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5.
J Clin Virol ; 31 Suppl 1: S3-6, 2004 Dec.
Article in English | MEDLINE | ID: mdl-15567088

ABSTRACT

BACKGROUND: Coinfection with hepatitis C virus (HCV) in individuals infected with HIV is associated with a higher incidence of liver injury, hepatic decompensation, and decreased survival time than that seen in an HIV-monoinfected population. While prevalence studies on HIV/HCV coinfection have been performed in the U.S. and in some European countries, little is known about coinfection rates in Africa. DESIGN: Retrospectively collected specimens from 146 confirmed HIV-positive individuals in Nigeria who had access to antiretroviral therapy (ART) were tested for HCV RNA, using the VERSANT HCV RNA qualitative assay (TMA), and, if HCV RNA-positive, for HCV genotype using the VERSANT HCV genotype assay (LiPA). RESULTS: Twelve out of the 146 individuals tested (8.2%) were HCV positive. Nine of the 12 HCV-positive individuals were infected with HCV genotype 1 (five 1a, three 1b, one non-subtypable) and three were infected with HCV genotype 2 (all non-subtypable). Coinfected individuals were more likely to be male, older, and have lower CD4+ cell counts than HIV-monoinfected individuals, although none of the differences reached statistical significance. CONCLUSION: The results highlight the potential public health impact of HCV infection in Nigeria, where anti-HCV testing is generally not performed in HIV-infected populations or in most blood transfusion centers.


Subject(s)
HIV Infections/complications , Hepacivirus/genetics , Hepatitis C/virology , RNA, Viral/analysis , Adult , CD4 Lymphocyte Count , Female , Genotype , HIV Infections/blood , HIV Infections/virology , HIV Seropositivity/immunology , Hepacivirus/isolation & purification , Hepatitis C/blood , Hepatitis C/complications , Humans , Male , Middle Aged , Nigeria/epidemiology , Prevalence , Retrospective Studies
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