RESUMEN
BACKGROUND: This study evaluated the efficacy of an intervention combining the Valencia model of waking hypnosis with cognitive-behavioral therapy (VMWH-CBT) in managing cancer-related pain, fatigue, and sleep problems in individuals with active cancer or who were post-treatment survivors. We hypothesized that four sessions of VMWH-CBT would result in greater improvement in participants' symptoms than four sessions of an education control intervention. Additionally, we examined the effects on several secondary outcome domains that are associated with increases in these symptoms (depression, pain interference, pain catastrophizing, and cancer treatment distress). METHODS: The study design was a randomized controlled crossover clinical trial comparing the VMWH-CBT intervention with education control. Participants (N = 44) received four sessions of both treatments, in a counterbalanced order (n = 22 per order condition). RESULTS: Participants were 89% female (N = 39) with mean age of 61 years (SD = 12.2). They reported significantly greater improvement after receiving the active treatment relative to the control condition in all the outcome measures. Treatment gains were maintained at 3-month follow-up. CONCLUSIONS: This study supports the beneficial effects of the VMWH-CBT intervention relative to a control condition and that treatment gains remain stable. VMWH-CBT-trained clinicians should be accessible for managing symptoms both during and after cancer treatment, though the findings need to be replicated in larger samples of cancer survivors.
Asunto(s)
Terapia Cognitivo-Conductual , Fatiga/terapia , Hipnosis/métodos , Neoplasias/complicaciones , Neoplasias/psicología , Manejo del Dolor/métodos , Trastornos del Inicio y del Mantenimiento del Sueño/etiología , Trastornos del Inicio y del Mantenimiento del Sueño/terapia , Adulto , Anciano , Anciano de 80 o más Años , Supervivientes de Cáncer , Depresión , Fatiga/etiología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Dolor/complicaciones , Trastornos del Inicio y del Mantenimiento del Sueño/psicología , Resultado del TratamientoRESUMEN
OBJECTIVE: Evaluate sleep quality, its correlates, and the effect of telephone-based problem-solving treatment (PST) in active duty postdeployment service members with mild traumatic brain injury (mTBI) SETTING:: Randomized clinical trial. PARTICIPANTS: Active duty service members with combat-related mTBI. STUDY DESIGN: Education-only (EO) and PST groups (N = 178 each) received printed study materials and 12 educational brochures. The PST group additionally received up to 12 PST telephone calls addressing participant-selected issues. Outcomes were evaluated postintervention (6 months) and at 12 months. MAIN MEASURE: Pittsburgh Sleep Quality Index. RESULTS: Sleep quality was manifestly poor in both groups at baseline (Pittsburgh Sleep Quality Index = 12.5 ± 4). Overall sleep quality was significantly different between the PST and EO groups at 6 months (P = .003) but not at 12 months. Longitudinally, PST significantly improved sleep quality at 6 months (P = .001) but not over the follow-up. Low sleep quality was associated with concussion symptoms, pain, depression, and posttraumatic stress disorder at all time points (P < .0001). CONCLUSIONS: Sleep disorders, common in postdeployment service members with mTBI, are strongly associated with the presence of pain, posttraumatic stress disorder, and depression. Telephone-based PST may be an effective therapeutic approach for reducing sleep disorders in this population. Research should focus on maintenance of treatment gains.
Asunto(s)
Conmoción Encefálica/psicología , Conmoción Encefálica/rehabilitación , Personal Militar , Solución de Problemas , Trastornos del Sueño-Vigilia/terapia , Telemedicina , Adulto , Conmoción Encefálica/complicaciones , Femenino , Humanos , Masculino , Persona de Mediana Edad , Trastornos del Sueño-Vigilia/etiología , Trastornos por Estrés Postraumático/etiología , Trastornos por Estrés Postraumático/terapia , Teléfono , Adulto JovenRESUMEN
STUDY DESIGN: Cross-sectional. OBJECTIVE: To preliminarily evaluate the validity of an interview-based spinal cord injury (SCI) neuropathic pain screening instrument. SETTING: Six university-based SCI centers in the United States. METHODS: Clinician diagnoses of neuropathic pain (NP) and non-neuropathic pain subtypes were collected independently of descriptions of the pain characteristics provided by the persons with SCI by using the Spinal Cord Injury Pain Instrument (SCIPI); SCIPI information and physician diagnoses for 82 pain sites of which they were most confident were subsequently compared. RESULTS: Four of the SCIPI items correlated significantly with the NP subtype as determined by the clinician. The best cutoff score for identifying NP was an endorsement of two or more of these four items. Using this cutoff, sensitivity of the SCIPI was 78%, specificity was 73% and overall diagnostic accuracy was 76%. CONCLUSION: In this preliminary study, the SCIPI, which can be administered by a nonclinician, appears to have good sensitivity, specificity and diagnostic accuracy in a SCI population; it may have a role as a screening tool for NP after SCI. Further study is needed.
