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1.

NHE3 inhibitor tenapanor maintains intestinal barrier function, decreases visceral hypersensitivity, and attenuates TRPV1 signaling in colonic sensory neurons.

King, Andrew J; Chang, Lin; Li, Qian; Liu, Liansheng; Zhu, Yaohui; Pasricha, Pankaj J; Wang, Ji; Siegel, Matthew; Caldwell, Jeremy S; Edelstein, Susan; Rosenbaum, David P; Kozuka, Kenji.

Am J Physiol Gastrointest Liver Physiol ; 326(5): G543-G554, 2024 May 01.

Artículo en Inglés | MEDLINE | ID: mdl-38252683

2.

Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication.

König, Renate; Zhou, Yingyao; Elleder, Daniel; Diamond, Tracy L; Bonamy, Ghislain M C; Irelan, Jeffrey T; Chiang, Chih-Yuan; Tu, Buu P; De Jesus, Paul D; Lilley, Caroline E; Seidel, Shannon; Opaluch, Amanda M; Caldwell, Jeremy S; Weitzman, Matthew D; Kuhen, Kelli L; Bandyopadhyay, Sourav; Ideker, Trey; Orth, Anthony P; Miraglia, Loren J; Bushman, Frederic D; Young, John A; Chanda, Sumit K.

Cell ; 135(1): 49-60, 2008 Oct 03.

Artículo en Inglés | MEDLINE | ID: mdl-18854154

3.

Intestinal TGR5 agonism improves hepatic steatosis and insulin sensitivity in Western diet-fed mice.

Finn, Patricia D; Rodriguez, David; Kohler, Jill; Jiang, Zhengfeng; Wan, Sindy; Blanco, Erick; King, Andrew J; Chen, Tao; Bell, Noah; Dragoli, Dean; Jacobs, Jeffrey W; Jain, Rakesh; Leadbetter, Michael; Siegel, Matthew; Carreras, Christopher W; Koo-McCoy, Samantha; Shaw, Karen; Le, Cathy; Vanegas, Sandra; Hsu, I-Hsin; Kozuka, Kenji; Okamoto, Keiko; Caldwell, Jeremy S; Lewis, Jason G.

Am J Physiol Gastrointest Liver Physiol ; 316(3): G412-G424, 2019 03 01.

Artículo en Inglés | MEDLINE | ID: mdl-30605011

4.

In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen.

Plouffe, David; Brinker, Achim; McNamara, Case; Henson, Kerstin; Kato, Nobutaka; Kuhen, Kelli; Nagle, Advait; Adrián, Francisco; Matzen, Jason T; Anderson, Paul; Nam, Tae-Gyu; Gray, Nathanael S; Chatterjee, Arnab; Janes, Jeff; Yan, S Frank; Trager, Richard; Caldwell, Jeremy S; Schultz, Peter G; Zhou, Yingyao; Winzeler, Elizabeth A.

Proc Natl Acad Sci U S A ; 105(26): 9059-64, 2008 Jul 01.

Artículo en Inglés | MEDLINE | ID: mdl-18579783

5.

Identification and characterization of a small molecule antagonist of human VPAC(2) receptor.

Chu, Alan; Caldwell, Jeremy S; Chen, Yu Alice.

Mol Pharmacol ; 77(1): 95-101, 2010 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-19854890

6.

Human Cep192 is required for mitotic centrosome and spindle assembly.

Gomez-Ferreria, Maria Ana; Rath, Uttama; Buster, Daniel W; Chanda, Sumit K; Caldwell, Jeremy S; Rines, Daniel R; Sharp, David J.

Curr Biol ; 17(22): 1960-6, 2007 Nov 20.

Artículo en Inglés | MEDLINE | ID: mdl-17980596

7.

An intracellular conformational sensor assay for Abl T315I.

Zhou, Vicki; Gao, Xiaoqi; Han, Shulin; Brinker, Achim; Caldwell, Jeremy S; Gu, Xiang-Ju.

