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1.

Effect of pre-intercalation on Li-ion diffusion mapped by topochemical single-crystal transformation and operando investigation.

Luo, Yuting; Handy, Joseph V; Das, Tisita; Ponis, John D; Albers, Ryan; Chiang, Yu-Hsiang; Pharr, Matt; Schultz, Brian J; Gobbato, Leonardo; Brown, Dean C; Chakraborty, Sudip; Banerjee, Sarbajit.

Nat Mater ; 2024 Mar 21.

Artículo en Inglés | MEDLINE | ID: mdl-38514846

2.

Analysis of orphan designation status for FDA approved drugs, and case studies in oncology, neuroscience and metabolic diseases.

Brown, Dean G; Wobst, Heike J.

Bioorg Med Chem ; 80: 117170, 2023 02 15.

Artículo en Inglés | MEDLINE | ID: mdl-36696875

3.

Structural insight into allosteric modulation of protease-activated receptor 2.

Cheng, Robert K Y; Fiez-Vandal, Cédric; Schlenker, Oliver; Edman, Karl; Aggeler, Birte; Brown, Dean G; Brown, Giles A; Cooke, Robert M; Dumelin, Christoph E; Doré, Andrew S; Geschwindner, Stefan; Grebner, Christoph; Hermansson, Nils-Olov; Jazayeri, Ali; Johansson, Patrik; Leong, Louis; Prihandoko, Rudi; Rappas, Mathieu; Soutter, Holly; Snijder, Arjan; Sundström, Linda; Tehan, Benjamin; Thornton, Peter; Troast, Dawn; Wiggin, Giselle; Zhukov, Andrei; Marshall, Fiona H; Dekker, Niek.

Nature ; 545(7652): 112-115, 2017 05 04.

Artículo en Inglés | MEDLINE | ID: mdl-28445455

4.

A survey of the clinical pipeline in neuroscience.

Brown, Dean G; Wobst, Heike J.

Bioorg Med Chem Lett ; 56: 128482, 2022 01 15.

Artículo en Inglés | MEDLINE | ID: mdl-34864194

5.

The clinical trial landscape in amyotrophic lateral sclerosis-Past, present, and future.

Wobst, Heike J; Mack, Korrie L; Brown, Dean G; Brandon, Nicholas J; Shorter, James.

Med Res Rev ; 40(4): 1352-1384, 2020 07.

Artículo en Inglés | MEDLINE | ID: mdl-32043626

6.

Emerging small-molecule therapeutic approaches for amyotrophic lateral sclerosis and frontotemporal dementia.

Brown, Dean G; Shorter, James; Wobst, Heike J.

Bioorg Med Chem Lett ; 30(4): 126942, 2020 02 15.

Artículo en Inglés | MEDLINE | ID: mdl-31926785

7.

Tool inhibitors and assays to interrogate the biology of the TRAF2 and NCK interacting kinase.

Read, Jon; Collie, Iain T; Nguyen-McCarty, Michelle; Lucaj, Christopher; Robinson, James; Conway, Leslie; Mukherjee, Jayanta; McCall, Eileen; Donohoe, Gerard; Flavell, Elizabeth; Peciak, Karolina; Warwicker, Juli; Dix, Carly; Van den Hoven, Bernard G; Madin, Andrew; Brown, Dean G; Moss, Stephen; Haggarty, Stephen J; Brandon, Nicholas J; Bürli, Roland W.

Bioorg Med Chem Lett ; 29(15): 1962-1967, 2019 08 01.

Artículo en Inglés | MEDLINE | ID: mdl-31153805

8.

Lasing of surface-polished polycrystalline Ho: YAG (yttrium aluminum garnet) fiber.

Kim, Hyunjun; Hay, Randall S; McDaniel, Sean A; Cook, Gary; Usechak, Nicholas G; Urbas, Augustine M; Shugart, Kathleen N; Lee, HeeDong; Kadhim, Ali H; Brown, Dean P; Griffin, Benjamin; Fair, Geoff E; Corns, Randall G; Potticary, Santeri A; Hopkins, Frank K; Averett, Kent L; Zelmon, David E; Parthasarathy, Triplicane A; Keller, Kristin A.

Opt Express ; 25(6): 6725-6731, 2017 Mar 20.

Artículo en Inglés | MEDLINE | ID: mdl-28381016

9.

Design and synthesis of peptide-based macrocyclic cyclophilin inhibitors.

Granger, Brett A; Brown, Dean G.

Bioorg Med Chem Lett ; 26(21): 5304-5307, 2016 11 01.

Artículo en Inglés | MEDLINE | ID: mdl-27687672

10.

Drug discovery strategies to outer membrane targets in Gram-negative pathogens.

Brown, Dean G.

Bioorg Med Chem ; 24(24): 6320-6331, 2016 12 15.

Artículo en Inglés | MEDLINE | ID: mdl-27178386

11.

Nonlinear chiro-optical amplification by plasmonic nanolens arrays formed via directed assembly of gold nanoparticles.

Biswas, Sushmita; Liu, Xiaoying; Jarrett, Jeremy W; Brown, Dean; Pustovit, Vitaliy; Urbas, Augustine; Knappenberger, Kenneth L; Nealey, Paul F; Vaia, Richard A.

Nano Lett ; 15(3): 1836-42, 2015 Mar 11.

Artículo en Inglés | MEDLINE | ID: mdl-25646978

12.

Novel antibacterial targets and compounds revealed by a high-throughput cell wall reporter assay.