Asunto(s)
Neuralgia/diagnóstico , Neuralgia/etiología , Dimensión del Dolor/métodos , Traumatismos de la Médula Espinal/complicaciones , Adolescente , Adulto , Anciano , Antidepresivos/uso terapéutico , Estudios Transversales , Ciclohexanoles/uso terapéutico , Depresión/tratamiento farmacológico , Depresión/etiología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Análisis de Componente Principal , Psicometría , Curva ROC , Reproducibilidad de los Resultados , Autoinforme , Traumatismos de la Médula Espinal/psicología , Encuestas y Cuestionarios , Estados Unidos , Clorhidrato de Venlafaxina , Adulto JovenRESUMEN
Longitudinal studies are a powerful tool for characterizing the course of chronic disease. These studies are usually carried out with subjects observed at periodic visits giving rise to panel data. Under this observation scheme the exact times of disease state transitions and sequence of disease states visited are unknown and Markov process models are often used to describe disease progression. Most applications of Markov process models rely on the assumption of time homogeneity, that is, that the transition rates are constant over time. This assumption is not satisfied when transition rates depend on time from the process origin. However, limited statistical tools are available for dealing with nonhomogeneity. We propose models in which the time scale of a nonhomogeneous Markov process is transformed to an operational time scale on which the process is homogeneous. We develop a method for jointly estimating the time transformation and the transition intensity matrix for the time transformed homogeneous process. We assess maximum likelihood estimation using the Fisher scoring algorithm via simulation studies and compare performance of our method to homogeneous and piecewise homogeneous models. We apply our methodology to a study of delirium progression in a cohort of stem cell transplantation recipients and show that our method identifies temporal trends in delirium incidence and recovery.
Asunto(s)
Cadenas de Markov , Modelos Estadísticos , Algoritmos , Biometría/métodos , Delirio/etiología , Trasplante de Células Madre Hematopoyéticas/efectos adversos , Humanos , Funciones de Verosimilitud , Estudios Longitudinales , Neoplasias/complicaciones , Neoplasias/terapia , Factores de TiempoRESUMEN
Human herpesvirus 6B (HHV-6B) frequently reactivates after cord blood transplantation (CBT). We previously reported an association between HHV-6B reactivation and delirium after hematopoietic cell transplantation. In this prospective study, 35 CBT recipients underwent twice-weekly plasma PCR testing for HHV-6 and thrice-weekly delirium assessment until day 84. There was a quantitative association between HHV-6B reactivation and delirium in univariable (odds ratio, 2.88; 95% confidence interval (CI), 0.97-8.59) and bivariable models. In addition, intensified prophylaxis with high-dose valacyclovir mitigated HHV-6B reactivation (adjusted hazard ratio, 0.39; 95% CI, 0.14-1.08). Larger trials are needed to explore the utility of HHV-6B prophylaxis after CBT.
Asunto(s)
Trasplante de Células Madre de Sangre del Cordón Umbilical/efectos adversos , Delirio/etiología , Herpesvirus Humano 6/efectos de los fármacos , Adolescente , Adulto , Niño , Estudios de Cohortes , Trasplante de Células Madre de Sangre del Cordón Umbilical/métodos , Humanos , Persona de Mediana Edad , Adulto JovenRESUMEN
OBJECTIVE: This study examined psychiatric sequelae of traumatic brain injuries in outpatients and their relation to functional disability. METHOD: Fifty consecutive outpatients with traumatic brain injuries who came to a brain injury rehabilitation clinic for initial evaluation were examined for DSM-III-R diagnoses with the use of the National Institute of Mental Health Diagnostic Interview Schedule. The patients completed the Medical Outcomes Study Health Survey to assess functional disability and a questionnaire to assess postconcussion symptoms and self-perceptions of the severity of their brain injuries and cognitive functioning. RESULTS: Thirteen (26%) of the patients had current major depression, and an additional 14 (28%) reported a first-onset major depressive episode after the injury that had resolved. Twelve (24%) had current generalized anxiety disorder, and four (8%) reported current substance abuse. The group with depression and/or anxiety was significantly more impaired than the nondepressed/nonanxious patients according to the Medical Outcomes Study Health Survey measures of emotional role functioning, mental health, and general health perceptions. The depressed/anxious group also rated their injuries as significantly more severe and their cognitive functioning as significantly worse, despite the lack of significant differences in objective measures of severity of injury and Mini-Mental State examination scores. The depressed patients reported significantly more postconcussion symptoms that were increasing in severity over time. CONCLUSIONS: Depression and anxiety are common in outpatients with traumatic brain injuries. Patients with depression or anxiety are more functionally disabled and perceive their injury and cognitive impairment as more severe. Depressed patients report more increasingly severe postconcussion symptoms.
