Subject(s)
Common Variable Immunodeficiency , Fever , Liver Diseases , Liver , Splenomegaly , Aged , Humans , Male , Anti-Bacterial Agents/therapeutic use , Bacterial Infections/diagnosis , Bacterial Infections/drug therapy , Bacterial Infections/etiology , Bone Marrow/pathology , Common Variable Immunodeficiency/complications , Common Variable Immunodeficiency/diagnosis , Common Variable Immunodeficiency/therapy , Diagnosis, Differential , Digestive System Diseases/diagnosis , Digestive System Diseases/diagnostic imaging , Digestive System Diseases/drug therapy , Digestive System Diseases/etiology , Disease Progression , Fever/etiology , Granuloma/diagnostic imaging , Granuloma/drug therapy , Granuloma/etiology , Liver/pathology , Liver/diagnostic imaging , Liver Diseases/diagnostic imaging , Liver Diseases/drug therapy , Liver Diseases/etiology , Liver Neoplasms/pathology , Magnetic Resonance Imaging , Multiple Pulmonary Nodules/diagnostic imaging , Multiple Pulmonary Nodules/drug therapy , Multiple Pulmonary Nodules/etiology , Recurrence , Relapsing Fever/diagnosis , Relapsing Fever/drug therapy , Relapsing Fever/etiology , Splenomegaly/diagnostic imaging , Splenomegaly/drug therapy , Splenomegaly/etiology , Tomography, X-Ray ComputedABSTRACT
Objective: To evaluate the safety and feasibility of robotic-assisted thoracoscopic day surgery for pulmonary nodules. Methods: Clinical data of 523 patients with pulmonary nodule underwent robotic-assisted thoracoscopic surgery in the Department of Thoracic Surgery, Xiangya Hospital, Central South University from January 2021 to June 2022 were retrospectively analyzed, which including 223 males and 300 females, aged from 19 to 72 (54.0±11.7) years. Those patients were divided into the day surgery group (DSG) and inpatient surgery group (ISG) according to perioperative management methods. Propensity score matching (PSM) (1â¶2) was performed according to the general baseline information, T stage of the tumor, surgery approach, and tumor position, and a total of 178 patients were finally included. Clinical outcomes of DSG were observed. The differences in incidence of postoperative complications, treatment-related costs and resource consumption between DSG and ISG were compared. Subgroup analysis was performed according to surgery method to evaluate the difference between DSG and ISG in lobectomy and sublobectomy. Results: In 81 cases DSG, eight patients were transferred to thoracic surgery ward, and the day surgery discharge rate was 90% (73/81). There was no statistically significant difference in incidence of postoperative complications between DSG and ISG (P=0.612). The length of stay after surgery, period of chest draining, average hospital cost, and drug cost of DSG were statistically significant lower than ISG, ((2.19±0.84) vs (4.74±1.81) days, (1.70±0.65) vs (3.45±1.85) days, (6.64±0.74) vs (8.29±0.97)×104 CNY, (0.35±0.07) vs (0.69±0.18)×104 CNY), respectively(all P<0.05). The drainage volume and VAS score at discharge in DSG and ISG group were(220.47±120.02) ml and(242.21±129.96) ml, 1.68±0.79 and 1.64±0.91, respectively, with no statistically significant difference (P>0.05). In subgroup analysis, there was no statistically significant difference in incidence of postoperative complications, drainage volume after surgery and VAS score at discharge between DSG and ISG both for lobectomy and sublobectomy patients. And the results of the length of stay after surgery, period of chest draining, and drug cost in DSG were also significantly lower than ISG (P<0.05). Conclusions: Robotic-assisted thoracoscopic day surgery for pulmonary nodule is safe and feasible, with the advantage of short length of stay after surgery, short period of chest draining, less average hospital cost and drug cost. There is no difference in incidence of postoperative complications between DSG and ISG.
