The effect of mood on shaping belief and recollection following false feedback.

The current study examined how mood affects the impact of false feedback on belief and recollection. In a three-session experiment, participants first watched 40 neutral mini videos, which were accompanied by music to induce either a positive or negative mood, or no music. Following a recognition test, they received false feedback to reduce belief in the occurrence of the events displayed in some of the videos (Session 2). This was followed by an immediate memory test and a delayed memory assessment one week later (Session 3). The results revealed that participants in negative mood reported higher belief scores compared to those in positive moods, despite an overall decline in belief scores for all groups following the false feedback. Notably, individuals in negative moods exhibited less reduction in their belief scores after encountering challenges, thereby maintaining a higher accuracy in their testimonies. Over time, a reduction in the clarity of participants' memory recall was observed, which correspondingly reduced their testimony accuracy. This study thus indicates that mood states play a role in shaping belief and memory recall under the influence of false feedback.

Inducing emotionally negative nonbelieved memories using negative pictures.

Memories that can be recalled but are no longer believed are termed nonbelieved memories. The current studies examined the creation of emotionally negative nonbelieved memories after viewing negatively valenced pictures. In both experiments, participants took part in two sessions. In Session 1, after being presented with a set of neutral and negative pictures, participants had to rate their emotional state. One week later, in Session 2, participants had to complete a recognition task to identify pictures that had appeared during the previous session. During this task, participants' memories for some pictures were challenged by telling them that their answers were incorrect in order to evoke nonbelieved memories. The experimental procedure was successful in creating nonbelieved memories in the participants. Specifically, in Experiment 1 (N = 35), we induced nonbelieved true memories for both negative and neutral pictures. We found a significant decrease in both belief and recollection after the challenge, with the change in belief being twice as large as the change in recollection. In Experiment 2 (N = 43), we successfully induced both nonbelieved true and false memories for negative pictures. Again, the reduction of belief was significantly greater than that of recollection. In general, participants evinced better memory for negative pictures, but following challenges people were just as likely to accept false social feedback and change their memories regarding other types of pictures. In both experiments, our challenges did not lead to notable changes in emotional state. In general, our findings show that emotionally negative nonbelieved memories can be successfully evoked in an experimental setting.

Time and memory distrust shape the dynamics of recollection and belief-in-occurrence.

The current study examined how people's metamemory judgments of recollection and belief-in-occurrence change over time. Furthermore, we examined to what extent these judgments are affected by memory distrust - the subjective appraisal of one's memory functioning - as measured by the Memory Distrust Scale (MDS) and the Squire Subjective Memory Scale (SSMQ). Participants (N = 234) studied pictorial stimuli and were tested on some of these stimuli later in the same session, but were tested on other stimuli 1, 2, 4, 8, and 17 days later. Recollection and belief ratings were correlated highly and followed similar declining patterns over time. However, belief decreased relatively more slowly than recollection, such that the discrepancy between recollection and belief increased over time. Memory distrust moderated the association between recollection and belief, with this association being weaker among people who reported greater (versus lower) memory distrust. Memory distrust also interacted with retention period to predict memory judgments. Two measures of memory distrust diverged in their predictive power. In particular, only the MDS predicted the spontaneous reporting of nonbelieved memories. Our results provide support to the theoretical perspective that belief-in-occurrence is a summative judgment informed not only by recollective phenomenology but also by metamemorial beliefs.

Exposure Order to Photoaging and Humic Acids Significantly Modifies the Aggregation and Transformation of Nanoplastics in Aqueous Solutions.