Anal Biochem ; 385(2): 300-8, 2009 Feb 15.

Artículo en Inglés | MEDLINE | ID: mdl-19059193

8.

A time-resolved fluorescence resonance energy transfer-based assay for DEN1 peptidase activity.

Engels, Ingo H; Daguia, Catherine; Huynh, Truc; Urbina, Hugo; Buddenkotte, Jörg; Schumacher, Andrew; Caldwell, Jeremy S; Brinker, Achim.

Anal Biochem ; 390(1): 85-7, 2009 Jul 01.

Artículo en Inglés | MEDLINE | ID: mdl-19328766

9.

Time-resolved fluorescence resonance energy transfer and surface plasmon resonance-based assays for retinoid and transthyretin binding to retinol-binding protein 4.

Sharif, Orzala; Hu, Huiyong; Klock, Heath; Hampton, Eric N; Nigoghossian, Edward; Knuth, Mark W; Matzen, Jason; Anderson, Paul; Trager, Richard; Uno, Tetsuo; Glynne, Richard J; Azarian, Sassan M; Caldwell, Jeremy S; Brinker, Achim.

Anal Biochem ; 392(2): 162-8, 2009 Sep 15.

Artículo en Inglés | MEDLINE | ID: mdl-19482004

10.

Cancer cell-based genomic and small molecule screens.

Caldwell, Jeremy S.

Adv Cancer Res ; 96: 145-73, 2007.

Artículo en Inglés | MEDLINE | ID: mdl-17161679

11.

Evaluation of the Pharmacodynamic Effects of the Potassium Binder RDX7675 in Mice.

Davidson, James P; King, Andrew J; Kumaraswamy, Padmapriya; Caldwell, Jeremy S; Korner, Paul; Blanks, Robert C; Jacobs, Jeffrey W.

J Cardiovasc Pharmacol Ther ; 23(3): 244-253, 2018 05.

Artículo en Inglés | MEDLINE | ID: mdl-29130735

12.

Design of Gut-Restricted Thiazolidine Agonists of G Protein-Coupled Bile Acid Receptor 1 (GPBAR1, TGR5).

Chen, Tao; Reich, Nicholas William; Bell, Noah; Finn, Patricia D; Rodriguez, David; Kohler, Jill; Kozuka, Kenji; He, Limin; Spencer, Andrew G; Charmot, Dominique; Navre, Marc; Carreras, Christopher W; Koo-McCoy, Samantha; Tabora, Jocelyn; Caldwell, Jeremy S; Jacobs, Jeffrey W; Lewis, Jason Gustaf.

J Med Chem ; 61(17): 7589-7613, 2018 09 13.

Artículo en Inglés | MEDLINE | ID: mdl-30141927

13.

Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability.

King, Andrew J; Siegel, Matthew; He, Ying; Nie, Baoming; Wang, Ji; Koo-McCoy, Samantha; Minassian, Natali A; Jafri, Qumber; Pan, Deng; Kohler, Jill; Kumaraswamy, Padmapriya; Kozuka, Kenji; Lewis, Jason G; Dragoli, Dean; Rosenbaum, David P; O'Neill, Debbie; Plain, Allein; Greasley, Peter J; Jönsson-Rylander, Ann-Cathrine; Karlsson, Daniel; Behrendt, Margareta; Strömstedt, Maria; Ryden-Bergsten, Tina; Knöpfel, Thomas; Pastor Arroyo, Eva M; Hernando, Nati; Marks, Joanne; Donowitz, Mark; Wagner, Carsten A; Alexander, R Todd; Caldwell, Jeremy S.

Sci Transl Med ; 10(456)2018 08 29.

Artículo en Inglés | MEDLINE | ID: mdl-30158152

14.

Identification of homeodomain proteins, PBX1 and PREP1, involved in the transcription of murine leukemia virus.