Subject(s)
Lung Neoplasms , Multiple Pulmonary Nodules , Robotic Surgical Procedures , Male , Female , Humans , Retrospective Studies , Thoracic Surgery, Video-Assisted/adverse effects , Thoracic Surgery, Video-Assisted/methods , Propensity Score , Feasibility Studies , Ambulatory Surgical Procedures , Length of Stay , Multiple Pulmonary Nodules/etiology , Multiple Pulmonary Nodules/surgery , Postoperative Complications/epidemiology , Postoperative Complications/etiology , Lung Neoplasms/surgery , Lung Neoplasms/pathology , Pneumonectomy/adverse effectsABSTRACT
BACKGROUND: The detection rate of lung nodules has increased significantly among petroleum workers in North China since the low-dose CT (LDCT) screening has been widely carried out. What's more, the number of confirmed early lung cancers is increasing continuously. Therefore, a great deal of concern for the high risk of lung cancer has been shown among petroleum workers. PURPOSE: To improve the screening efficiency and maximize the benefits of the subjects, the current situation of LDCT lung cancer screening should be understood and the imaging characteristics of early lung cancer should be analyzed for petroleum workers in North China. MATERIALS AND METHODS: Firstly, the dynamic changes of LDCT early lung cancer screening for petroleum workers in North China were analyzed in recent years. Then, the survey data of 3121 petroleum workers was compared with that of 1868 non-petroleum workers, which was analyzed. Finally, 91 patients (129 nodular lung cancer) confirmed by pathology were retrospectively analyzed, and the data of which was compared with the clinical features obtained from survey data above. The imaging characteristics and related factors of different subtypes of lung adenocarcinoma were discussed and analyzed. RESULTS: Lung nodules were found in 810 cases (25.95%) out of 3121 petroleum workers; and the surgery was chosen by 42 patients, 38 of whom were confirmed as lung cancer. Compared with the data of screened petroleum workers, there were more older people and more females as well as a higher proportion of people with family malignancy history, and a lower proportion of smoking people in 91 patients with lung cancer. As the pathological grade of tumor nodules increased, the volume and diameter of nodules gradually increased, and the mean density, maximum density and standard deviation of density also increased (p < 0.001). The volume and diameter of nodules were positively correlated with ages (p < 0.05). CONCLUSION: The occurrence of lung adenocarcinoma is closely related to the family history of malignant tumors, and the constituent ratio of young women without a history of smoking increased significantly. At the same time, the quantitative information obtained by using CT images has important value in predicting its pathological subtypes.
Subject(s)
Adenocarcinoma of Lung/diagnostic imaging , Early Detection of Cancer , Lung Neoplasms/diagnostic imaging , Multiple Pulmonary Nodules/diagnostic imaging , Occupational Diseases/diagnostic imaging , Occupational Health , Oil and Gas Industry , Solitary Pulmonary Nodule/diagnostic imaging , Tomography, X-Ray Computed , Adenocarcinoma of Lung/etiology , Adenocarcinoma of Lung/pathology , Adenocarcinoma of Lung/surgery , Adult , Biopsy , China , Female , Health Surveys , Humans , Lung Neoplasms/etiology , Lung Neoplasms/pathology , Lung Neoplasms/surgery , Male , Middle Aged , Multiple Pulmonary Nodules/etiology , Multiple Pulmonary Nodules/pathology , Multiple Pulmonary Nodules/surgery , Neoplasm Grading , Occupational Diseases/etiology , Occupational Diseases/pathology , Occupational Diseases/surgery , Predictive Value of Tests , Retrospective Studies , Risk Assessment , Risk Factors , Solitary Pulmonary Nodule/etiology , Solitary Pulmonary Nodule/pathology , Solitary Pulmonary Nodule/surgery , Tumor BurdenABSTRACT
In esophageal cancer, metastatic spread to the lungs is detected in 4-9.7% of cases. During staging investigations, 22% of patients have pulmonary nodules detected on cross-sectional imaging. The purpose of this study is to elucidate the clinical importance of these incidentally found pulmonary nodules, in patients with clinically localized esophageal cancer. A retrospective cohort study was conducted from January 2008 to December 2012 in a tertiary esophagogastric referral center. One-hundred and forty-nine patients were included in the study. All patients underwent dedicated staging followed by neoadjuvant chemotherapy and surgery as indicated. Thirty-three (22.1%) patients had pulmonary nodules found in their preoperative staging. Only three (9%) patients proved to develop metastatic pulmonary disease on follow-up. Interestingly, in all three patients, the nodules were negative on initial 18-fluorodeoxyglucose positron emission tomography. Incidentally found pulmonary nodules in newly diagnosed patients with esophageal cancer during staging investigations are rarely metastases. Such nodules, in isolation, should not preclude patients from radical treatment.