The colloidal stability of nanoplastics in aqueous solutions is greatly regulated by photoaging and dissolved organic matter (DOM). However, how the exposure order to sunlight and DOM modifies the environmental behavior of nanoplastics is seldomly determined. Here, with two different exposure orders, we investigated the impact of molecular-weight (MW)-fractionated humic acids (HAs) derived from biochar and the Suwannee River, respectively, on the aggregation of poly(ethylene terephthalate) nanoplastics (PET-NPs) in mono- and divalent electrolyte solutions. For exposure pattern (i) (photoaging followed by HA coating), photoaged PET-NPs had more oxidized surfaces and exhibited 22-320% higher binding affinity to HAs (especially the higher MW fractions) than the pristine counterparts, which greatly improved the dispersion of PET-NPs. For exposure pattern (ii) (HA coating followed by photoaging), HA-PET assemblies were formed, the dispersion of which increased with increasing irradiation time and was significantly higher than that of the samples in the exposure pattern (i) at the end of the experiment. This high dispersion of photoaged HA-PET assemblies was ascribed to the extra oxidation of PET by reactive oxygen species generated in the PET-HA interfaces during photoaging. These findings highlight the "active nature" of HA-PET assemblies, which provide new insight into the reaction of HA with nanoplastics beyond adsorption in the natural environment.

Preference for cheap-and-easy memory verification strategies is strongest among people with high memory distrust.

When choosing strategies for verifying one's memory, people are more influenced by the perceived cost of using a strategy than by its likelihood of yielding reliable information (i.e., cheap-strategy bias). The current preregistered study investigated whether people with high memory distrust are less likely to exhibit this bias than their low memory distrust counterparts. Participants (N = 535) imagined a scenario in which they witnessed an accident and were then led by friends to question their memories about the accident. Participants had to propose five strategies for verifying that particular memory. Following this, they rated each strategy's cost, reliability, and their likelihood of using it, as well as completing two validated measures of trait memory distrust. Contrary to our prediction, compared with participants with low memory distrust, participants with higher memory distrust exhibited a larger cheap-strategy bias. Follow-up analyses suggested that compared with memory-trusters, memory distrusters' strategy choices were more influenced by a strategy's perceived cost, and less influenced by its perceived reliability. Our results suggest that people who are more skeptical about their memories may be more cynical about the worthwhileness of verifying their memory, which could make them especially susceptible to misinformation acceptance and false memory creation.

Criticality and Phase Classification for Quadratic Open Quantum Many-Body Systems.

We study the steady states of translation-invariant open quantum many-body systems governed by Lindblad master equations, where the Hamiltonian is quadratic in the ladder operators, and the Lindblad operators are either linear or quadratic and Hermitian. These systems are called quasifree and quadratic, respectively. We find that steady states of one-dimensional systems with finite-range interactions necessarily have exponentially decaying Green's functions. For the quasifree case without quadratic Lindblad operators, we show that fermionic systems with finite-range interactions are noncritical for any number of spatial dimensions and provide bounds on the correlation lengths. Quasifree bosonic systems can be critical in D>1 dimensions. Last, we address the question of phase transitions in quadratic systems and find that, without symmetry constraints beyond invariance under single-particle basis and particle-hole transformations, all gapped Liouvillians belong to the same phase.

Photochemical Transformation and Catalytic Activity of Dissolved Black Nitrogen Released from Environmental Black Carbon.

Biomass combustion results in the formation and wide distribution of black carbon (BC) in soils, wherein the dissolved fractions are among the most active components. Although the presence of dissolved black nitrogen (DBN) in BC has been identified, its environmental behavior and implication are not understood. This study investigated the photochemical transformation and catalytic activity of DBN under simulated solar irradiation. DBN is more easily transformed than dissolved BC due to its photoactive heteroaromatic N structure, and the half-life of DBN produced at 500 °C (8.6 h) is two times shorter than that of the dissolved BC counterpart (23 h). Meanwhile, solar irradiation is favorable for the homoaggregation of DBN. During irradiation, DBN generates not only reactive oxygen species (e.g., 1O2, O2-, and •OH) but also reactive nitrogen species (mainly •ON), which account for its higher photocatalytic degradation of bisphenol A than dissolved BC. These findings shed new light on the impact of heteroatoms on the phototransformation and activity of BC as well as cycling of N in terrestrial systems.