Chao, Sheng-Hao; Walker, John R; Chanda, Sumit K; Gray, Nathanael S; Caldwell, Jeremy S.

Mol Cell Biol ; 23(3): 831-41, 2003 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-12529389

15.

Development and Characterization of a Human and Mouse Intestinal Epithelial Cell Monolayer Platform.

Kozuka, Kenji; He, Ying; Koo-McCoy, Samantha; Kumaraswamy, Padmapriya; Nie, Baoming; Shaw, Karen; Chan, Priscilla; Leadbetter, Michael; He, Limin; Lewis, Jason G; Zhong, Ziyang; Charmot, Dominique; Balaa, Marwan; King, Andrew J; Caldwell, Jeremy S; Siegel, Matthew.

Stem Cell Reports ; 9(6): 1976-1990, 2017 12 12.

Artículo en Inglés | MEDLINE | ID: mdl-29153987

16.

Ontology recapitulates physiology.

Caldwell, Jeremy S.

Chem Biol ; 10(9): 784-6, 2003 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-14522048

17.

Fulfilling the promise: drug discovery in the post-genomic era.

Chanda, Sumit K; Caldwell, Jeremy S.

Drug Discov Today ; 8(4): 168-74, 2003 Feb 15.

Artículo en Inglés | MEDLINE | ID: mdl-12581711

18.

Enhanced expression of nicotinamide N-methyltransferase in human papillary thyroid carcinoma cells.

Xu, Jimin; Moatamed, Farhad; Caldwell, Jeremy S; Walker, John R; Kraiem, Zaki; Taki, Katsumi; Brent, Gregory A; Hershman, Jerome M.

J Clin Endocrinol Metab ; 88(10): 4990-6, 2003 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-14557485

19.

An interview with Jeremy S. Caldwell.

Caldwell, Jeremy S.

Assay Drug Dev Technol ; 6(3): 299-306, 2008 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-18593374

20.

Parsimonious discovery of synergistic drug combinations.

Severyn, Bryan; Liehr, Robert A; Wolicki, Alex; Nguyen, Kevin H; Hudak, Edward M; Ferrer, Marc; Caldwell, Jeremy S; Hermes, Jeffrey D; Li, Jing; Tudor, Matthew.

ACS Chem Biol ; 6(12): 1391-8, 2011 Dec 16.

Artículo en Inglés | MEDLINE | ID: mdl-21974780

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NHE3 inhibitor tenapanor maintains intestinal barrier function, decreases visceral hypersensitivity, and attenuates TRPV1 signaling in colonic sensory neurons.

Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication.

Intestinal TGR5 agonism improves hepatic steatosis and insulin sensitivity in Western diet-fed mice.

In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen.

Identification and characterization of a small molecule antagonist of human VPAC(2) receptor.

Human Cep192 is required for mitotic centrosome and spindle assembly.

An intracellular conformational sensor assay for Abl T315I.

A time-resolved fluorescence resonance energy transfer-based assay for DEN1 peptidase activity.

Time-resolved fluorescence resonance energy transfer and surface plasmon resonance-based assays for retinoid and transthyretin binding to retinol-binding protein 4.

Cancer cell-based genomic and small molecule screens.

Evaluation of the Pharmacodynamic Effects of the Potassium Binder RDX7675 in Mice.

Design of Gut-Restricted Thiazolidine Agonists of G Protein-Coupled Bile Acid Receptor 1 (GPBAR1, TGR5).

Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability.

Identification of homeodomain proteins, PBX1 and PREP1, involved in the transcription of murine leukemia virus.

Development and Characterization of a Human and Mouse Intestinal Epithelial Cell Monolayer Platform.

Ontology recapitulates physiology.

Fulfilling the promise: drug discovery in the post-genomic era.

Enhanced expression of nicotinamide N-methyltransferase in human papillary thyroid carcinoma cells.

An interview with Jeremy S. Caldwell.

Parsimonious discovery of synergistic drug combinations.