ABSTRACT
OBJECTIVE: To assess the clinical efficacy and safety of potassium titanyl phosphate (KTP) laser treatment and electrocoagulation (EC) for the treatment of spider nevi (SN). METHOD: A randomized single-blind intrapatient comparison study was performed. A blinded observer and patients reported the clinical treatment outcome and pain on a visual analogue scale (0-10). Side effects were noted if present. RESULTS: Mean physician-rated clinical efficacy scores+/-standard error of the mean were 7.7+/-0.7 for KTP laser and 6.2+/-0.9 for EC treatment (p=.05). Patient-rated mean clinical efficacy of KTP laser was 8.3+/-0.6 and of EC was 7.3+/-0.7 (p=.09). Stratification for potential confounding bias, such as location of SN, central bulging vein, and diameter (p=.25) of the treated SN did not reveal any statistically significant differences between the treatments. Treatment with KTP or EC did not result in scarring or pigmentary changes. Pain was reported for KTP treatment (3.1+/-0.4) and EC (6.4+/-0.7) (p<.05). CONCLUSION: Clinical efficacy of KTP laser and EC for SN is comparable, although there is a tendency toward an advantage in favor of the KTP laser. KTP laser treatment was less painful.
Subject(s)
Electrocoagulation/methods , Facial Neoplasms/therapy , Lasers, Solid-State/therapeutic use , Low-Level Light Therapy/instrumentation , Nevus, Intradermal/therapy , Skin Neoplasms/therapy , Adult , Aged , Facial Neoplasms/pathology , Female , Follow-Up Studies , Humans , Male , Middle Aged , Nevus, Intradermal/pathology , Patient Satisfaction , Single-Blind Method , Skin Neoplasms/pathology , Thoracic Wall , Treatment OutcomeABSTRACT
A male newborn had a large cerebriform tumor covering his shoulders and almost the entire surface of his back. After exclusion of further abnormalities, the diagnosis of cerebriform intradermal nevus was made. This particular variant of giant melanocytic nevus should always be differentiated from cutis verticis gyrata, if located on the vertex. The clinical manifestation of cerebriform intradermal nevi as giant melanocytic nevi on the back is extremely rare, with only one instance reported to date. Such nevi are a therapeutic challenge, particularly if the skin lesion covers a large surface of the body, as in the patient presented here.
Subject(s)
Nevus, Intradermal/pathology , Skin Neoplasms/pathology , Back , Biopsy, Needle , Humans , Immunohistochemistry , Infant, Newborn , Male , Monitoring, Physiologic/methods , Nevus, Intradermal/congenital , Nevus, Intradermal/therapy , Nevus, Pigmented/congenital , Nevus, Pigmented/pathology , Nevus, Pigmented/therapy , Prognosis , Risk Assessment , Skin Neoplasms/congenital , Skin Neoplasms/therapySubject(s)
Electrocoagulation/methods , Facial Neoplasms/therapy , Lasers, Solid-State/therapeutic use , Low-Level Light Therapy/instrumentation , Nevus, Intradermal/therapy , Skin Neoplasms/therapy , Facial Neoplasms/pathology , Humans , Nevus, Intradermal/pathology , Skin Neoplasms/pathology , Thoracic Wall , Treatment OutcomeABSTRACT
Cerebriform intradermal nevus is a rare form of cutis verticis gyrata. Clinically it manifests as a scalp deformity resembling the surface of the brain, with cerebriform morphologic characteristics. Degeneration into malignant melanoma has been reported. Herein, a cerebriform intradermal nevus of the scalp in a 7-year-old girl is reported. The clinical and histopathologic presentations of cerebriform intradermal nevus are described and the therapeutic possibilities discussed.
Subject(s)
Head and Neck Neoplasms/pathology , Nevus, Intradermal/pathology , Scalp , Skin Neoplasms/pathology , Child , Female , Head and Neck Neoplasms/metabolism , Head and Neck Neoplasms/therapy , Humans , Nevus, Intradermal/metabolism , Nevus, Intradermal/therapy , Proliferating Cell Nuclear Antigen/metabolism , Skin Neoplasms/metabolism , Skin Neoplasms/therapy , Tumor Suppressor Protein p53/metabolismABSTRACT
Porokeratotic eccrine ostial and dermal duct nevus is a rare disorder characterized by distinctive histopathology. We describe a 6-year-old boy who had the typical palmar involvement and small discrete areas involving the midline of his back.
Subject(s)
Eccrine Glands , Nevus, Intradermal/pathology , Porokeratosis/pathology , Skin Neoplasms/pathology , Child , Hand , Humans , Male , Nevus, Intradermal/therapy , Porokeratosis/therapy , Skin Neoplasms/therapyABSTRACT
Epidermal naevus syndrome was first described by Solomon et al. in 1968, based on a study of 12 patients. Herein we report the case of a 20-year-old female diagnosed with epidermal naevus syndrome at the age of 3 years. Subsequently she experienced several different symptoms and at the last exploration a suspicious lesion was found in her bladder. The definitive pathology diagnosis was transitional cell carcinoma of the bladder, which is extremely rare in patients aged <21 years. It seems that this neoplastic lesion was directly related to the essential pathology of the patient, namely epidermal naevus syndrome.