Interpretable CNN for ischemic stroke subtype classification with active model adaptation.

BACKGROUND: TOAST subtype classification is important for diagnosis and research of ischemic stroke. Limited by experience of neurologist and time-consuming manual adjudication, it is a big challenge to finish TOAST classification effectively. We propose a novel active deep learning architecture to classify TOAST. METHODS: To simulate the diagnosis process of neurologists, we drop the valueless features by XGB algorithm and rank the remaining ones. Utilizing active learning framework, we propose a novel causal CNN, in which it combines with a mixed active selection criterion to optimize the uncertainty of samples adaptively. Meanwhile, KL-focal loss derived from the enhancement of Focal loss by KL regularization is introduced to accelerate the iterative fine-tuning of the model. RESULTS: To evaluate the proposed method, we construct a dataset which consists of totally 2310 patients. In a series of sequential experiments, we verify the effectiveness of each contribution by different evaluation metrics. Experimental results show that the proposed method achieves competitive results on each evaluation metric. In this task, the improvement of AUC is the most obvious, reaching 77.4. CONCLUSIONS: We construct a backbone causal CNN to simulate the neurologist process of that could enhance the internal interpretability. The research on clinical data also indicates the potential application value of this model in stroke medicine. Future work we would consider various data types and more comprehensive patient types to achieve fully automated subtype classification.

An effective feature extraction method based on GDS for atrial fibrillation detection.

Atrial fibrillation (AF) is a common and extremely harmful arrhythmia disease. Automatic detection of AF based on ECG helps accurate and timely detection of the condition. However, the existing AF detection methods are mostly based on complex signal transformation or precise waveform localization. This is a big challenge for complex, variable, and susceptible ECG signals. Therefore, we propose a simple feature extraction method based on gradient set (GDS) for AF detection. The method first calculates the GDS of the ECG segment and then calculates the statistical distribution feature and the information quantity feature of the GDS as the input of the classifier. Experiments on four databases include 146 subjects show that the feature extraction method for detecting AF proposed in this paper has the characteristics of simple calculation, noise tolerance, and high adaptability to all kinds of classifiers, and got the best performance on the DNN classifier we designed. Therefore, it is a good choice for feature extraction in AF detection.

RISE-based adaptive tracking control for Euler-Lagrange mechanical systems with matched disturbances.

The core idea of traditional adaptive control is to reconstruct parameter estimation errors with known signals and damping injection based on tracking error, while the formulation of desired damping in controller designs is usually a nontrivial task. The main contribution of this paper lies in the development of the classic RISE result and a constructive damping injection procedure for the adaptive tracking control of Euler-Lagrange mechanical systems. By utilizing generalized dynamic scaling function, scalar filtering, the improved RISE method and analyzing the existence of finite escape time of the closed-loop system, a globally asymptotically stable result is obtained with facilitative damping injection, significant order reduction and improved design efficiency when compared with the existing results. Simulations on a fully actuated 2-DOF planar robot manipulator model demonstrate the effectiveness of the proposed methods.

Finite-time controller design with adaptive fixed-time anti-saturation compensator for hypersonic vehicle.

An adaptive anti-saturation robust finite-time control algorithm (AARFTC) is designed for flexible air-breathing hypersonic vehicle (FAHV) under actuator saturations. Firstly, an adaptive fixed-time anti-saturation compensator (AFAC) is presented to drive system to faster leave the saturated region Compared to traditional anti-saturation compensators, the auxiliary variable of AFAC is able to realize faster and more accurate convergence when saturation disappears, which avoids the influence on convergent characteristics of tracking error. In addition, the novel adaptive law in AFAC can further shorten the duration of saturation and improve the convergent speed of tracking error via adjusting gain in AFAC according to saturation of actuator. Then, dynamic inversion control is combined with AFAC to establish anti-saturation controller for velocity subsystem. Secondly, differentiator-based backstepping control is combined with AFAC for height subsystem. Two recursive fixed settling time differentiators are utilized to approximate derivatives of virtual control signals exactly in fixed time, which avoids the complex computational burden residing in traditional backstepping control and improves convergent accuracy compared to command filtered backstepping control. Meanwhile, AFAC is utilized to suppress the influence of elevator saturation. Ultimately, multiple sets of simulations on FAHV subject to external disturbances, parametric uncertainties and actuator saturations are carried out to show the superiorities of AFAC and AARFTC.

Interpretability Analysis of One-Year Mortality Prediction for Stroke Patients Based on Deep Neural Network.

Clinically, physicians collect the benchmark medical data to establish archives for a stroke patient and then add the follow up data regularly. It has great significance on prognosis prediction for stroke patients. In this paper, we present an interpretable deep learning model to predict the one-year mortality risk on stroke. We design sub-modules to reconstruct features from original clinical data that highlight the dissimilarity and temporality of different variables. The model consists of Bidirectional Long Short-Term Memory (Bi-LSTM), in which a novel correlation attention module is proposed that takes the correlation of variables into consideration. In experiments, datasets are collected clinically from the department of neurology in a local AAA hospital. It consists of 2,275 stroke patients hospitalized in the department of neurology from 2014 to 2016. Our model achieves a precision of 0.9414, a recall of 0.9502 and an F1-score of 0.9415. In addition, we provide the analysis of the interpretability by visualizations with reference to clinical professional guidelines.

