects analyzed, with the care provided by the physical therapists, who must strive to carry out humanized professional practices. WE concluded that the physical therapy treatments the ICU patients received were characterized as humanized by them. The physical therapists demonstrated their concern with ethics, and this enabled good quality care.