Nayar, Asha S; Dougherty, Thomas J; Ferguson, Keith E; Granger, Brett A; McWilliams, Lisa; Stacey, Clare; Leach, Lindsey J; Narita, Shin-Ichiro; Tokuda, Hajime; Miller, Alita A; Brown, Dean G; McLeod, Sarah M.

J Bacteriol ; 197(10): 1726-34, 2015 May.

Artículo en Inglés | MEDLINE | ID: mdl-25733621

13.

New natural products as new leads for antibacterial drug discovery.

Brown, Dean G; Lister, Troy; May-Dracka, Tricia L.

Bioorg Med Chem Lett ; 24(2): 413-8, 2014 Jan 15.

Artículo en Inglés | MEDLINE | ID: mdl-24388805

14.

A Drug Discovery Perspective on FDA Expedited Development and Incentive Programs.

Brown, Dean G.

J Med Chem ; 67(3): 1690-1700, 2024 Feb 08.

Artículo en Inglés | MEDLINE | ID: mdl-38233132

15.

Forward and backward unidirectional scattering from plasmonic coupled wires.

Poutrina, Ekaterina; Rose, Alec; Brown, Dean; Urbas, Augustine; Smith, David R.

Opt Express ; 21(25): 31138-54, 2013 Dec 16.

Artículo en Inglés | MEDLINE | ID: mdl-24514688

16.

Discovery of a potent respiratory syncytial virus RNA polymerase inhibitor.

Xiong, Hui; Foulk, Melinda; Aschenbrenner, Lisa; Fan, Jun; Tiong-Yip, Choi-Lai; Johnson, Kenneth D; Moustakas, Demetri; Fleming, Paul R; Brown, Dean G; Zhang, Minli; Ferguson, Douglas; Wu, Dedong; Yu, Qin.

Bioorg Med Chem Lett ; 23(24): 6789-93, 2013 Dec 15.

Artículo en Inglés | MEDLINE | ID: mdl-24211022

17.

An Analysis of Successful Hit-to-Clinical Candidate Pairs.

Brown, Dean G.

J Med Chem ; 66(11): 7101-7139, 2023 06 08.

Artículo en Inglés | MEDLINE | ID: mdl-37224022

18.

Fragment-Based Screening Identifies New Quinazolinone-Based Inositol Hexakisphosphate Kinase (IP6K) Inhibitors.

Heitmann, Tyler; Liao, Gangling; de León, Pablo; Ernst, Glen; Buchler, Ingrid; Wei, Huijun; Shlevkov, Evgeny; Brown, Dean; Fitzek, Martina; Collier, Matthew; Smith, David M; Barrow, James C.

ACS Med Chem Lett ; 14(12): 1760-1766, 2023 Dec 14.

Artículo en Inglés | MEDLINE | ID: mdl-38116421

19.

Direct measurement of group delay dispersion in metamagnetics for ultrafast pulse shaping.

Brown, Dean P; Walker, Mark A; Urbas, Augustine M; Kildishev, Alexander V; Xiao, Shumin; Drachev, Vladimir P.

Opt Express ; 20(21): 23082-7, 2012 Oct 08.

Artículo en Inglés | MEDLINE | ID: mdl-23188272

20.

Discovery of novel positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5).

Varnes, Jeffrey G; Marcus, Andrew P; Mauger, Russell C; Throner, Scott R; Hoesch, Valerie; King, Megan M; Wang, Xia; Sygowski, Linda A; Spear, Nathan; Gadient, Reto; Brown, Dean G; Campbell, James B.

Bioorg Med Chem Lett ; 21(5): 1402-6, 2011 Mar 01.

Artículo en Inglés | MEDLINE | ID: mdl-21295468

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Effect of pre-intercalation on Li-ion diffusion mapped by topochemical single-crystal transformation and operando investigation.

Analysis of orphan designation status for FDA approved drugs, and case studies in oncology, neuroscience and metabolic diseases.

Structural insight into allosteric modulation of protease-activated receptor 2.

A survey of the clinical pipeline in neuroscience.

The clinical trial landscape in amyotrophic lateral sclerosis-Past, present, and future.

Emerging small-molecule therapeutic approaches for amyotrophic lateral sclerosis and frontotemporal dementia.

Tool inhibitors and assays to interrogate the biology of the TRAF2 and NCK interacting kinase.

Lasing of surface-polished polycrystalline Ho: YAG (yttrium aluminum garnet) fiber.

Design and synthesis of peptide-based macrocyclic cyclophilin inhibitors.

Drug discovery strategies to outer membrane targets in Gram-negative pathogens.

Nonlinear chiro-optical amplification by plasmonic nanolens arrays formed via directed assembly of gold nanoparticles.

Novel antibacterial targets and compounds revealed by a high-throughput cell wall reporter assay.

New natural products as new leads for antibacterial drug discovery.

A Drug Discovery Perspective on FDA Expedited Development and Incentive Programs.

Forward and backward unidirectional scattering from plasmonic coupled wires.

Discovery of a potent respiratory syncytial virus RNA polymerase inhibitor.

An Analysis of Successful Hit-to-Clinical Candidate Pairs.

Fragment-Based Screening Identifies New Quinazolinone-Based Inositol Hexakisphosphate Kinase (IP6K) Inhibitors.

Direct measurement of group delay dispersion in metamagnetics for ultrafast pulse shaping.

Discovery of novel positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5).