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World Neurosurg ; 139: 419-422, 2020 07.
Artículo en Inglés | MEDLINE | ID: mdl-32360918

RESUMEN

OBJECTIVE: To describe a case of an adult female Filipino with hypereosinophilia and bilateral carotid artery aneurysms who subsequently developed bilateral cerebral hemisphere strokes following aneurysm stenting. CASE DESCRIPTION: A 57-year-old female patient with persistent hypereosinophilia presented with progressively enlarging bilateral neck masses, revealed to be carotid artery aneurysms on computed tomography angiography. Following surgical exploration, she later developed right-sided hemiplegia, aphasia, and right hemianopia. Cranial computed tomography revealed infarcts on both middle cerebral artery territories. Bone marrow biopsy and fluorescent in situ hybridization revealed findings suggestive of hypereosinophilic syndrome. She was started on standard aspirin and statin therapy and was discharged sixteen days after the procedure. Partial improvement of neurologic deficits was noted two months later on follow up. Chemotherapy with imatinib was initiated. CONCLUSIONS: This patient's prothrombotic state from FIP1L1-PDGFRA-positive hypereosinophilia may have led to large carotid artery aneurysm formation and intramural thrombosis. This case demonstrates a possible and heretofore undocumented neurovascular sequela of hypereosinophilic syndrome.


Asunto(s)
Aneurisma/complicaciones , Procedimientos Endovasculares/efectos adversos , Síndrome Hipereosinofílico/complicaciones , Complicaciones Posoperatorias/etiología , Accidente Cerebrovascular/etiología , Aneurisma/cirugía , Enfermedades de las Arterias Carótidas/complicaciones , Enfermedades de las Arterias Carótidas/cirugía , Arteria Carótida Interna/patología , Arteria Carótida Interna/cirugía , Femenino , Humanos , Síndrome Hipereosinofílico/genética , Persona de Mediana Edad , Proteínas de Fusión Oncogénica , Receptor alfa de Factor de Crecimiento Derivado de Plaquetas , Stents , Factores de Escisión y Poliadenilación de ARNm
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