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1.

Structure of detergent-activated BAK dimers derived from the inert monomer.

Birkinshaw, Richard W; Iyer, Sweta; Lio, Daisy; Luo, Cindy S; Brouwer, Jason M; Miller, Michelle S; Robin, Adeline Y; Uren, Rachel T; Dewson, Grant; Kluck, Ruth M; Colman, Peter M; Czabotar, Peter E.

Mol Cell ; 81(10): 2123-2134.e5, 2021 05 20.

Artículo en Inglés | MEDLINE | ID: mdl-33794146

2.

Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis.

Czabotar, Peter E; Westphal, Dana; Dewson, Grant; Ma, Stephen; Hockings, Colin; Fairlie, W Douglas; Lee, Erinna F; Yao, Shenggen; Robin, Adeline Y; Smith, Brian J; Huang, David C S; Kluck, Ruth M; Adams, Jerry M; Colman, Peter M.

Cell ; 152(3): 519-31, 2013 Jan 31.

Artículo en Inglés | MEDLINE | ID: mdl-23374347

3.

Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.

Brouwer, Jason M; Lan, Ping; Cowan, Angus D; Bernardini, Jonathan P; Birkinshaw, Richard W; van Delft, Mark F; Sleebs, Brad E; Robin, Adeline Y; Wardak, Ahmad; Tan, Iris K; Reljic, Boris; Lee, Erinna F; Fairlie, W Douglas; Call, Melissa J; Smith, Brian J; Dewson, Grant; Lessene, Guillaume; Colman, Peter M; Czabotar, Peter E.

Mol Cell ; 68(4): 659-672.e9, 2017 Nov 16.

Artículo en Inglés | MEDLINE | ID: mdl-29149594

4.

New antivirals and drug resistance.

Colman, Peter M.

Annu Rev Biochem ; 78: 95-118, 2009.

Artículo en Inglés | MEDLINE | ID: mdl-19254207

5.

Physiological restraint of Bak by Bcl-xL is essential for cell survival.

Lee, Erinna F; Grabow, Stephanie; Chappaz, Stephane; Dewson, Grant; Hockings, Colin; Kluck, Ruth M; Debrincat, Marlyse A; Gray, Daniel H; Witkowski, Matthew T; Evangelista, Marco; Pettikiriarachchi, Anne; Bouillet, Philippe; Lane, Rachael M; Czabotar, Peter E; Colman, Peter M; Smith, Brian J; Kile, Benjamin T; Fairlie, W Douglas.

Genes Dev ; 30(10): 1240-50, 2016 05 15.

Artículo en Inglés | MEDLINE | ID: mdl-27198225

6.

The Bak core dimer focuses triacylglycerides in the membrane.

Smith, Nicholas A; Wardak, Ahmad Z; Cowan, Angus D; Colman, Peter M; Czabotar, Peter E; Smith, Brian J.

Biophys J ; 121(3): 347-360, 2022 02 01.

Artículo en Inglés | MEDLINE | ID: mdl-34973947

7.

Bak core and latch domains separate during activation, and freed core domains form symmetric homodimers.

Brouwer, Jason M; Westphal, Dana; Dewson, Grant; Robin, Adeline Y; Uren, Rachel T; Bartolo, Ray; Thompson, Geoff V; Colman, Peter M; Kluck, Ruth M; Czabotar, Peter E.

Mol Cell ; 55(6): 938-946, 2014 Sep 18.

Artículo en Inglés | MEDLINE | ID: mdl-25175025

8.

A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis.

van Delft, Mark F; Chappaz, Stephane; Khakham, Yelena; Bui, Chinh T; Debrincat, Marlyse A; Lowes, Kym N; Brouwer, Jason M; Grohmann, Christoph; Sharp, Phillip P; Dagley, Laura F; Li, Lucy; McArthur, Kate; Luo, Meng-Xiao; Chin, Hui San; Fairlie, W Douglas; Lee, Erinna F; Segal, David; Duflocq, Stephane; Lessene, Romina; Bernard, Sabrina; Peilleron, Laure; Nguyen, Thao; Miles, Caroline; Wan, Soo San; Lane, Rachael M; Wardak, Ahmad; Lackovic, Kurt; Colman, Peter M; Sandow, Jarrod J; Webb, Andrew I; Czabotar, Peter E; Dewson, Grant; Watson, Keith G; Huang, David C S; Lessene, Guillaume; Kile, Benjamin T.

Nat Chem Biol ; 15(11): 1057-1066, 2019 11.

Artículo en Inglés | MEDLINE | ID: mdl-31591564

9.

The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments.

Zhang, Jian-Guo; Czabotar, Peter E; Policheni, Antonia N; Caminschi, Irina; Wan, Soo San; Kitsoulis, Susie; Tullett, Kirsteen M; Robin, Adeline Y; Brammananth, Rajini; van Delft, Mark F; Lu, Jinhua; O'Reilly, Lorraine A; Josefsson, Emma C; Kile, Benjamin T; Chin, Wei Jin; Mintern, Justine D; Olshina, Maya A; Wong, Wilson; Baum, Jake; Wright, Mark D; Huang, David C S; Mohandas, Narla; Coppel, Ross L; Colman, Peter M; Nicola, Nicos A; Shortman, Ken; Lahoud, Mireille H.

