[Reversibility of hepatitis B virus-induced liver cirrhosis after prolonged antiviral therapy]. / Desaparición de cirrosis hepática por VHB tras tratamiento prolongado con antivirales.

Reversibility of liver fibrosis or cirrhosis involves complete restoration of normal liver architecture. This phenomenon has been well documented in chronic liver diseases such as autoimmune hepatitis, biliary obstruction, hemochromatosis, nonalcoholic steatohepatitis, and viral hepatitis. There are very few reports of reversal of cirrhosis after antiviral therapy in patients with chronic hepatitis B virus (HBV) infection. We report a case of disappearance of HBV-induced liver cirrhosis after years of treatment with distinct antiviral drugs, documented by successive biopsy results. This disappearance was accompanied by normalization of platelet count, gammaglobulin titers, and radiologic findings.

Desaparición de cirrosis hepática por VHB tras tratamiento prolongado con antivirales / Reversibility of hepatitis B virus-induced liver cirrhosis after prolonged antiviral therapy

ResumenLa reversibilidad de la fibrosis o cirrosis hepática implica la restauración completa de la arquitectura normal del hígado. Este hecho ha sido bien documentado en algunas enfermedades crónicas hepáticas como hepatitis autoinmune, obstrucción biliar, hemocromatosis, esteatohepatitis no alcohólica y en hepatitis virales. En la literatura se han descrito muy pocos casos de reversión de cirrosis tras tratamiento antiviral en pacientes con infección crónica por VHB.ResumenDescribimos un caso de desaparición de cirrosis hepática por VHB tras años de tratamiento con distintos antivirales, y que se ha podido documentar mediante sucesivas biopsias hepáticas. Además se ha acompañado de normalización de cifra de plaquetas, gammglobulina y las imágenes radiológicas (AU)

AbstractReversibility of liver fibrosis or cirrhosis involves complete restoration of normal liver architecture. This phenomenon has been well documented in chronic liver diseases such as autoimmune hepatitis, biliary obstruction, hemochromatosis, nonalcoholic steatohepatitis, and viral hepatitis. There are very few reports of reversal of cirrhosis after antiviral therapy in patients with chronic hepatitis B virus (HBV) infection.AbstractWe report a case of disappearance of HBV-induced liver cirrhosis after years of treatment with distinct antiviral drugs, documented by successive biopsy results. This disappearance was accompanied by normalization of platelet count, gammaglobulin titers, and radiologic findings (AU)