Subject(s)
Chemoradiotherapy/methods , Esophageal Neoplasms , Esophagectomy/methods , Lung Neoplasms , Multiple Pulmonary Nodules , Clinical Decision-Making , Esophageal Neoplasms/epidemiology , Esophageal Neoplasms/pathology , Esophageal Neoplasms/surgery , Female , Fluorodeoxyglucose F18/pharmacology , Humans , Incidental Findings , Lung Neoplasms/epidemiology , Lung Neoplasms/pathology , Lung Neoplasms/secondary , Lung Neoplasms/surgery , Male , Middle Aged , Multiple Pulmonary Nodules/diagnostic imaging , Multiple Pulmonary Nodules/epidemiology , Multiple Pulmonary Nodules/etiology , Prognosis , Radiopharmaceuticals/pharmacology , Retrospective Studies , Tomography, X-Ray Computed/methods , United Kingdom/epidemiologyABSTRACT
The case of a 10-year-old child with sickle cell disease with pulmonary nodules and prolonged fevers is reported here. The child was first diagnosed with sarcoidosis based on lung biopsy, but unresponsiveness to therapy led to a second lung biopsy, which revealed the true diagnosis of mycobacterium avium complex disease. Multiple possible explanations for why the patient became infected exist. The patient was baseline immunocompromised due to her sickle cell disease, was exposed to invasive procedures, was taking medications that may predispose to this type of infection, and was found to have a congenital immunodeficiency.
Subject(s)
Anemia, Sickle Cell/complications , Multiple Pulmonary Nodules/diagnosis , Mycobacterium avium Complex/isolation & purification , Mycobacterium avium-intracellulare Infection/diagnosis , Tuberculosis, Pulmonary/diagnosis , Child , Diagnosis, Differential , Female , Humans , Multiple Pulmonary Nodules/etiology , Mycobacterium avium-intracellulare Infection/etiology , Prognosis , Tuberculosis, Pulmonary/etiologySubject(s)
Histoplasma/isolation & purification , Histoplasmosis/diagnosis , Lung Diseases, Fungal/diagnosis , Melanoma/complications , Multiple Pulmonary Nodules/diagnostic imaging , Skin Neoplasms/complications , Biopsy , Female , Histoplasmosis/microbiology , Histoplasmosis/pathology , Humans , Lung/diagnostic imaging , Lung/microbiology , Lung/pathology , Lung Diseases, Fungal/microbiology , Lung Diseases, Fungal/pathology , Middle Aged , Multiple Pulmonary Nodules/etiology , Neoplasm Recurrence, Local , Tomography, X-Ray Computed , Melanoma, Cutaneous MalignantABSTRACT
BACKGROUND: Benign metastatic leiomyoma (BML) is an extremely rare disease. Although uterine leiomyomas are benign histologically, they can metastasize to distant sites. While the incidence is very low, the lung is the organ most frequently affected by BML. Pulmonary BML usually presents as numerous well-defined nodules of various sizes, while the cavitary or cystic features in the nodules are rarely observed on radiologic images. CASE PRESENTATION: A 52-year-old woman complained of cough and dyspnea for one month. She had been previously diagnosed with uterine leiomyoma and had undergone total hysterectomy about 14 years prior. High-resolution computed tomography (CT) images showed that there were multiple cystic nodules of various sizes in both lungs. Pathologic examination revealed that the pulmonary nodule had complex branching glandular structures lined by a single layer of simple cuboidal to columnar epithelium that was surrounded by abundant spindle cells. Additional immunohistochemistry data suggested that pulmonary nodule diagnosis was BML-associated uterine leiomyoma. CONCLUSION: In this report, we introduce an interesting case of pulmonary BML that presented as a combination of various kinds of nodules including simple round nodules, simple cysts, and cysts with a solid portion, which are very rare radiologic features of BML in lung. In addition, when the patient is a woman of reproductive age, physicians should meticulously review the gynecological history and suspect BML when there are various cystic pulmonary lesions.
