RESUMEN
Chemical investigations of the crude MeOH extract of Physalis viscosa led to the identification of the novel acylated sucrose ester physaloside A (1). The structure of 1 was determined by 2D NMR analysis, and the absolute configuration was determined by chemical degradation and comparison with authentic standards.
Asunto(s)
Bacterias Grampositivas/efectos de los fármacos , Physalis/química , Plantas Medicinales/química , Sacarosa , Sacarosa/análogos & derivados , Sacarosa/aislamiento & purificación , Australia , Ensayos de Selección de Medicamentos Antitumorales , Ésteres/química , Ésteres/aislamiento & purificación , Ésteres/farmacología , Pruebas de Sensibilidad Microbiana , Estructura Molecular , Resonancia Magnética Nuclear Biomolecular , Sacarosa/química , Sacarosa/farmacologíaRESUMEN
To new triterpenes, trichomycins A (1) and B (2), were purified from the new species Tricholoma sp. AU1 by activity-guided fractionation following their antibacterial activity. The two compounds were found to have a hitherto unreported triterpenoid skeleton. The structures and relative stereochemistry of 1 and 2 were determined through extensive 2D NMR spectroscopy, while the inhibitory activity of 1 and 2 against two Gram-positive and two Gram-negative bacteria and a mammalian cell line was determined.