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1.

Backbone Modification Provides a Long-Acting Inverse Agonist of Pathogenic, Constitutively Active PTH1R Variants.

Liu, Shi; Daley, Eileen J; Tran, Lauren My-Linh; Yu, Zhen; Reyes, Monica; Dean, Thomas; Khatri, Ashok; Levine, Paul M; Balana, Aaron T; Pratt, Matthew R; Jüppner, Harald; Gellman, Samuel H; Gardella, Thomas J.

J Am Chem Soc ; 146(10): 6522-6529, 2024 Mar 13.

Artículo en Inglés | MEDLINE | ID: mdl-38417010

2.

Expanding the role of PSMA PET in active surveillance.

Jain, Anika; Nassour, Anthony-Joe; Dean, Thomas; Patterson, Imogen; Tarlinton, Lisa; Kim, Lawrence; Woo, Henry.

BMC Urol ; 23(1): 77, 2023 Apr 29.

Artículo en Inglés | MEDLINE | ID: mdl-37120544

3.

Isolated late testicular relapse of B-cell acute lymphoblastic leukemia treated with intensive systemic chemotherapy and response-based testicular radiation: A Children's Oncology Group study.

Barredo, Julio C; Hastings, Caroline; Lu, Xiamin; Devidas, Meenakshi; Chen, Yichen; Armstrong, Daniel; Winick, Naomi; Wood, Brent Lee; Yanofsky, Rochelle; Loh, Mignon; Gastier-Foster, Julie M; Jorstad, Dean Thomas; Marcus, Robert; Ritchey, Kim; Carrol, William L; Hunger, Stephen P.

Pediatr Blood Cancer ; 65(5): e26928, 2018 05.

Artículo en Inglés | MEDLINE | ID: mdl-29286562

4.

Critical role of parathyroid hormone (PTH) receptor-1 phosphorylation in regulating acute responses to PTH.

Maeda, Akira; Okazaki, Makoto; Baron, David M; Dean, Thomas; Khatri, Ashok; Mahon, Mathew; Segawa, Hiroko; Abou-Samra, Abdul B; Jüppner, Harald; Bloch, Kenneth D; Potts, John T; Gardella, Thomas J.

Proc Natl Acad Sci U S A ; 110(15): 5864-9, 2013 Apr 09.

Artículo en Inglés | MEDLINE | ID: mdl-23533279

5.

Altered Signaling and Desensitization Responses in PTH1R Mutants Associated with Eiken Syndrome.

Portales-Castillo, Ignacio; Dean, Thomas; Cheloha, Ross W; Creemer, Brendan A; Vilardaga, Jean-Pierre; Savransky, Sofya; Khatri, Ashok; Jüppner, Harald; Gardella, Thomas J.

Commun Biol ; 6(1): 599, 2023 06 02.

Artículo en Inglés | MEDLINE | ID: mdl-37268817

6.

Multiparametric Magnetic Resonance Imaging of the Prostate and Prostate-specific Membrane Positron Emission Tomography Prior to Prostate Biopsy (MP4 Study).

Woo, Henry H; Khanani, Hadia; Thompson, Nadine J; Sorensen, Brian J; Baskaranathan, Sris; Bergersen, Philip; Chalasani, Venu; Dean, Thomas; Dias, Max; Symons, James; Wines, Michael; Jain, Anika; Nassour, Anthony-Joe; Tarlinton, Lisa C.

Eur Urol Open Sci ; 47: 119-125, 2023 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-36601041

7.

Acute down-regulation of sodium-dependent phosphate transporter NPT2a involves predominantly the cAMP/PKA pathway as revealed by signaling-selective parathyroid hormone analogs.

Nagai, So; Okazaki, Makoto; Segawa, Hiroko; Bergwitz, Clemens; Dean, Thomas; Potts, John T; Mahon, Matthew J; Gardella, Thomas J; Jüppner, Harald.

J Biol Chem ; 286(2): 1618-26, 2011 Jan 14.

Artículo en Inglés | MEDLINE | ID: mdl-21047792

8.

Engineering of therapeutic polypeptides through chemical synthesis: early lessons from human parathyroid hormone and analogues.

Dong, Suwei; Shang, Shiying; Li, Jianfeng; Tan, Zhongping; Dean, Thomas; Maeda, Akira; Gardella, Thomas J; Danishefsky, Samuel J.

J Am Chem Soc ; 134(36): 15122-9, 2012 Sep 12.

Artículo en Inglés | MEDLINE | ID: mdl-22891619

9.

Delay in discharge and its impact on unnecessary hospital bed occupancy.