Azepine- or Azocine-Embedded Hexabenzocoronene Derivatives as Nitrogen-Doped Saddle or Saddle-Helix Nanographenes.

Two novel nitrogen-doped, hexa-peri-hexabenzocoronene (HBC)-based nanographenes (NGs) 1 and 2 bearing an azepine and an azocine at the fjord region, respectively, were synthesized and characterized. Notably, structure 1 was synthesized by Diels-Alder reaction of cyclic alkene and tetrachlorothiophene-S,S-dioxide, followed by Suzuki-Miyaura cross-coupling and Scholl-type reactions, which represents a modified strategy to construct NGs. The azo-heptagon-embedded NG 1 leads to a saddle shape, and the azo-octagon-embedded NG 2 exhibits a distorted saddle-helix conformation with the largest torsion angle recorded so far in [5]helicenes. As a result, the different structural topographies for NGs 1 and 2 lead to significant changes in the optical properties including UV absorption and fluorescent emission. Additionally, the 8π-heterocycles azepine and azocine in the NGs 1 and 2 exhibited obvious antiaromatic properties.

Excess entropy and long-time diffusion in colloidal fluids with short-range interparticle attraction.

Liquid structure and dynamics are experimentally investigated in colloidal suspensions with short-range depletion attraction. The colloidal fluid samples consist of hard-sphere colloidal particles suspended along with rodlike depletants based on surfactant micelles. The spheres have a range of surface chemistries, diameters, and packing fractions, and the rodlike micelle length depends on the temperature. Thus, the combination of hard-spheres and depletants generates a sample wherein short-range interparticle attraction can be temperature-tuned in situ. Video optical microscopy and particle tracking techniques are employed to measure particle trajectories from which structural and dynamical quantities are derived, including the particle pair correlation function [g(r)], mean square displacement, long-time diffusion coefficient, and the sample two-body excess entropy (S2). The samples with stronger short-range attractions exhibit more order, as characterized by g(r) and S2. The stronger short-range attractions are also observed to lead to slower long-time diffusion and more heterogeneous dynamics at intermediate time scales. Finally, the excess entropy scaling law prediction, i.e., the exponential relationship between two-body excess entropy and long-time diffusivity, is observed across the full range of samples.

A 2-week high-intensity interval training intervention improves ejaculation control among men with premature ejaculation.

BACKGROUND: Premature ejaculation (PE), which leads to substantial distress in men and their partners, is a common male sexual dysfunction worldwide. However, there is still a lack of effective treatments without side effects. OBJECTIVES: We investigated the effect of high-intensity interval training (HIIT) on PE symptoms. MATERIALS AND METHODS: We recruited 92 Chinese men aged 18-36 to complete the experiment. There were 22 (13 in the control group; 9 in the HIIT group) men diagnosed with PE and 70 (41 in the control group; 29 in the HIIT group) men with normal ejaculatory function. In the HIIT group, participants completed HIIT exercises every morning for 14 days. Participants also completed surveys inquiring about demographic information, erectile function, PE symptoms, body image (including sexual body image), physical activity, and sexual desire. The heart rate was measured before and after each HIIT. In the control group, participants were instructed not to do HIIT, but other procedures were the same as in the HIIT group. RESULTS: Results indicated that the HIIT intervention alleviated PE symptoms in men with PE. In addition, in the HIIT group, men with PE who had a higher heart-rate increase during the HIIT intervention reported the greatest overall decrements in PE symptoms. In men with normal ejaculatory function, HIIT did not decrease PE symptoms. In addition, increments in the heart rate during the intervention were associated with more pronounced PE symptoms post-intervention in this group. Analyses of secondary outcome measures suggested that the HIIT intervention improved general and sexual body image satisfaction of men with PE compared to before the intervention. DISCUSSION AND CONCLUSION: In summary, HIIT intervention may reduce PE symptoms in men with PE. The heart-rate increase during the intervention may be a key factor influencing the effect of the HIIT intervention on PE symptoms.