Subject(s)
Leiomyoma/complications , Leiomyoma/surgery , Lung Neoplasms/etiology , Lung Neoplasms/physiopathology , Multiple Pulmonary Nodules/etiology , Neoplasm Metastasis/physiopathology , Uterine Neoplasms/complications , Female , Humans , Leiomyoma/diagnostic imaging , Leiomyoma/physiopathology , Middle Aged , Multiple Pulmonary Nodules/physiopathology , Tomography, X-Ray Computed , Treatment Outcome , Uterine Neoplasms/diagnostic imaging , Uterine Neoplasms/physiopathologySubject(s)
Alveolar Epithelial Cells/pathology , Angiomyolipoma/drug therapy , Antineoplastic Agents/therapeutic use , Everolimus/therapeutic use , Kidney Neoplasms/drug therapy , Multiple Pulmonary Nodules/diagnostic imaging , Tuberous Sclerosis/drug therapy , Adult , Angiomyolipoma/etiology , Anti-Asthmatic Agents/therapeutic use , Asthma/diagnosis , Asthma/drug therapy , Humans , Hyperplasia , Kidney Neoplasms/etiology , Lung/pathology , Male , Multiple Pulmonary Nodules/etiology , Multiple Pulmonary Nodules/pathology , Tomography, X-Ray Computed , Treatment Outcome , Tuberous Sclerosis/complicationsABSTRACT
Kaposi sarcoma (KS) is a multifocal systemic disease that originates in the vascular endothelium related to Human Herpes Virus 8 (HHV-8). In the early 1980s the first series of cases of disseminated Kaposi Sarcoma in HIV infected patients were reported. However, with the advent of highly active antiretroviral therapy (HAART) since 1997, these cases are less frequently observed by clinicians. We report the case of a 40-year-old woman, presenting with two asymptomatic purpuric nodules localized in the superior and inferior left eyelids, occluding the palpebral fissure, which were present for 4 months prior to presentation. The eyelid nodules were determined to represent KS, but there were no additional cutaneous lesions. Pulmonary and gastric KS involvement was documented. Antiretroviral therapy was initiated along with pegylated liposomal doxorubicin. The nodules gradually disappeared and her immune status eventually improved. Ocular and periorbital involvement of KS associated with HIV-1 infection as the initial clinical manifestations is a rare advent. This case is important as it illustrates that disseminated KS was not to be predicted by the number or the extension of cutaneous lesions.
