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1.

Deep whole-genome ctDNA chronology of treatment-resistant prostate cancer.

Herberts, Cameron; Annala, Matti; Sipola, Joonatan; Ng, Sarah W S; Chen, Xinyi E; Nurminen, Anssi; Korhonen, Olga V; Munzur, Asli D; Beja, Kevin; Schönlau, Elena; Bernales, Cecily Q; Ritch, Elie; Bacon, Jack V W; Lack, Nathan A; Nykter, Matti; Aggarwal, Rahul; Small, Eric J; Gleave, Martin E; Quigley, David A; Feng, Felix Y; Chi, Kim N; Wyatt, Alexander W.

Nature ; 608(7921): 199-208, 2022 08.

Article in English | MEDLINE | ID: mdl-35859180

2.

Phase 1b study of enzalutamide plus CC-115, a dual mTORC1/2 and DNA-PK inhibitor, in men with metastatic castration-resistant prostate cancer (mCRPC).

Zhao, Jimmy L; Antonarakis, Emmanuel S; Cheng, Heather H; George, Daniel J; Aggarwal, Rahul; Riedel, Elyn; Sumiyoshi, Takayuki; Schonhoft, Joseph D; Anderson, Amanda; Mao, Ninghui; Haywood, Samuel; Decker, Brooke; Curley, Tracy; Abida, Wassim; Feng, Felix Y; Knudsen, Karen; Carver, Brett; Lacouture, Mario E; Wyatt, Alexander W; Rathkopf, Dana.

Br J Cancer ; 130(1): 53-62, 2024 01.

Article in English | MEDLINE | ID: mdl-37980367

3.

Androgen receptor genomic alterations and treatment resistance in metastatic prostate cancer.

Kwan, Edmond M; Wyatt, Alexander W.

Prostate ; 82 Suppl 1: S25-S36, 2022 08.

Article in English | MEDLINE | ID: mdl-35657159

4.

Genomic biomarkers to guide precision radiotherapy in prostate cancer.

Sutera, Philip; Deek, Matthew P; Van der Eecken, Kim; Wyatt, Alexander W; Kishan, Amar U; Molitoris, Jason K; Ferris, Matthew J; Siddiqui, M Minhaj; Rana, Zaker; Mishra, Mark V; Kwok, Young; Davicioni, Elai; Spratt, Daniel E; Ost, Piet; Feng, Felix Y; Tran, Phuoc T.

Prostate ; 82 Suppl 1: S73-S85, 2022 08.

Article in English | MEDLINE | ID: mdl-35657158

5.

TP53 Alterations Are Associated With Poor Survival in Patients With Primary Mediastinal Nonseminoma Germ Cell Tumors.

Bacon, Jack V W; Giannatempo, Patrizia; Cataldo, Giovanna; Fazli, Ladan; Saxena, Neetu; Ozgun, Guliz; Soleimani, Maryam; Chi, Kim; Nichols, Craig; Necchi, Andrea; Wyatt, Alexander W; Kollmannsberger, Christian K; Nappi, Lucia.

Oncologist ; 27(11): e912-e915, 2022 11 03.

Article in English | MEDLINE | ID: mdl-36166584

6.

Differential treatment outcomes in BRCA1/2-, CDK12-, and ATM-mutated metastatic castration-resistant prostate cancer.

Kwon, Daniel H; Chou, Jonathan; Yip, Steven M; Reimers, Melissa A; Zhang, Li; Wright, Francis; Dhawan, Mallika S; Borno, Hala T; Desai, Arpita; Aggarwal, Rahul R; Wyatt, Alexander W; Small, Eric J; Alva, Ajjai S; Chi, Kim N; Feng, Felix Y; Koshkin, Vadim S.

Cancer ; 127(12): 1965-1973, 2021 06 15.

Article in English | MEDLINE | ID: mdl-33690902

7.

Olaparib for the treatment of metastatic prostate cancer.

Dror, Corinne Maurice; Wyatt, Alexander W; Chi, Kim N.

Future Oncol ; 17(19): 2413-2429, 2021 Jul.

Article in English | MEDLINE | ID: mdl-33769071

8.

Optimal sequencing of enzalutamide and abiraterone acetate plus prednisone in metastatic castration-resistant prostate cancer: a multicentre, randomised, open-label, phase 2, crossover trial.

Khalaf, Daniel J; Annala, Matti; Taavitsainen, Sinja; Finch, Daygen L; Oja, Conrad; Vergidis, Joanna; Zulfiqar, Muhammad; Sunderland, Katherine; Azad, Arun A; Kollmannsberger, Christian K; Eigl, Bernhard J; Noonan, Krista; Wadhwa, Deepa; Attwell, Andrew; Keith, Bruce; Ellard, Susan L; Le, Lyly; Gleave, Martin E; Wyatt, Alexander W; Chi, Kim N.

Lancet Oncol ; 20(12): 1730-1739, 2019 12.

Article in English | MEDLINE | ID: mdl-31727538

9.

Characterization of transcriptomic signature of primary prostate cancer analogous to prostatic small cell neuroendocrine carcinoma.

Alshalalfa, Mohammed; Liu, Yang; Wyatt, Alexander W; Gibb, Ewan A; Tsai, Harrison K; Erho, Nicholas; Lehrer, Jonathan; Takhar, Mandeep; Ramnarine, Varune R; Collins, Colin C; Den, Robert B; Schaeffer, Edward M; Davicioni, Elai; Lotan, Tamara L; Bismar, Tarek A.

Int J Cancer ; 145(12): 3453-3461, 2019 12 15.

Article in English | MEDLINE | ID: mdl-31125117

10.

Biomarkers for Programmed Death-1 Inhibition in Prostate Cancer.

Manogue, Charlotte; Cotogno, Patrick; Ledet, Elisa; Lewis, Brian; Wyatt, Alexander W; Sartor, Oliver.

Oncologist ; 24(4): 444-448, 2019 04.

Article in English | MEDLINE | ID: mdl-30541755

11.

DNA repair defects in prostate cancer: impact for screening, prognostication and treatment.

Warner, Evan W; Yip, Steven M; Chi, Kim N; Wyatt, Alexander W.

BJU Int ; 123(5): 769-776, 2019 05.

Article in English | MEDLINE | ID: mdl-30281887

12.

Biallelic tumour suppressor loss and DNA repair defects in de novo small-cell prostate carcinoma.

Chedgy, Edmund Cp; Vandekerkhove, Gillian; Herberts, Cameron; Annala, Matti; Donoghue, Adam J; Sigouros, Michael; Ritch, Elie; Struss, Werner; Konomura, Saki; Liew, Janet; Parimi, Sunil; Vergidis, Joanna; Hurtado-Coll, Antonio; Sboner, Andrea; Fazli, Ladan; Beltran, Himisha; Chi, Kim N; Wyatt, Alexander W.

J Pathol ; 246(2): 244-253, 2018 10.

Article in English | MEDLINE | ID: mdl-30015382

13.

SiNVICT: ultra-sensitive detection of single nucleotide variants and indels in circulating tumour DNA.

Kockan, Can; Hach, Faraz; Sarrafi, Iman; Bell, Robert H; McConeghy, Brian; Beja, Kevin; Haegert, Anne; Wyatt, Alexander W; Volik, Stanislav V; Chi, Kim N; Collins, Colin C; Sahinalp, S Cenk.

Bioinformatics ; 33(1): 26-34, 2017 01 01.

Article in English | MEDLINE | ID: mdl-27531099

14.

DNA Repair Gene Alterations and PARP Inhibitor Response in Patients With Metastatic Castration-Resistant Prostate Cancer.

Lu, Eric; Thomas, George V; Chen, Yiyi; Wyatt, Alexander W; Lloyd, Paul; Youngren, Jack; Quigley, David; Bergan, Raymond; Bailey, Shawna; Beer, Tomasz M; Feng, Felix Y; Small, Eric J; Alumkal, Joshi J.

J Natl Compr Canc Netw ; 16(8): 933-937, 2018 08.

Article in English | MEDLINE | ID: mdl-30099369

15.

Circulating Tumor Cells (CTC) and Cell-Free DNA (cfDNA) Workshop 2016: Scientific Opportunities and Logistics for Cancer Clinical Trial Incorporation.

Lowes, Lori E; Bratman, Scott V; Dittamore, Ryan; Done, Susan; Kelley, Shana O; Mai, Sabine; Morin, Ryan D; Wyatt, Alexander W; Allan, Alison L.

Int J Mol Sci ; 17(9)2016 Sep 08.

Article in English | MEDLINE | ID: mdl-27618023

16.

nFuse: discovery of complex genomic rearrangements in cancer using high-throughput sequencing.

McPherson, Andrew; Wu, Chunxiao; Wyatt, Alexander W; Shah, Sohrab; Collins, Colin; Sahinalp, S Cenk.

Genome Res ; 22(11): 2250-61, 2012 Nov.

Article in English | MEDLINE | ID: mdl-22745232

17.

ShatterProof: operational detection and quantification of chromothripsis.

Govind, Shaylan K; Zia, Amin; Hennings-Yeomans, Pablo H; Watson, John D; Fraser, Michael; Anghel, Catalina; Wyatt, Alexander W; van der Kwast, Theodorus; Collins, Colin C; McPherson, John D; Bristow, Robert G; Boutros, Paul C.

BMC Bioinformatics ; 15: 78, 2014 Mar 19.

Article in English | MEDLINE | ID: mdl-24646301

18.

Molecular landscape of carcinoma invading bladder muscle: does patient age matter?

Seiler, Roland; Wyatt, Alexander W; Black, Peter C.

BJU Int ; 124(5): 719-721, 2019 11.

Article in English | MEDLINE | ID: mdl-31074172

19.

In Brief: Chromothripsis and cancer.

Wyatt, Alexander W; Collins, Colin C.

J Pathol ; 231(1): 1-3, 2013 Sep.

Article in English | MEDLINE | ID: mdl-23744564

20.

Toward Informed Selection and Interpretation of Clinical Genomic Tests in Prostate Cancer.

Vandekerkhove, Gillian; Giri, Veda N; Halabi, Susan; McNair, Christopher; Hamade, Khaldoun; Bitting, Rhonda L; Wyatt, Alexander W.

JCO Precis Oncol ; 8: e2300654, 2024 Mar.

Article in English | MEDLINE | ID: mdl-38547422

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