ABSTRACT
Mycosis fungoides palmaris et plantaris (MFPP) is a rare variant of mycosis fungoides (MF), a type of cutaneous T-cell lymphoma. MFPP primarily affects the palms and soles of the feet and is often misdiagnosed as dyshidrotic eczema due to its similar clinical presentation. This case report presents a middle-aged woman with MFPP whose initial presentation was mistaken for dyshidrotic eczema. Despite treatment with topical corticosteroids, the patient's lesions persisted, prompting further investigations that led to the diagnosis of MFPP. The patient was initiated on betamethasone dipropionate ointment and hydroxyzine for pruritus management, with a pivotal referral to oncology for comprehensive evaluation. This case highlights the importance of considering MFPP in the differential diagnosis of persistent eczematous lesions on the palms and soles, especially when treatment with topical corticosteroids is ineffective. J Drugs Dermatol. 2024;23(7):569-570. doi:10.36849/JDD.8474.
Subject(s)
Eczema, Dyshidrotic , Mycosis Fungoides , Skin Neoplasms , Humans , Female , Mycosis Fungoides/diagnosis , Mycosis Fungoides/drug therapy , Mycosis Fungoides/pathology , Diagnosis, Differential , Middle Aged , Eczema, Dyshidrotic/diagnosis , Eczema, Dyshidrotic/drug therapy , Skin Neoplasms/diagnosis , Skin Neoplasms/pathology , Skin Neoplasms/drug therapy , Betamethasone/administration & dosage , Betamethasone/analogs & derivativesABSTRACT
BACKGROUND: Palmoplantar pustulosis (PPP) and pompholyx are chronic diseases characterized by pustules and vesicles on the palms and soles. These disorders often have similar clinicopathological features, which lead to diagnostic difficulties. We aimed to investigate the expression patterns of keratins and involucrin in PPP and pompholyx using immunohistochemical staining. METHODS: Skin biopsies from patients with PPP (n = 40) and pompholyx (n = 22) were immunohistochemically analyzed for Keratin 5, 9, 14, and involucrin expression. RESULTS: K5 expression was higher in PPP than in pompholyx, with diffusely positive expression in the basal, spinous, and granular layers. K14 expression did not differ between groups. K9 expression was observed near the pompholyx vesicle (P = 0.014) and stratum spinosum (P < 0.001) but was almost absent around PPP pustules. Involucrin expression was diffused around the PPP pustules and partially around the pompholyx vesicles, but without statistical significance (P = 0.123). Involucrin expression was elevated in the basal layer of the PPP compared with that in the pompholyx (P = 0.023). CONCLUSION: PPP and pompholyx exhibited distinctive differentiation in the expression of K5, K9, and involucrin.
Subject(s)
Immunohistochemistry , Keratins , Protein Precursors , Psoriasis , Humans , Protein Precursors/metabolism , Protein Precursors/analysis , Psoriasis/metabolism , Psoriasis/pathology , Psoriasis/diagnosis , Male , Female , Keratins/metabolism , Keratins/analysis , Middle Aged , Adult , Diagnosis, Differential , Aged , Young Adult , Eczema, Dyshidrotic/diagnosis , Eczema, Dyshidrotic/metabolism , Eczema, Dyshidrotic/pathology , Biopsy , Adolescent , Skin/pathology , Skin/metabolism , Keratin-9/metabolism , Keratin-9/analysis , Keratin-14/metabolism , Keratin-14/analysisABSTRACT
La hidradenitis palmoplantar idiopática (HPPI) es una dermatosis neutrofílica que cursa con placas eritematoso-edematosas en las plantas de los pies y, en ocasiones, en las palmas de las manos. Estas lesiones se presentan en niños sin antecedentes de medicación ni manifestaciones sistémicas. Se postula que determinados factores mecánicos afectarían a las glándulas ecrinas inmaduras. El tratamiento es controvertido, aunque se ha observado que se puede manejar de forma conservadora. Por otro lado, el diagnóstico histológico, que presenta hallazgos típicos, no sería necesario realizarlo en todos los casos, puesto que la mayoría presenta una clínica característica con resolución espontánea en menos de 3 semanas. Presentamos dos casos de HPPI en niños (AU)
