Search | VHL Search Portal

1.

A Bright Future for Antibiotics?

Matzov, Donna; Bashan, Anat; Yonath, Ada.

Annu Rev Biochem ; 86: 567-583, 2017 06 20.

Article in English | MEDLINE | ID: mdl-28654325

2.

A novel antibiotic class targeting the lipopolysaccharide transporter.

Zampaloni, Claudia; Mattei, Patrizio; Bleicher, Konrad; Winther, Lotte; Thäte, Claudia; Bucher, Christian; Adam, Jean-Michel; Alanine, Alexander; Amrein, Kurt E; Baidin, Vadim; Bieniossek, Christoph; Bissantz, Caterina; Boess, Franziska; Cantrill, Carina; Clairfeuille, Thomas; Dey, Fabian; Di Giorgio, Patrick; du Castel, Pauline; Dylus, David; Dzygiel, Pawel; Felici, Antonio; García-Alcalde, Fernando; Haldimann, Andreas; Leipner, Matthew; Leyn, Semen; Louvel, Séverine; Misson, Pauline; Osterman, Andrei; Pahil, Karanbir; Rigo, Sébastien; Schäublin, Adrian; Scharf, Sebastian; Schmitz, Petra; Stoll, Theodor; Trauner, Andrej; Zoffmann, Sannah; Kahne, Daniel; Young, John A T; Lobritz, Michael A; Bradley, Kenneth A.

Nature ; 625(7995): 566-571, 2024 Jan.

Article in English | MEDLINE | ID: mdl-38172634

3.

A Gram-negative-selective antibiotic that spares the gut microbiome.

Muñoz, Kristen A; Ulrich, Rebecca J; Vasan, Archit K; Sinclair, Matt; Wen, Po-Chao; Holmes, Jessica R; Lee, Hyang Yeon; Hung, Chien-Che; Fields, Christopher J; Tajkhorshid, Emad; Lau, Gee W; Hergenrother, Paul J.

Nature ; 630(8016): 429-436, 2024 Jun.

Article in English | MEDLINE | ID: mdl-38811738

4.

Molecular mechanisms underlying bacterial persisters.

Maisonneuve, Etienne; Gerdes, Kenn.

Cell ; 157(3): 539-48, 2014 Apr 24.

Article in English | MEDLINE | ID: mdl-24766804

5.

Meet the authors: Mirjana Lilic and Elizabeth Campbell.

Mol Cell ; 81(14): 2869-2870, 2021 07 15.

Article in English | MEDLINE | ID: mdl-34270941

6.

Structural basis of transcriptional activation by the Mycobacterium tuberculosis intrinsic antibiotic-resistance transcription factor WhiB7.

Lilic, Mirjana; Darst, Seth A; Campbell, Elizabeth A.

Mol Cell ; 81(14): 2875-2886.e5, 2021 07 15.

Article in English | MEDLINE | ID: mdl-34171296

7.

Antibiotic resistance in the patient with cancer: Escalating challenges and paths forward.

Nanayakkara, Amila K; Boucher, Helen W; Fowler, Vance G; Jezek, Amanda; Outterson, Kevin; Greenberg, David E.

CA Cancer J Clin ; 71(6): 488-504, 2021 11.

Article in English | MEDLINE | ID: mdl-34546590

8.

(p)ppGpp controls bacterial persistence by stochastic induction of toxin-antitoxin activity.

Maisonneuve, Etienne; Castro-Camargo, Manuela; Gerdes, Kenn.

Cell ; 154(5): 1140-1150, 2013 Aug 29.

Article in English | MEDLINE | ID: mdl-23993101

9.

Rational design of a new antibiotic class for drug-resistant infections.

Durand-Reville, Thomas F; Miller, Alita A; O'Donnell, John P; Wu, Xiaoyun; Sylvester, Mark A; Guler, Satenig; Iyer, Ramkumar; Shapiro, Adam B; Carter, Nicole M; Velez-Vega, Camilo; Moussa, Samir H; McLeod, Sarah M; Chen, April; Tanudra, Angela M; Zhang, Jing; Comita-Prevoir, Janelle; Romero, Jan A; Huynh, Hoan; Ferguson, Andrew D; Horanyi, Peter S; Mayclin, Stephen J; Heine, Henry S; Drusano, George L; Cummings, Jason E; Slayden, Richard A; Tommasi, Ruben A.

Nature ; 597(7878): 698-702, 2021 09.

Article in English | MEDLINE | ID: mdl-34526714

10.

A synthetic antibiotic class overcoming bacterial multidrug resistance.

Mitcheltree, Matthew J; Pisipati, Amarnath; Syroegin, Egor A; Silvestre, Katherine J; Klepacki, Dorota; Mason, Jeremy D; Terwilliger, Daniel W; Testolin, Giambattista; Pote, Aditya R; Wu, Kelvin J Y; Ladley, Richard Porter; Chatman, Kelly; Mankin, Alexander S; Polikanov, Yury S; Myers, Andrew G.

Nature ; 599(7885): 507-512, 2021 11.

Article in English | MEDLINE | ID: mdl-34707295

11.

Metabolomics-Driven Exploration of the Chemical Drug Space to Predict Combination Antimicrobial Therapies.

Campos, Adrian I; Zampieri, Mattia.

Mol Cell ; 74(6): 1291-1303.e6, 2019 06 20.

Article in English | MEDLINE | ID: mdl-31047795

12.

Peripheral positions encode transport specificity in the small multidrug resistance exporters.