Bidirectional relationship between sexual arousal and (sex-related) disgust.

Sexual stimuli provoke both sexual arousal and disgust, and the coaction between these emotions determines sexually behavioral outcomes. The current research includes two experiments to explore the bidirectional relationship between sexual arousal toward erotic stimuli and disgust induced by sexual body fluids. Study 1 presented 234 participants (117 women) with sexual body (vs. neutral) fluids followed by erotic stimuli, and Study 2 presented 235 participants (117 women) with erotic (vs. neutral) videos followed by sexual body fluids (and a non-sex-related stimulus). Study 1 showed that exposure to sexual body fluids reduced sexual arousal and the likelihood of sexual engagement toward erotic stimuli in participants with high sexual disgust sensitivity but increased sexual arousal and the likelihood of sexual engagement in participants with low sexual disgust sensitivity, while Study 2 suggested that men exposed to erotic (vs. neutral) stimuli reported lower disgust, stronger sexual arousal state, and higher willingness to interact with the sexual body fluids. There was no relationship between subjective feelings of sexual arousal and disgust in these experiments, while the balance of sexual arousal and disgust toward sexual body fluids and erotic stimuli had a positive association. Also, exposure to erotic stimuli had no effect on reactions to generally disgusting stimulus, but feelings of sexual arousal toward erotic stimuli were positively associated with disgust induced by generally disgusting fluid. These findings suggest that Behavior Immune System regulates disgust to establish a balance between benefit and cost related to sex as well as provide insight into the process underlying sexual dysfunctions.

Effects of Ginger on Disgust, Sexual Arousal, and Sexual Engagement: A Placebo-Controlled Experiment.

Sexual problems are common complaints across countries and cultures, and behavioral immune system theory suggests disgust plays an essential role in sexual functioning. The current study investigated 1) if disgust induced by sexual body fluids would reduce sexual arousal, reduce the likelihood of sexual engagement, and enhance disgust toward subsequent erotic stimuli, and 2) if the administration of ginger would affect these reactions. We administered either ginger or placebo pills to a sample of 247 participants (Mage = 21.59, SD = 2.52; 122 women) and asked them to complete either behavioral approach tasks with sexual body fluids or with neutral fluids. Next, participants viewed and responded to questions concerning erotic stimuli (nude and seminude pictures of opposite-sex models). As expected, the sexual body fluids tasks induced disgust. The elevated disgust induced by sexual body fluids tasks resulted in lower sexual arousal in women, whereas ginger consumption counteracted this inhibiting effect of disgust on sexual arousal. Disgust elicited by sexual body fluids also increased disgust toward the subsequent erotic stimuli. Ginger increased sexual arousal toward the erotic stimuli in both men and women who had completed the neutral fluids tasks. Findings provide further evidence of the role of disgust in sexual problems, and, importantly, that ginger may improve the sexual function of individuals via its sexual arousal-enhancing effect.

Effects of combining feedback and hypothesis-testing on the quality of simulated child sexual abuse interviews with avatars among Chinese university students.

Previous research has shown that simulation training using avatars with repeated feedback improves child sexual abuse interview quality. The present study added a hypothesis-testing intervention and examined if the combination of two interventions, feedback and hypothesis-testing, would improve interview quality compared to no intervention and to either intervention alone. Eighty-one Chinese university students were randomly assigned to a control, feedback, hypothesis-testing, or the combination of feedback and hypothesis-testing group and conducted five simulated child sexual abuse interviews online. Depending on the assigned group, feedback on the outcome of the cases and question types used in the interview were provided after each interview, and/or the participants built hypotheses based on preliminary case information before each interview. The combined interventions group and feedback group showed a higher proportion of recommended questions and correct details from the 3rd interview onward compared to the hypothesis-building and control groups. The difference between the number of correct conclusions was not significant. hypothesis-testing alone exacerbated the use of non-recommended questions over time. The results show that hypothesis-testing may impact question types used negatively but not when combined with feedback. The potential reasons for hypothesis-testing alone not being effective and the differences between the present and previous studies were discussed.