Idiopathic palmoplantar hidradenitis (IPPH) is a neutrophilic dermatosis that causes erythematous plaques in plants and sometimes in palms. These injuries occur in children with no history of medication or systemic manifestations. It is postulated that mechanical factors affect immature eccrine glands. The treatment is controversial, although we know that it can be conservatively managed. On the other hand, histological diagnosis, which presents typical findings, would not be necessary in all cases, since most of them present characteristic symptoms and spontaneous remission in less than three weeks. We present two cases of IPPH in children (AU)
Subject(s)
Humans , Male , Child, Preschool , Child , Hidradenitis/complications , Hidradenitis/diagnosis , Sweat Glands/anatomy & histology , Erythema/complications , Diagnosis, Differential , Rest , Analgesics/therapeutic use , Eczema, Dyshidrotic/complications , Eczema, Dyshidrotic/diagnosis , Sweating , Foot Injuries/complicationsABSTRACT
Background: Pompholyx is a type of hand eczema which is characterized by recurrent vesicles and bullae.It is seen commonly in the age group 20 -40 years, affects all races and has an equal sex distribution. It is commonly associated with contact allergic dermatitis and contact irritant dermatitis and atopy. Other associated factors include emotional stress, chronic illness such as HIV and physiological states like pregnancy. Pompholyx is said to be common in warm climate. In which the study area can be classified as such being a tropical climate in the Sub Saharan Africa. Pompholyx is a disease that reduces the quality of living of affected individuals and can bea cause of social stigmatization, often mistaken for a contagious infection such as scabies. It can also be a cause great discomfort to the body and mind leading to work and school absenteeism. Methodology:It was a retrospective cross sectional study of new pompholyx cases within the period of January 2006 to December 2015 from the new patient clinical register. Folders were retrieved and data was extracted using a semi-structured questionnaire developed from standard written medical literature on pompholyx. Data was analyzed using Statistical Package for Social Sciences version 20.Results:Thirty six new cases of pompholyx were seen within the period with an average incidence of 0.59% over the ten year period consisting of 22 females and 14 males with age range of 2- 65years.There was no statistical significant relationship between age categories and sex. The majority of cases were seen amongst students. The age 20-45 group constituted the highest number. 61% had a history of contact dermatitis with the major triggers being detergents, chemicals and metals. All patients were counseled and improved after receiving treatment from at least two of the five major classes of drugs- corticosteroids, antifungal, antibiotics, antihistamines and astringents. Conclusion:Pompholyx is a recurrent hand dermatitis characterized by vesicles and bullae though not common as the study reflects; it can be a source of mental and physical discomfort leading to a poor quality of life in affected individuals
Subject(s)
Dermatitis, Allergic Contact/epidemiology , Eczema, Dyshidrotic/diagnosis , Eczema, Dyshidrotic/epidemiology , NigeriaABSTRACT
No disponible
Subject(s)
Humans , Male , Middle Aged , Aged , Eczema, Dyshidrotic/chemically induced , Eczema, Dyshidrotic/diagnosis , Eczema, Dyshidrotic/pathology , Immunoglobulins, Intravenous/adverse effects , Immunoglobulins, Intravenous/analysis , Immunoglobulins, Intravenous/immunology , Physical Examination/instrumentation , Physical Examination/methods , Physical Examination , Diagnosis , Adrenal Cortex Hormones/pharmacology , Adrenal Cortex Hormones/therapeutic use , Serologic Tests/instrumentation , Serologic Tests/methods , Serologic Tests , Skin Diseases/diagnosis , Skin Diseases/pathology , Skin Diseases/therapyABSTRACT
No disponible
Subject(s)
Humans , Female , Middle Aged , Eczema, Dyshidrotic/diagnosis , Linear IgA Bullous Dermatosis/diagnosis , Immunoglobulin A , Keratoderma, Palmoplantar/diagnosis , Diagnosis, DifferentialABSTRACT