Subject(s)
Acquired Immunodeficiency Syndrome/complications , Eyelid Neoplasms/etiology , Lung Neoplasms/etiology , Multiple Pulmonary Nodules/etiology , Sarcoma, Kaposi/etiology , Acquired Immunodeficiency Syndrome/diagnosis , Acquired Immunodeficiency Syndrome/drug therapy , Adult , Antibiotics, Antineoplastic/therapeutic use , Antiretroviral Therapy, Highly Active , Doxorubicin/analogs & derivatives , Doxorubicin/therapeutic use , Eyelid Neoplasms/diagnosis , Eyelid Neoplasms/drug therapy , Eyelid Neoplasms/pathology , Female , HIV-1 , Humans , Lung Neoplasms/diagnostic imaging , Lung Neoplasms/drug therapy , Lung Neoplasms/pathology , Multiple Pulmonary Nodules/diagnostic imaging , Multiple Pulmonary Nodules/pathology , Polyethylene Glycols/therapeutic use , Radiography, Thoracic , Sarcoma, Kaposi/diagnosis , Sarcoma, Kaposi/drug therapy , Sarcoma, Kaposi/pathology , Tomography, X-Ray ComputedABSTRACT
A 9-year-old boy was admitted to Xiangya Hospital due to pain after trauma in the left lower limb for 5 days and fever with generalized pain for 2 days. The results of X-ray of the left lower limb were normal. Pulmonary computed tomography (CT) showed multiple pulmonary nodules in both lungs. Adrenal CT showed marked enlargement of the left adrenal gland. The patient also experienced generalized herpes and intermittent delirium and had a blood pressure up to 155/93 mm Hg. He was transferred to our hospital with a suspected diagnosis of pheochromocytoma. On admission, the patient had a blood pressure of 86/44 mm Hg, sporadic maculopapule and herpes, touch-evoked pain, exposure of superficial veins, white pus coating on the right side of the tongue, and tension in the abdominal muscle. No skin damage was observed in the left lower limb, and the patient was forced to be in the extending position and experienced significant swelling below the knees. Laboratory examination showed a reduction in platelet count, hypoproteinemia, a significant increase in creatase, a C-reactive protein level of 348 mg/L, and a procalcitonin level of >100 ng/mL. Thoracoabdominal and pelvic CT showed multiple patchy and nodular lesions in both lungs, which had an undetermined nature, as well as an enlarged spleen. The tests of puncture fluid from the left knee joint and the periosteum of the left tibia, blood culture, and bone marrow culture all showed methicillin-resistant Staphylococcus aureus. The patient was given anti-shock treatment, anti-infective therapy with vancomycin, debridement and continuous irrigation/drainage of osteomyelitis lesions in the left tibia, but the patient still experienced recurrent shivering and severe fever and increased subcutaneous and pulmonary nodules. Linezolid was added on day 8 after admission, and the patient's body temperature returned to normal on day 24 after admission. Subcutaneous and pulmonary nodules were gradually reduced and disappeared. The patient was treated for 2 months and then evaluated as cured.
Subject(s)
Fever/etiology , Methicillin-Resistant Staphylococcus aureus , Multiple Pulmonary Nodules/etiology , Pain/etiology , Staphylococcal Infections/complications , Child , Humans , Male , Staphylococcal Infections/drug therapy , Tomography, X-Ray ComputedABSTRACT
Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is recognized as a preneoplastic condition by the World Health Organization. We reviewed our experience with 30 patients and performed a systematic review of the English literature to collect best evidence on the clinical features and disease course in 169 additional patients. Some patients presented with one or more carcinoid tumors associated with multiple small pulmonary nodules on imaging studies and showed DIPNECH as a somewhat unexpected pathologic finding. Others presented with multiple small pulmonary nodules that raised suspicion of metastatic disease on imaging. A third subset was presented with previously unexplained respiratory symptoms. In most patients, DIPNECH was associated with a good prognosis, with chronological progression into a subsequent carcinoid tumor noted in only one patient and death attributed directly to DIPNECH in only two patients. There is no best evidence to support the use of octreotide, steroids, or bronchodilators in DIPNECH patients.
