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Bioorg Med Chem Lett
; 19(3): 697-700, 2009 Feb 01.
Article
in English
| MEDLINE
| ID: mdl-19112018
ABSTRACT
3-amido-4-anilinoquinolines are potent and highly selective inhibitors of CSF-1R. Their synthesis and SAR is reported, along with initial efforts to optimize the physical properties and PK through modifications at the quinoline 6- and 7-positions.