Asunto(s)
Atención Ambulatoria , Lesiones Encefálicas/rehabilitación , Trastornos Mentales/diagnóstico , Adulto , Trastornos de Ansiedad/diagnóstico , Trastornos de Ansiedad/epidemiología , Trastornos de Ansiedad/etiología , Conmoción Encefálica/complicaciones , Conmoción Encefálica/diagnóstico , Lesiones Encefálicas/complicaciones , Comorbilidad , Trastorno Depresivo/diagnóstico , Trastorno Depresivo/epidemiología , Trastorno Depresivo/etiología , Evaluación de la Discapacidad , Femenino , Humanos , Masculino , Trastornos Mentales/epidemiología , Trastornos Mentales/etiología , Prevalencia , Escalas de Valoración Psiquiátrica , Índice de Severidad de la EnfermedadRESUMEN
BACKGROUND: Depression is an important predictor of post therapy quality of life (QOL) in head and neck (H&N) cancer patients. In addition, depression rates may vary among cultures. OBJECTIVE: As part of a larger cross cultural study on post therapy QOL differences in H&N cancer patients, the goal of this project was to translate a well-validated English language depression scale into Swahili, and then validate this scale in Kenyan H&N cancer patients. METHODS, SETTINGS AND SUBJECTS: In Part 1 of the study, we translated the Patient Health Questionnaire-9 (PHQ-9) into Swahili, adhering to established International Quality of Life Association (IQOLA) guidelines. In Part 2, we psychometrically validated the newly translated scale using a prospective study of 48 patients at the Kenyatta National Hospital ENT clinic in Nairobi, Kenya. RESULTS: The Swahili PHQ-9 had good test retest reliability (Intraclass correlation coefficient, 0.71) and internal consistency (Cronbach's alpha = 0.80). It also had good construct validity, as scores correlated strongly with TNM stage (Chi square = 123, p < 0.05), and with the compositeand global scores of an H&N cancer specific QOL scale (UW-QOL, r = -0.87, p < 0.05). CONCLUSION: The Swahili version of the PHQ-9 is a reliable scale in Kenyan H&N cancer patients, and is a valuable tool in screening for and monitoring of depression as a function of QOL in this population.
Asunto(s)
Trastorno Depresivo/diagnóstico , Neoplasias de Cabeza y Cuello/diagnóstico , Psicometría/métodos , Calidad de Vida , Encuestas y Cuestionarios , Adulto , Anciano , Comparación Transcultural , Demografía , Trastorno Depresivo/epidemiología , Femenino , Neoplasias de Cabeza y Cuello/epidemiología , Neoplasias de Cabeza y Cuello/patología , Humanos , Kenia/epidemiología , Masculino , Persona de Mediana Edad , Reproducibilidad de los Resultados , TraduccionesRESUMEN
Information about the epidemiology of delirium has grown tremendously over the past 2 decades. However, methodological challenges have made this area of research difficult to study. Most studies have focused on the prevalence, risk factors, and course of delirium in elderly populations and acute medical and surgical settings. Growing evidence is showing that delirium is a neuropsychiatric syndrome that deserves more research and clinical attention. This article summarizes the current literature on the epidemiology of delirium and discusses some of the important methodological issues in conducting and interpreting research in this area.
Asunto(s)
Delirio/epidemiología , Estudios Transversales , Delirio/diagnóstico , Delirio/etiología , Humanos , Incidencia , Escalas de Valoración PsiquiátricaRESUMEN
The authors examined the effect of antidepressant treatment on cognitive performances in people with mild traumatic brain injury. An 8-week nonrandomized, single-blind, placebo run-in trial of sertraline was completed and neuropsychological testing measures were compared before and after the treatment trial. Results showed improvements in psychomotor speed, recent verbal memory, recent visual memory, and general cognitive efficiency. Improvements were also seen in self-perception of cognitive symptomatology. It appears that successful depression treatment resulted in significant alleviation of cognitive impairments, which may not have been accounted for by natural recovery alone.
Asunto(s)
Antidepresivos/uso terapéutico , Lesiones Encefálicas/complicaciones , Cognición/efectos de los fármacos , Depresión/tratamiento farmacológico , Sertralina/uso terapéutico , Adulto , Depresión/etiología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Pruebas Neuropsicológicas , Resultado del TratamientoRESUMEN
An 8-week, nonrandomized, single-blind, placebo run-in trial of sertraline was conducted on 15 patients diagnosed with major depression between 3 and 24 months after a mild traumatic brain injury. On the Hamilton Rating Scale for Depression, 13 (87%) had a decrease in score of > or = 50% ("response"), and 10 (67%) achieved a score of < or = 7 ("remission") by week 8 of sertraline. There was statistically significant improvement in psychological distress, anger and aggression, functioning, and postconcussive symptoms with treatment.