Subject(s)
Carcinoid Tumor/therapy , Lung Diseases/therapy , Lung Neoplasms/therapy , Lung/pathology , Neuroendocrine Cells/pathology , Precancerous Conditions/therapy , Adult , Aged , Aged, 80 and over , Antineoplastic Agents, Hormonal/therapeutic use , Carcinoid Tumor/complications , Carcinoid Tumor/diagnosis , Cough/etiology , Disease Progression , Dyspnea/etiology , Female , Humans , Hyperplasia/complications , Hyperplasia/diagnosis , Hyperplasia/therapy , Lung Diseases/complications , Lung Diseases/diagnosis , Lung Neoplasms/complications , Lung Neoplasms/diagnosis , Male , Middle Aged , Multiple Pulmonary Nodules/diagnostic imaging , Multiple Pulmonary Nodules/etiology , Multiple Pulmonary Nodules/therapy , Pneumonectomy , Precancerous Conditions/complications , Precancerous Conditions/diagnosis , Radiography , Respiratory Function Tests , Retrospective Studies , Somatostatin/analogs & derivatives , Somatostatin/therapeutic use , Treatment OutcomeSubject(s)
Antibodies, Monoclonal, Humanized/therapeutic use , Crohn Disease/drug therapy , Lung Diseases/etiology , Multiple Pulmonary Nodules/etiology , Necrobiotic Disorders/etiology , Adult , Antibodies, Monoclonal, Humanized/adverse effects , Crohn Disease/complications , Crohn Disease/pathology , Diagnosis, Differential , Humans , Lung/diagnostic imaging , Lung/pathology , Lung Diseases/diagnosis , Lung Diseases/diagnostic imaging , Lung Diseases/pathology , Male , Multiple Pulmonary Nodules/diagnosis , Multiple Pulmonary Nodules/diagnostic imaging , Multiple Pulmonary Nodules/pathology , Necrobiotic Disorders/diagnosis , Necrobiotic Disorders/diagnostic imaging , Necrobiotic Disorders/pathology , Tomography, X-Ray ComputedSubject(s)
Etanercept , Infliximab , Lung , Multiple Pulmonary Nodules , Sarcoidosis, Pulmonary , Spondylitis, Ankylosing/drug therapy , Adult , Biopsy/methods , Bronchoalveolar Lavage Fluid/cytology , Bronchoalveolar Lavage Fluid/microbiology , Diagnosis, Differential , Drug Substitution/methods , Etanercept/administration & dosage , Etanercept/adverse effects , Female , Humans , Infliximab/administration & dosage , Infliximab/adverse effects , Lung/diagnostic imaging , Lung/pathology , Multiple Pulmonary Nodules/diagnostic imaging , Multiple Pulmonary Nodules/etiology , Remission, Spontaneous , Sarcoidosis, Pulmonary/diagnosis , Sarcoidosis, Pulmonary/drug therapy , Sarcoidosis, Pulmonary/etiology , Sarcoidosis, Pulmonary/physiopathology , Tomography, X-Ray Computed/methods , Treatment Outcome , Tumor Necrosis Factor Inhibitors/administration & dosage , Tumor Necrosis Factor Inhibitors/adverse effects , Withholding TreatmentSubject(s)
Multiple Pulmonary Nodules/etiology , Multiple Pulmonary Nodules/surgery , Thoracic Diseases/complications , Thoracic Diseases/surgery , Humans , Male , Middle Aged , Multiple Pulmonary Nodules/physiopathology , Rare Diseases/complications , Rare Diseases/physiopathology , Rare Diseases/surgery , Thoracic Diseases/physiopathology , Treatment OutcomeABSTRACT
This report describes a 2-year-old collie dog with pulmonary nodules, visualized by computed tomographic (CT) scan, with evidence of Bartonella henselae bacteremia and pyogranulomatous lymphadenitis. Clinical signs resolved with antimicrobial therapy.
Lymphadénite pyogranulomateuse mandibulaire latérale et nodules pulmonaires chez un chien atteint de bactériémie àBartonella henselae. Ce rapport décrit un chien Collie âgé de 2 ans atteint de nodules pulmonaires, visualisés par tomodensitométrie, avec des signes de bactériémie à Bartonella henselae et de lymphadénite pyogranulomateuse. Les signes cliniques se sont résorbés avec un traitement antimicrobien.(Traduit par Isabelle Vallières).