Majeed, Muhammad Umair; Williams, Dean Thomas; Pollock, Rachel; Amir, Farhat; Liam, Martin; Foong, Keen S; Whitaker, Chris J.

BMC Health Serv Res ; 12: 410, 2012 Nov 20.

Artículo en Inglés | MEDLINE | ID: mdl-23167656

10.

Functional Properties of Two Distinct PTH1R Mutants Associated With Either Skeletal Defects or Pseudohypoparathyroidism.

Portales-Castillo, Ignacio; Dean, Thomas; Khatri, Ashok; Jüppner, Harald; Gardella, Thomas J.

JBMR Plus ; 6(6): e10604, 2022 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-35720667

11.

Projecting climate change effects on forest net primary productivity in subtropical Louisiana, USA.

Wang, Fugui; Xu, Y Jun; Dean, Thomas J.

Ambio ; 40(5): 506-20, 2011 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-21848139

12.

Comparable Initial Engagement of Intracellular Signaling Pathways by Parathyroid Hormone Receptor Ligands Teriparatide, Abaloparatide, and Long-Acting PTH.

Sato, Tadatoshi; Verma, Shiv; Khatri, Ashok; Dean, Thomas; Goransson, Olga; Gardella, Thomas J; Wein, Marc N.

JBMR Plus ; 5(5): e10441, 2021 May.

Artículo en Inglés | MEDLINE | ID: mdl-33977197

13.

Ligand-Dependent Effects of Methionine-8 Oxidation in Parathyroid Hormone Peptide Analogues.

Daley, Eileen J; Khatri, Ashok; Dean, Thomas; Vilardaga, Jean-Pierre; Zaidi, Saheem A; Katritch, Vsevolod; Gardella, Thomas J.

Endocrinology ; 162(2)2021 02 01.

Artículo en Inglés | MEDLINE | ID: mdl-33242090

14.

An Inverse Agonist Ligand of the PTH Receptor Partially Rescues Skeletal Defects in a Mouse Model of Jansen's Metaphyseal Chondrodysplasia.

Noda, Hiroshi; Guo, Jun; Khatri, Ashok; Dean, Thomas; Reyes, Monica; Armanini, Michael; Brooks, Daniel J; Martins, Janaina S; Schipani, Ernestina; Bouxsein, Mary L; Demay, Marie B; Potts, John T; Jüppner, Harald; Gardella, Thomas J.

J Bone Miner Res ; 35(3): 540-549, 2020 03.

Artículo en Inglés | MEDLINE | ID: mdl-31693237

15.

Altered selectivity of parathyroid hormone (PTH) and PTH-related protein (PTHrP) for distinct conformations of the PTH/PTHrP receptor.

Dean, Thomas; Vilardaga, Jean-Pierre; Potts, John T; Gardella, Thomas J.

Mol Endocrinol ; 22(1): 156-66, 2008 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-17872377

16.

Mechanisms of ligand binding to the parathyroid hormone (PTH)/PTH-related protein receptor: selectivity of a modified PTH(1-15) radioligand for GalphaS-coupled receptor conformations.

Dean, Thomas; Linglart, Agnes; Mahon, Matthew J; Bastepe, Murat; Jüppner, Harald; Potts, John T; Gardella, Thomas J.

Mol Endocrinol ; 20(4): 931-43, 2006 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-16339275

17.

A doctor's story.

Dean, Thomas.

S D Med ; 65(6): 243, 2012 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-22856015

18.

Chemistry as an expanding resource in protein science: fully synthetic and fully active human parathyroid hormone-related protein (1-141).

Li, Jianfeng; Dong, Suwei; Townsend, Steven D; Dean, Thomas; Gardella, Thomas J; Danishefsky, Samuel J.

Angew Chem Int Ed Engl ; 51(49): 12263-7, 2012 Dec 03.

Artículo en Inglés | MEDLINE | ID: mdl-23124999

19.

Binding Selectivity of Abaloparatide for PTH-Type-1-Receptor Conformations and Effects on Downstream Signaling.

Hattersley, Gary; Dean, Thomas; Corbin, Braden A; Bahar, Hila; Gardella, Thomas J.

Endocrinology ; 157(1): 141-9, 2016 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-26562265

20.

Backbone Modification of a Parathyroid Hormone Receptor-1 Antagonist/Inverse Agonist.

Cheloha, Ross W; Watanabe, Tomoyuki; Dean, Thomas; Gellman, Samuel H; Gardella, Thomas J.

ACS Chem Biol ; 11(10): 2752-2762, 2016 10 21.

Artículo en Inglés | MEDLINE | ID: mdl-27533344

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