SS-SWT and SI-CNN: An Atrial Fibrillation Detection Framework for Time-Frequency ECG Signal.

Atrial fibrillation is the most common arrhythmia and is associated with high morbidity and mortality from stroke, heart failure, myocardial infarction, and cerebral thrombosis. Effective and rapid detection of atrial fibrillation is critical to reducing morbidity and mortality in patients. Screening atrial fibrillation quickly and efficiently remains a challenging task. In this paper, we propose SS-SWT and SI-CNN: an atrial fibrillation detection framework for the time-frequency ECG signal. First, specific-scale stationary wavelet transform (SS-SWT) is used to decompose a 5-s ECG signal into 8 scales. We select specific scales of coefficients as valid time-frequency features and abandon the other coefficients. The selected coefficients are fed to the scale-independent convolutional neural network (SI-CNN) as a two-dimensional (2D) matrix. In SI-CNN, a convolution kernel specifically for the time-frequency characteristics of ECG signals is designed. During the convolution process, the independence between each scale of coefficient is preserved, and the time domain and the frequency domain characteristics of the ECG signal are effectively extracted, and finally the atrial fibrillation signal is quickly and accurately identified. In this study, experiments are performed using the MIT-BIH AFDB data in 5-s data segments. We achieve 99.03% sensitivity, 99.35% specificity, and 99.23% overall accuracy. The SS-SWT and SI-CNN we propose simplify the feature extraction step, effectively extracts the features of ECG, and reduces the feature redundancy that may be caused by wavelet transform. The results shows that the method can effectively detect atrial fibrillation signals and has potential in clinical application.

Learning-Based Adaptive Attitude Control of Spacecraft Formation With Guaranteed Prescribed Performance.

This paper investigates a novel leader-following attitude control approach for spacecraft formation under the preassigned two-layer performance with consideration of unknown inertial parameters, external disturbance torque, and unmodeled uncertainty. First, two-layer prescribed performance is preselected for both the attitude angular and angular velocity tracking errors. Subsequently, a distributed two-layer performance controller is devised, which can guarantee that all the involved closed-loop signals are uniformly ultimately bounded. In order to tackle the defect of statically two-layer performance controller, learning-based control strategy is introduced to serve as an adaptive supplementary controller based on adaptive dynamic programming technique. This enhances the adaptiveness of the statically two-layer performance controller with respect to unexpected uncertainty dramatically, without any prior knowledge of the inertial information. Furthermore, by employing the robustly positively invariant theory, the input-to-state stability is rigorously proven under the designed learning-based distributed controller. Finally, two groups of simulation examples are organized to validate the feasibility and effectiveness of the proposed distributed control approach.

A Classifier Graph Based Recurring Concept Detection and Prediction Approach.

It is common in real-world data streams that previously seen concepts will reappear, which suggests a unique kind of concept drift, known as recurring concepts. Unfortunately, most of existing algorithms do not take full account of this case. Motivated by this challenge, a novel paradigm was proposed for capturing and exploiting recurring concepts in data streams. It not only incorporates a distribution-based change detector for handling concept drift but also captures recurring concept by storing recurring concepts in a classifier graph. The possibility of detecting recurring drifts allows reusing previously learnt models and enhancing the overall learning performance. Extensive experiments on both synthetic and real-world data streams reveal that the approach performs significantly better than the state-of-the-art algorithms, especially when concepts reappear.

Robust inertia-free attitude takeover control of postcapture combined spacecraft with guaranteed prescribed performance.

In this paper, a robust inertia-free attitude takeover control scheme with guaranteed prescribed performance is investigated for postcapture combined spacecraft with consideration of unmeasurable states, unknown inertial property and external disturbance torque. Firstly, to estimate the unavailable angular velocity of combination accurately, a novel finite-time-convergent tracking differentiator is developed with a quite computationally achievable structure free from the unknown nonlinear dynamics of combined spacecraft. Then, a robust inertia-free prescribed performance control scheme is proposed, wherein, the transient and steady-state performance of combined spacecraft is first quantitatively studied by stabilizing the filtered attitude tracking errors. Compared with the existing works, the prominent advantage is that no parameter identifications and no neural or fuzzy nonlinear approximations are needed, which decreases the complexity of robust controller design dramatically. Moreover, the prescribed performance of combined spacecraft is guaranteed a priori without resorting to repeated regulations of the controller parameters. Finally, four illustrative examples are employed to validate the effectiveness of the proposed control scheme and tracking differentiator.

An image retrieval system based on fractal dimension.

This paper presents a new kind of image retrieval system which obtains the feature vectors of images by estimating their fractal dimension; and at the same time establishes a tree-structure image database. After preprocessing and feature extracting, a given image is matched with the standard images in the image database using a hierarchical method of image indexing.