Azepine-Embedded Seco-Hexabenzocoronene-Based Helix Nanographenes: Access to Modification of the Core by N-H Functionalization.

Contorted polycyclic aromatic hydrocarbons (PAHs) or nanographenes (NGs) have received increasing attention and are mostly prepared by "bottom-up" strategies. Apparently, systematically tuning the properties of NGs for application is important but challenging. Here, a new type of helix, azepine-embedded NGs, were designed and synthesized by the introduction of NH into the hexa-peri-hexabenzocoronene (HBC) core. We demonstrate that this nitrogen-doped NG can be functionalized via N-H derivatization. Through modifications to the NH site with a chiral auxiliary reagent, optical resolution of the chiral NG was achieved. Meanwhile, it was found that by introducing various aryl groups with electron-donating or electron-withdrawing substituents, the emission intensity and the fluorescence mechanism can be modulated. Compared to the original NH-containing NG, the modified derivative exhibited improved fluorescence efficiency and tunable emission wavelength. A functionalized structure of benzoic acid with considerably improved fluorescence efficiency, hydrophilicity, and membrane permeability to stain the live cells was proved.

BINOL-like atropisomeric chiral nanographene.

Interest in making chiral polycyclic aromatic hydrocarbons (PAHs) or nanographenes (NGs) has greatly increased recently. To date, a majority of chiral nanocarbons have been designed based on helical chirality. Here, we describe a novel atropisomeric chiral oxa-NG 1 by the selective dimerization of naphthalene-containing, hexa-peri-hexabenzocoronene (HBC)-based PAH 6. The photophysical properties of the oxa-NG 1 and monomer 6 were investigated, including UV-vis absorption (λ max = 358 nm for 1 and 6), fluorescence emission (λ em = 475 nm for 1 and 6), fluorescence decay (15 vs. 16 ns), and fluorescence quantum yield, and it was found that the photophysical properties of the monomer are nearly maintained in the NG dimer due to its perpendicular conformation. Single-crystal X-ray diffraction analysis shows that both enantiomers cocrystallize in a single crystal, and the racemic mixture can be resolved by chiral high-performance liquid chromatography (HPLC). The circular dichroism (CD) spectra and circularly polarized luminescence (CPL) of the enantiomers of 1-S and 1-R were studied and the CD and CPL spectra exhibited opposite Cotton effects and fluorescence signals. Density functional theory (DFT) calculations and HPLC-based thermal isomerization results showed that the racemic barrier is as high as 35 kcal mol-1, suggesting a rigid chiral nanographene structure. Meanwhile, in vitro studies indicated that oxa-NG 1 is an efficient photosensitizer for white-light-induced singlet oxygen generation.

Associations between emotions and psychophysiological states and confirmation bias in question formulation in ongoing simulated investigative interviews of child sexual abuse.

Introduction: In forensic settings interviewers are advised to ask as many open-ended questions as possible. However, even experts may have difficulty following this advice potentially negatively impacting an investigation. Here, we sought to investigate how emotions and psychophysiological parameters are associated with question formulation in real time in an ongoing (simulated) child sexual abuse (CSA) interview. Method: In a experimental study, psychology students (N = 60, Mage = 22.75) conducted two interviews with child avatars, while their emotions (anger, sadness, disgust, surprise and relief), GSR and heart rate (HR) were registered. Results: First, we found that general emotionality related to CSA and perceived realness of the avatars was associated with stronger overall emotional reactions. Second, we found that closed (vs. open) questions were preceded by more facially observable anger, but not disgust, sadness, surprise or relief. Third, closed (vs. open) questions were preceded by higher GSR resistance and lower heart rate. Discussion: Results suggest for the first time that emotions and psychophysiological states can drive confirmation bias in question formulation in real time in CSA.

