Effect of potassium channel blocker tetraethylammonium on proliferation and apoptosis of ovarian cancer cell / 解放军医学杂志

Objective To study the effects of potassium channel blocker,tetraethylammonium(TEA) on the proliferation and apoptosis of ovarian cancer cell line SKOV3.Methods SKOV3 cells were treated with TEA.The effect of TEA on proliferation of SKOV3 cells was assessed by MTT assay.Hoechst 33258 fluorescein staining and flow cytometry(FCM) were employed in detection of SKOV3 cells apoptosis.Results TEA(1,5,10 and 20mmol/L) can significantly inhibit the proliferation of SKOV3 cells,the inhibitory rates were 8.61%,18.86%,46.63% and 65.22%,respectively(P