ABSTRACT
In this Review we critically evaluate the empirical literature investigating the effect of paediatric brain tumours and their treatment on social affective function. We focus specifically on relations between social affective function and compromised brain structure and function associated with treatment for a paediatric brain tumour. We concentrate on emotion recognition and regulation, because these are core components of social affective function. First, we provide an overview of the literature in typically developing children and discuss the underlying brain networks thought to subserve emotion (ie, limbic system and supporting white matter microstructure). We then focus on how damage to brain structure and function after treatment for a paediatric brain tumour might be related to compromised emotion recognition and regulation-as well as broader social affective outcomes. On the basis of our review of the literature across typically developing children and those with a paediatric brain tumour, we suggest that structural changes to fronto-limbic tracts might interrupt social network neural communication in children and adolescents treated for brain tumours. A critical analysis of the reviewed literature suggests a relationship between social affective dysfunction and childhood-acquired injury to white matter microstructure. We argue that the knowledge synthesised regarding paediatric brain tumours could extend to other neurological disorders. Finally, we identify considerations for future investigation and recommend research practices to be adopted in forthcoming studies to establish causal links between brain structure and function to social affective processes.
Subject(s)
Brain Injuries , Brain Neoplasms , White Matter , Humans , Child , Adolescent , Brain , Brain Neoplasms/therapy , Brain Neoplasms/pathology , Emotions/physiology , White Matter/pathology , Brain Injuries/pathologyABSTRACT
Objective: Emotional problems such as anxiety and low mood have been associated with sleep problems in children. The study's objectives were to 1) assess the association between sleep duration and internalizing symptoms (anxiety and low mood) in children aged 5-12 years (y), and 2) evaluate whether insufficient sleep according to the National Sleep Foundation (NSF) guidelines is associated with internalizing symptoms. Methods: A cross-sectional study of N =796 children aged 5-12y, recruited from primary care physicians' offices in Toronto, Canada was conducted through the TARGet Kids! research network. Using linear regression, we investigated 1) the cross-sectional association between parent reported 24-hour sleep duration (hours) and parent reported symptoms using the Strengths and Difficulties Questionnaire (SDQ), controlling for child age, sex, family income, maternal education, family composition, and standardized body-mass index (zBMI). The analysis was repeated using insufficient sleep per NSF guideline as the independent variable. Results: Sleep duration was inversely associated with internalizing symptoms, B estimate = -0.33 (95%CI -0.57, -0.07), p=0.012. Twenty-eight (14%) children aged 5 y, and 36 (6%) of those aged 6-12y, experienced insufficient sleep. There was a trend toward association between insufficient sleep and internalizing symptoms, B estimate = 0.64 (-0.09, 1.38), p=0.086. Conclusion: The relationship between insufficient sleep and internalizing symptoms among children requires further elucidation. Children who show internalizing symptoms may benefit from interventions supporting sleep.
Objectif: Les problèmes émotionnels comme l'anxiété et l'humeur sombre ont été associés à des problèmes de sommeil chez les enfants. Les objectifs de la présente étude étaient de 1) évaluer l'association entre la durée du sommeil et les symptômes d'internalisation (anxiété et humeur sombre) chez les enfants de 5 à 12 ans (a), et 2) évaluer si le sommeil insuffisant selon les lignes directrices de la Fondation nationale du sommeil (FNS) est associé aux symptômes internalisants. Méthodes: Une étude transversale de N =796 enfants de 5 à 12 ans recrutés dans les bureaux de médecins de soins de première ligne à Toronto, Canada, a été menée dans le réseau de recherche TARGet Kids! À l'aide de la régression linéaire, nous avons investigué 1) l'association transversale entre la durée du sommeil (en heures) sur 24 heures rapportée par les parents et les symptômes rapportés par les parents à l'aide du questionnaire des forces et difficultés (QFD), en contrôlant pour l'âge de l'enfant, le sexe, le revenu familial, l'éducation maternelle, la composition de la famille et l'indice de masse corporelle normalisé (IMCn). L'analyse a été répétée avec le sommeil insuffisant selon les lignes directrices de la (FNS) comme variable indépendante. Résultats: La durée du sommeil était inversement associée à des symptômes d'internalisation, estimation B = −0,33 (IC à 95 % −0,57 à-0,07), p = 0,012. Vingt-huit (14 %) enfants âgés de 5 ans, et 36 (6 %) de ceux âgés de 6 à 12 ans avaient un sommeil insuffisant. Il y avait une tendance à l'association entre le sommeil insuffisant et les symptômes d'internalisation; estimation B = 0,64 (−0,09, 1,38), p = 0,086. Conclusion: La relation entre le sommeil insuffisant et les symptômes d'internalisation chez les enfants nécessite des éclaircissements. Les enfants souffrant de symptômes d'internalisation peuvent bénéficier d'interventions favorisant le sommeil.