Immunity ; 36(4): 646-57, 2012 Apr 20.

Artículo en Inglés | MEDLINE | ID: mdl-22483802

10.

To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions.

Dewson, Grant; Kratina, Tobias; Sim, Huiyan W; Puthalakath, Hamsa; Adams, Jerry M; Colman, Peter M; Kluck, Ruth M.

Mol Cell ; 30(3): 369-80, 2008 May 09.

Artículo en Inglés | MEDLINE | ID: mdl-18471982

11.

The functional differences between pro-survival and pro-apoptotic B cell lymphoma 2 (Bcl-2) proteins depend on structural differences in their Bcl-2 homology 3 (BH3) domains.

Lee, Erinna F; Dewson, Grant; Evangelista, Marco; Pettikiriarachchi, Anne; Gold, Grace J; Zhu, Haoran; Colman, Peter M; Fairlie, W Douglas.

J Biol Chem ; 289(52): 36001-17, 2014 Dec 26.

Artículo en Inglés | MEDLINE | ID: mdl-25371206

12.

Structural insight into BH3 domain binding of vaccinia virus antiapoptotic F1L.

Campbell, Stephanie; Thibault, John; Mehta, Ninad; Colman, Peter M; Barry, Michele; Kvansakul, Marc.

J Virol ; 88(15): 8667-77, 2014 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-24850748

13.

Structure-guided design of a selective BCL-X(L) inhibitor.

Lessene, Guillaume; Czabotar, Peter E; Sleebs, Brad E; Zobel, Kerry; Lowes, Kym N; Adams, Jerry M; Baell, Jonathan B; Colman, Peter M; Deshayes, Kurt; Fairbrother, Wayne J; Flygare, John A; Gibbons, Paul; Kersten, Wilhelmus J A; Kulasegaram, Sanji; Moss, Rebecca M; Parisot, John P; Smith, Brian J; Street, Ian P; Yang, Hong; Huang, David C S; Watson, Keith G.

Nat Chem Biol ; 9(6): 390-7, 2013 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-23603658

14.

NMR studies of interactions between Bax and BH3 domain-containing peptides in the absence and presence of CHAPS.

Yao, Shenggen; Westphal, Dana; Babon, Jeffrey J; Thompson, Geoff V; Robin, Adeline Y; Adams, Jerry M; Colman, Peter M; Czabotar, Peter E.

Arch Biochem Biophys ; 545: 33-43, 2014 Mar 01.

Artículo en Inglés | MEDLINE | ID: mdl-24434006

15.

Discovery and molecular characterization of a Bcl-2-regulated cell death pathway in schistosomes.

Lee, Erinna F; Clarke, Oliver B; Evangelista, Marco; Feng, Zhiping; Speed, Terence P; Tchoubrieva, Elissaveta B; Strasser, Andreas; Kalinna, Bernd H; Colman, Peter M; Fairlie, W Douglas.

Proc Natl Acad Sci U S A ; 108(17): 6999-7003, 2011 Apr 26.

Artículo en Inglés | MEDLINE | ID: mdl-21444803

16.

Sheeppox virus SPPV14 encodes a Bcl-2-like cell death inhibitor that counters a distinct set of mammalian proapoptotic proteins.

Okamoto, Toru; Campbell, Stephanie; Mehta, Ninad; Thibault, John; Colman, Peter M; Barry, Michele; Huang, David C S; Kvansakul, Marc.

J Virol ; 86(21): 11501-11, 2012 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-22896610

17.

Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids.

Miller, Michelle S; Cowan, Angus D; Brouwer, Jason M; Smyth, Sean T; Peng, Liuyu; Wardak, Ahmad Z; Uren, Rachel T; Luo, Cindy; Roy, Michael J; Shah, Sayali; Tan, Ziwen; Reid, Gavin E; Colman, Peter M; Czabotar, Peter E.

FEBS J ; 2023 Dec 13.

Artículo en Inglés | MEDLINE | ID: mdl-38088212

18.

Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis.

Czabotar, Peter E; Lee, Erinna F; Thompson, Geoff V; Wardak, Ahmad Z; Fairlie, W Douglas; Colman, Peter M.

J Biol Chem ; 286(9): 7123-31, 2011 Mar 04.

Artículo en Inglés | MEDLINE | ID: mdl-21199865

19.

Evaluation of diverse α/ß-backbone patterns for functional α-helix mimicry: analogues of the Bim BH3 domain.

Boersma, Melissa D; Haase, Holly S; Peterson-Kaufman, Kimberly J; Lee, Erinna F; Clarke, Oliver B; Colman, Peter M; Smith, Brian J; Horne, W Seth; Fairlie, W Douglas; Gellman, Samuel H.

J Am Chem Soc ; 134(1): 315-23, 2012 Jan 11.

Artículo en Inglés | MEDLINE | ID: mdl-22040025

20.

Structural basis for apoptosis inhibition by Epstein-Barr virus BHRF1.

Kvansakul, Marc; Wei, Andrew H; Fletcher, Jamie I; Willis, Simon N; Chen, Lin; Roberts, Andrew W; Huang, David C S; Colman, Peter M.

PLoS Pathog ; 6(12): e1001236, 2010 Dec 23.

Artículo en Inglés | MEDLINE | ID: mdl-21203485

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