El penfigoide dishidrosiforme es una variante de penfigoide ampolloso localizado. Se caracteriza por la presencia de vesículas sero-hemorrágicas en palmas y/o plantas que recuerdan el eccema dishidrótico. La mayoría de pacientes responden a corticoterapia oral a dosis bajas. Presentamos el caso de un varón de 54 años que consultó por lesiones vesiculosas en palmas y plantas que habían sido tratadas con corticoide tópicos in respuesta. Iniciamos corticoterapia a dosis baja, con remisión completa del cuadro a las 2 semanas (AU)
Dyshidrosiform pemphigoid is a localized variant of bullous pemphigoid. It appears as a vesicular eruption with serohemorrhagic content on the palms and/or the soles, similarly to the dyshidrotic eczema. Most of the patients show a good response with low-dose oral corticotherapy. We present the case of a 54-year-old male who was admitted with vesicular lesions on palms and soles, which had not improved with topical corticotherapy. He was treated with low-dose corticotherapy with complete remission after two weeks (AU)
Subject(s)
Humans , Male , Middle Aged , Pemphigoid, Bullous/diagnosis , Eczema, Dyshidrotic/diagnosis , Adrenal Cortex Hormones/therapeutic useABSTRACT
Se llevó a cabo un estudio de 89 pacientes portadores de lesiones de aspecto dishidrótico, desde diciembre de 1990 hasta marzo de 1994. El grupo estaba constituido por 55 mujeres y 34 varones, con un promedio de edad de 37,7 años. A todos los pacientes se les realizó rutina de laboratorio, parasitológico de materia fecal y estudios micológicos de la lesión, hallándose en estos últimos un 55 por ciento de positividad (siendo en su mayoría T. rubrum). Esto nos permitió inferir que en realidad se trataban de verdaderas tiñas, a pesar de cumplir con algunas de las cuatro variantes clínicas de la enfermedad (vesiculosa-descamativa-pustulosa o ampollar), por lo que consideramos que es imprescindible el estudio micológico de estas lesiones (AU)
Subject(s)
Humans , Male , Female , Adult , Eczema, Dyshidrotic/diagnosis , Eczema, Dyshidrotic/etiology , Eczema, Dyshidrotic/pathology , Dermatomycoses/diagnosis , Toes/pathology , Tinea/complications , Tinea/diagnosis , Tinea Pedis/complications , Tinea Pedis/diagnosis , Trichophyton/pathogenicityABSTRACT
Se llevó a cabo un estudio de 89 pacientes portadores de lesiones de aspecto dishidrótico, desde diciembre de 1990 hasta marzo de 1994. El grupo estaba constituido por 55 mujeres y 34 varones, con un promedio de edad de 37,7 años. A todos los pacientes se les realizó rutina de laboratorio, parasitológico de materia fecal y estudios micológicos de la lesión, hallándose en estos últimos un 55 por ciento de positividad (siendo en su mayoría T. rubrum). Esto nos permitió inferir que en realidad se trataban de verdaderas tiñas, a pesar de cumplir con algunas de las cuatro variantes clínicas de la enfermedad (vesiculosa-descamativa-pustulosa o ampollar), por lo que consideramos que es imprescindible el estudio micológico de estas lesiones
Subject(s)
Humans , Male , Female , Adult , Eczema, Dyshidrotic/diagnosis , Dermatomycoses/diagnosis , Eczema, Dyshidrotic/etiology , Eczema, Dyshidrotic/pathology , Tinea Pedis/complications , Tinea Pedis/diagnosis , Tinea/complications , Tinea/diagnosis , Toes/pathology , Trichophyton/pathogenicityABSTRACT
O autor realizou um estudo prospectivo em 600 pacientes portadores de disdrose. Após uma revisäo bibliográfica a respeito mostra os resultados obtidos em relaçäo ao sexo, raça, idade, profissäo, localizaçöes das lesöes, meses de freqüência e possíveis causas etiológicas
Subject(s)
Infant, Newborn , Infant , Child, Preschool , Child , Adolescent , Adult , Middle Aged , Humans , Male , Female , Drug Eruptions , Sweating/drug effects , Brazil , Dermatitis, Atopic/genetics , Eczema, Dyshidrotic/diagnosis , Eczema/etiology , Foot Dermatoses/epidemiology , Hand Dermatoses/epidemiology , Prospective StudiesABSTRACT
La fluoxetina es uno de los fármacos antidepresivos más utilizados actualmente. Entre sus efectos secundarios está la hiperhidrosis. Presentamos los casos de dos pacientes en tratamiento con fluoxetina por parte del Servicio de Psiquiatría de nuestro hospital que acudieron al Servicio de Dermatología por presentar ambos un cuadro de intensa hiperhidrosis localizada, el primero a nivel del cuero cabelludo y el segundo en axilas, palmas y plantas. En ambos casos los síntomas cedieron tras retirar el fármaco. (AU)