A tetrazole-ene photoactivatable fluorophore with improved brightness and stability in protic solution.

The pyrazoline fluorophore, generated by photoinduced tetrazole-ene cycloaddition, shows faint fluorescence in protic solvents. To suppress this fluorescence-quenching, we rationally designed a series of substituted diaryl tetrazoles at the N-side phenyl ring to produce a tetrazole-ene based photoactivatable fluorophore. Spectroscopic and cellular imaging studies demonstrated that the version of the fluorophore with a bis(trifluoromethyl)benzene substituent exhibited significantly enhanced brightness and photostability.

SemanticCAP: Chromatin Accessibility Prediction Enhanced by Features Learning from a Language Model.

A large number of inorganic and organic compounds are able to bind DNA and form complexes, among which drug-related molecules are important. Chromatin accessibility changes not only directly affect drug-DNA interactions, but they can promote or inhibit the expression of the critical genes associated with drug resistance by affecting the DNA binding capacity of TFs and transcriptional regulators. However, the biological experimental techniques for measuring it are expensive and time-consuming. In recent years, several kinds of computational methods have been proposed to identify accessible regions of the genome. Existing computational models mostly ignore the contextual information provided by the bases in gene sequences. To address these issues, we proposed a new solution called SemanticCAP. It introduces a gene language model that models the context of gene sequences and is thus able to provide an effective representation of a certain site in a gene sequence. Basically, we merged the features provided by the gene language model into our chromatin accessibility model. During the process, we designed methods called SFA and SFC to make feature fusion smoother. Compared to DeepSEA, gkm-SVM, and k-mer using public benchmarks, our model proved to have better performance, showing a 1.25% maximum improvement in auROC and a 2.41% maximum improvement in auPRC.

Photoactivatable Fluorogenic Azide-Alkyne Click Reaction: A Dual-Activation Fluorescent Probe.

Aryl azide and diaryl tetrazole are both photoactive molecules, which can form nitrene and nitrile imine intermediates respectively by photolysis. Depending on the new finding that the azide can suppress the photolysis of tetrazole in the azide-tetrazole conjugated system, we developed aryl azide-tetrazole probes for the photoactivatable fluorogenic azide alkyne click (PFAAC) reaction, in which the aryl azide-tetrazole probes were not phoroactivatable fluorogenic itself, but the triazole products after click reaction were prefluorophore that can be activated by light. Therefore, in PFAAC chemistry, the fluorescent probes can be activated by two orthogonal events: azide-alkyne click reaction and light, which leads to spatiotemporal resolution and high signal-to-noise ratio. This PFAAC process was proved in vitro by copper-catalyzed or strain-promoted azide-alkyne reactions and in live cells by spatiotemporally controlled organelle imaging. By incorporation a linker to the azide-tetrazole conjugate, this PFAAC chemistry could covalently label extra probes to the biomolecules and spatiotemporally detecting this process by photoinduced fluorescence.

Azepine- or Oxepine-embedded Double Saddle-Helix Nanographenes.

The azepine- and oxepine-embedded polycyclic aromatic hydrocarbons (PAH) 1-3, as the hexa-peri-hexabenzocoronene (HBC)-based nanographenes (NG) were designed and synthesized by Diels-Alder reaction of cyclic alkene with tetrachlorothiophene-S,S-dioxide, followed by Suzuki-Miyaura cross-coupling and Scholl-type cyclodehydrogenation. Due to the strained seven-membered ring and the inherent structural pattern, heteroatom-doped NGs 1-3 show Cs symmetrical, double saddle-helix hybrid conformation, which represents a new shape for HBC based nanographenes. The calculation studies reveal the low aromaticity of the 8π heterocycles themselves and the heterocycles also decrease the electron delocalization of benzenes surrounding them. Dynamics-based calculation suggests the Cs symmetry would maintain druing the saddle-inversion process. Meanwhile, we show property perturbation by doping with different heteroatoms.