1.
J Med Primatol
; 47(5): 298-301, 2018 10.
Article
in English
| MEDLINE
| ID: mdl-30255956
ABSTRACT
How SIV progenitors evolved into deadly HIV-1 and HIV-2 following initial cross-species transmission still remains a mystery. Here, we used humanized mice as a human surrogate system to evaluate SIVsm evolution into HIV-2. Increased viral virulence to human CD4+ T cells and adaptive genetic changes were observed during serial passages.