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1.
Potent and sustained huntingtin lowering via AAV5 encoding miRNA preserves striatal volume and cognitive function in a humanized mouse model of Huntington disease.
Nucleic Acids Res
; 48(1): 36-54, 2020 01 10.
Article
in English
| MEDLINE | ID: mdl-31745548
2.
25 years of anti-TNF treatment for inflammatory bowel disease: lessons from the past and a look to the future.
Gut
; 70(7): 1396-1405, 2021 07.
Article
in English
| MEDLINE | ID: mdl-33431575
3.
AAV5-miHTT Gene Therapy Demonstrates Broad Distribution and Strong Human Mutant Huntingtin Lowering in a Huntington's Disease Minipig Model.
Mol Ther
; 26(9): 2163-2177, 2018 09 05.
Article
in English
| MEDLINE | ID: mdl-30007561
4.
Cholesterol ester transfer protein inhibition by TA-8995 in patients with mild dyslipidaemia (TULIP): a randomised, double-blind, placebo-controlled phase 2 trial.
Lancet
; 386(9992): 452-60, 2015 Aug 01.
Article
in English
| MEDLINE | ID: mdl-26047975
5.
Tolerability, pharmacokinetics and pharmacodynamics of TA-8995, a selective cholesteryl ester transfer protein (CETP) inhibitor, in healthy subjects.
Br J Clin Pharmacol
; 78(3): 498-508, 2014 Sep.
Article
in English
| MEDLINE | ID: mdl-24628035
6.
Embedding siRNA sequences targeting apolipoprotein B100 in shRNA and miRNA scaffolds results in differential processing and in vivo efficacy.
Mol Ther
; 21(1): 217-27, 2013 Jan.
Article
in English
| MEDLINE | ID: mdl-23089734
7.
Mir-142-3p target sequences reduce transgene-directed immunogenicity following intramuscular adeno-associated virus 1 vector-mediated gene delivery.
J Gene Med
; 15(6-7): 219-32, 2013.
Article
in English
| MEDLINE | ID: mdl-23658149
8.
Adenosine triphosphate-binding cassette transporter genes up-regulation in untreated hepatocellular carcinoma is mediated by cellular microRNAs.
Hepatology
; 55(3): 821-32, 2012 Mar.
Article
in English
| MEDLINE | ID: mdl-21932399
9.
Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation.
Nat Genet
; 36(3): 277-82, 2004 Mar.
Article
in English
| MEDLINE | ID: mdl-14770182
10.
Optimization and comparison of knockdown efficacy between polymerase II expressed shRNA and artificial miRNA targeting luciferase and Apolipoprotein B100.
BMC Biotechnol
; 12: 42, 2012 Jul 24.
Article
in English
| MEDLINE | ID: mdl-22827812
11.
Molecular therapy for obesity and diabetes based on a long-term increase in hepatic fatty-acid oxidation.
Hepatology
; 53(3): 821-32, 2011 Mar.
Article
in English
| MEDLINE | ID: mdl-21319201
12.
Murine CD4âºCD25â» cells activated in vitro with PMA/ionomycin and anti-CD3 acquire regulatory function and ameliorate experimental colitis in vivo.
BMC Gastroenterol
; 12: 172, 2012 Dec 03.
Article
in English
| MEDLINE | ID: mdl-23198878
13.
Apolipoprotein B knockdown by AAV-delivered shRNA lowers plasma cholesterol in mice.
Mol Ther
; 19(4): 731-40, 2011 Apr.
Article
in English
| MEDLINE | ID: mdl-21304496
14.
Induction of antigen-specific tolerance by oral administration of Lactococcus lactis delivered immunodominant DQ8-restricted gliadin peptide in sensitized nonobese diabetic Abo Dq8 transgenic mice.
J Immunol
; 183(4): 2390-6, 2009 Aug 15.
Article
in English
| MEDLINE | ID: mdl-19635921
15.
Secreted therapeutics: monitoring durability of microRNA-based gene therapies in the central nervous system.
Brain Commun
; 3(2): fcab054, 2021.
Article
in English
| MEDLINE | ID: mdl-34704020
16.
Longitudinal Assessment of Lipoprotein(a) Levels in Perinatally HIV-Infected Children and Adolescents.
Viruses
; 13(10)2021 10 14.
Article
in English
| MEDLINE | ID: mdl-34696496
17.
PhP.B Enhanced Adeno-Associated Virus Mediated-Expression Following Systemic Delivery or Direct Brain Administration.
Front Bioeng Biotechnol
; 9: 679483, 2021.
Article
in English
| MEDLINE | ID: mdl-34414171
18.
Widespread and sustained target engagement in Huntington's disease minipigs upon intrastriatal microRNA-based gene therapy.
Sci Transl Med
; 13(588)2021 04 07.
Article
in English
| MEDLINE | ID: mdl-33827977
19.
Cerebral Organoids: A Human Model for AAV Capsid Selection and Therapeutic Transgene Efficacy in the Brain.
Mol Ther Methods Clin Dev
; 18: 167-175, 2020 Sep 11.
Article
in English
| MEDLINE | ID: mdl-32637448
20.
Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn's disease: an open randomised trial.
Lancet
; 371(9613): 660-667, 2008 Feb 23.
Article
in English
| MEDLINE | ID: mdl-18295023