Burata, Olive E; O'Donnell, Ever; Hyun, Jeonghoon; Lucero, Rachael M; Thomas, Junius E; Gibbs, Ethan M; Reacher, Isabella; Carney, Nolan A; Stockbridge, Randy B.

Proc Natl Acad Sci U S A ; 121(25): e2403273121, 2024 Jun 18.

Article in English | MEDLINE | ID: mdl-38865266

13.

Type II and IV toxin-antitoxin systems coordinately stabilize the integrative and conjugative element of the ICESa2603 family conferring multiple drug resistance in Streptococcus suis.

Gu, Qibing; Zhu, Xiayu; Yu, Yong; Jiang, Tao; Pan, Zihao; Ma, Jiale; Yao, Huochun.

PLoS Pathog ; 20(4): e1012169, 2024 Apr.

Article in English | MEDLINE | ID: mdl-38640137

14.

Pyrrole-based inhibitors of RND-type efflux pumps reverse antibiotic resistance and display anti-virulence potential.

Mahey, Nisha; Tambat, Rushikesh; Kalia, Ritu; Ingavale, Rajnita; Kodesia, Akriti; Chandal, Nishtha; Kapoor, Srajan; Verma, Dipesh Kumar; Thakur, Krishan Gopal; Jachak, Sanjay; Nandanwar, Hemraj.

PLoS Pathog ; 20(4): e1012121, 2024 Apr.

Article in English | MEDLINE | ID: mdl-38593161

15.

Harvesting and amplifying gene cassettes confers cross-resistance to critically important antibiotics.

Dulyayangkul, Punyawee; Beavis, Thomas; Lee, Winnie W Y; Ardagh, Robbie; Edwards, Frances; Hamilton, Fergus; Head, Ian; Heesom, Kate J; Mounsey, Oliver; Murarik, Marek; Pinweha, Peechanika; Reding, Carlos; Satapoomin, Naphat; Shaw, John M; Takebayashi, Yuiko; Tooke, Catherine L; Spencer, James; Williams, Philip B; Avison, Matthew B.

PLoS Pathog ; 20(6): e1012235, 2024 Jun.

Article in English | MEDLINE | ID: mdl-38843111

16.

Multidrug-resistant E. coli encoding high genetic diversity in carbohydrate metabolism genes displace commensal E. coli from the intestinal tract.

Connor, Christopher H; Zucoloto, Amanda Z; Munnoch, John T; Yu, Ian-Ling; Corander, Jukka; Hoskisson, Paul A; McDonald, Braedon; McNally, Alan.

PLoS Biol ; 21(10): e3002329, 2023 10.

Article in English | MEDLINE | ID: mdl-37847672

17.

Two birds with one stone: SGI1 can stabilize itself and expel the IncC helper by hijacking the plasmid parABS system.

Murányi, Gábor; Szabó, Mónika; Acsai, Károly; Kiss, János.

Nucleic Acids Res ; 52(5): 2498-2518, 2024 Mar 21.

Article in English | MEDLINE | ID: mdl-38300764

18.

Systematic interrogation of CRISPR antimicrobials in Klebsiella pneumoniae reveals nuclease-, guide- and strain-dependent features influencing antimicrobial activity.

Vialetto, Elena; Miele, Solange; Goren, Moran G; Yu, Jiaqi; Yu, Yanying; Collias, Daphne; Beamud, Beatriz; Osbelt, Lisa; Lourenço, Marta; Strowig, Till; Brisse, Sylvain; Barquist, Lars; Qimron, Udi; Bikard, David; Beisel, Chase L.

Nucleic Acids Res ; 52(10): 6079-6091, 2024 Jun 10.

Article in English | MEDLINE | ID: mdl-38661215

19.

Antimicrobial resistance heterogeneity among multidrug-resistant Gram-negative pathogens: Phenotypic, genotypic, and proteomic analysis.

Mehrotra, Tanshi; Konar, Dipasri; Pragasam, Agila Kumari; Kumar, Shakti; Jana, Pradipta; Babele, Prabhakar; Paul, Deepjyoti; Purohit, Ayushi; Tanwar, Subhash; Bakshi, Susmita; Das, Santanu; Verma, Jyoti; Talukdar, Daizee; Narendrakumar, Lekshmi; Kothidar, Akanksha; Karmakar, Sonali Porey; Chaudhuri, Susmita; Pal, Sujoy; Jain, Kajal; Srikanth, Chittur V; Sankar, M Jeeva; Atmakuri, Krishnamohan; Agarwal, Ramesh; Gaind, Rajni; Ballal, Mamatha; Kammili, Nagamani; Bhadra, Rupak K; Ramamurthy, Thandavarayan; Nair, G Balakrish; Das, Bhabatosh.

Proc Natl Acad Sci U S A ; 120(33): e2305465120, 2023 08 15.

Article in English | MEDLINE | ID: mdl-37549252

20.

Klebicin E, a pore-forming bacteriocin of Klebsiella pneumoniae, exploits the porin OmpC and the Ton system for translocation.

Zhao, Xinxin; Wang, Wenyu; Zeng, Xiaoli; Xu, Rong; Yuan, Bing; Yu, Wenyao; Wang, Mingshu; Jia, Renyong; Chen, Shun; Zhu, Dekang; Liu, Mafeng; Yang, Qiao; Wu, Ying; Zhang, Shaqiu; Huang, Juan; Ou, Xumin; Sun, Di; Cheng, Anchun.

J Biol Chem ; 300(3): 105694, 2024 Mar.

Article in English | MEDLINE | ID: mdl-38301890

VHL Search Portal

Information and Knowledge for Health

Config filters

Your selection (0)

Export format:

Export: