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1.
Mol Psychiatry ; 16(2): 202-15, 2011 Feb.
Article in English | MEDLINE | ID: mdl-20038947

ABSTRACT

We report a genome-wide association study (GWAS) of major depressive disorder (MDD) in 1221 cases from the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study and 1636 screened controls. No genome-wide evidence for association was detected. We also carried out a meta-analysis of three European-ancestry MDD GWAS data sets: STAR*D, Genetics of Recurrent Early-onset Depression and the publicly available Genetic Association Information Network-MDD data set. These data sets, totaling 3957 cases and 3428 controls, were genotyped using four different platforms (Affymetrix 6.0, 5.0 and 500 K, and Perlegen). For each of 2.4 million HapMap II single-nucleotide polymorphisms (SNPs), using genotyped data where available and imputed data otherwise, single-SNP association tests were carried out in each sample with correction for ancestry-informative principal components. The strongest evidence for association in the meta-analysis was observed for intronic SNPs in ATP6V1B2 (P=6.78 x 10⁻7), SP4 (P=7.68 x 10⁻7) and GRM7 (P=1.11 x 10⁻6). Additional exploratory analyses were carried out for a narrower phenotype (recurrent MDD with onset before age 31, N=2191 cases), and separately for males and females. Several of the best findings were supported primarily by evidence from narrow cases or from either males or females. On the basis of previous biological evidence, we consider GRM7 a strong MDD candidate gene. Larger samples will be required to determine whether any common SNPs are significantly associated with MDD.


Subject(s)
Depressive Disorder, Major/genetics , Genome-Wide Association Study , Adolescent , Adult , Age of Onset , Aged , Europe , Female , Gene Expression Profiling/methods , Genotype , Humans , Male , Meta-Analysis as Topic , Middle Aged , Oligonucleotide Array Sequence Analysis/methods , Polymorphism, Single Nucleotide/genetics , Principal Component Analysis , Receptors, Metabotropic Glutamate/genetics , Sp4 Transcription Factor/genetics , Vacuolar Proton-Translocating ATPases/genetics , Young Adult
2.
J. bras. nefrol ; 6(2): 39-41, 1984.
Article in Portuguese | LILACS | ID: lil-21784

ABSTRACT

Dentre 114 pacientes submetidos a transplante renal, os autores observaram a ocorrencia de disfuncao renal pos-operatoria do tipo necrose tubular aguda em 16% dos receptores de rim de doador vivo aparentado e em 50% dos casos em que o doador era descerebrado. A hemodialise pos-operatoria, 3 vezes por semana, com heparinizacao continua na dose de 10 unidades/ kg/hora, nao aumentou a morbidade, enquanto permitiu aguardar-se a recuperacao de diurese adequada, de sorte que a funcao renal, medida pela creatinina plasmatica, estava igual a do grupo sem insuficiencia renal, exceto nos poucos casos de necrose tubular aguda observados quando o doador era vivo e aparentado. Ao final do primeiro ano de observacao houve maior perda renal por agressao imunologica irreversivel naqueles pacientes que tiveram insuficiencia renal aguda


Subject(s)
Child , Adolescent , Adult , Middle Aged , Humans , Male , Female , Acute Kidney Injury , Kidney , Transplantation
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