Asunto(s)
Antidepresivos de Segunda Generación/uso terapéutico , Conmoción Encefálica/complicaciones , Trastorno Depresivo/tratamiento farmacológico , Trastorno Depresivo/etiología , Inhibidores Selectivos de la Recaptación de Serotonina/uso terapéutico , Sertralina/uso terapéutico , Adulto , Conmoción Encefálica/psicología , Trastorno Depresivo/psicología , Femenino , Indicadores de Salud , Humanos , Masculino , Persona de Mediana Edad , Proyectos Piloto , Escalas de Valoración Psiquiátrica , Perfil de Impacto de EnfermedadRESUMEN
Closed head injuries are common, affecting approximately 2 million people annually in the United States. The majority of these are "mild" in the sense of not being associated with prolonged unconsciousness, intracranial bleeding, skull fracture, or protracted periods of confusion. Yet a proportion of such "mild" injuries are accompanied by persisting cognitive, vegetative, and affective-behavioral sequelae, some of which affect day-to-day life. We argue that there is sufficient research to indicate that postconcussional symptoms occur and that they tend to have a predictable configuration. It is necessary to recognize the existence of "Postconcussional Disorder" in our nosology in order to provide more prompt diagnosis and management and to facilitate scholarly communication and research regarding this important neurobehavioral disorder.
Asunto(s)
Traumatismos Cerrados de la Cabeza/complicaciones , Trastornos del Conocimiento/etiología , Traumatismos Cerrados de la Cabeza/diagnóstico , Humanos , Imagen por Resonancia Magnética , Trastornos de la Personalidad/etiología , Escalas de Valoración Psiquiátrica , Trastornos Psicofisiológicos/diagnóstico , Trastornos Psicofisiológicos/etiologíaRESUMEN
OBJECTIVE: To evaluate physical activity as a risk factor for subarachnoid haemorrhage. METHODS: A population based case-control study in King County, Washington. A standardised, personal interview was used to determine physical activity during the past year and at the onset of the bleed for case patients and a similar reference time for control subjects. Conditional logistic regression and a case cross over analysis were performed in which each case patient served as his or her own control. Subjects were 149 men and women with incident, spontaneous subarachnoid haemorrhage and two control subjects per case patient. Control subjects were identified through random digit dialing and matched on age, sex, and respondent type. RESULTS: Four of the 149 (2.7%) case patients were engaged in vigorous physical activity at the time of their subarachnoid haemorrhage. With those who were engaged in non-vigorous or no physical activity serving as the reference group, the relative risk of sustaining a subarachnoid haemorrhage for those engaged in vigorous physical activity was 11.6 (95% confidence interval (95% CI) 1.2-113.2). In the case cross over analysis, the relative risk was 15.0 (95% CI 4.3-52.2). Higher levels of long term regular physical activity over the past year were associated with a lower, but not statistically significant, risk of subarachnoid haemorrhage (test for trend, p=0.3). CONCLUSION: The risk of subarachnoid haemorrhage is increased during vigorous physical activity, although only a few result from this mechanism.
Asunto(s)
Ejercicio Físico/fisiología , Actividad Motora/fisiología , Hemorragia Subaracnoidea/fisiopatología , Adulto , Anciano , Estudios de Casos y Controles , Femenino , Humanos , Masculino , Persona de Mediana Edad , RiesgoRESUMEN
OBJECTIVE: To determine whether psychiatric illness is a risk factor for subsequent traumatic brain injury (TBI). METHODS: Case control study in a large staff model health maintenance organisation in western Washington State. Patients with TBI, determined by International classification of diseases, 9th revision, clinical modification (ICD-9-CM) diagnoses, were 1440 health plan members who had TBI diagnosed in 1993 and who had been enrolled in the previous year, during which no TBI was ascertained. Three health plan members were randomly selected as control subjects, matched by age, sex, and reference date. Psychiatric illness in the year before the TBI reference date was determined by using computerised records of ICD-9-CM diagnoses, psychiatric medication prescriptions, and utilisation of a psychiatric service. RESULTS: For those with a psychiatric diagnosis in the year before the reference date, the adjusted relative risk for TBI was 1.7 (95% confidence interval (CI) 1.4 to 2.0) compared with those without a psychiatric diagnosis. Patients who had filled a psychiatric medication prescription had an adjusted relative risk for TBI of 1.6 (95% CI 1.2 to 2.1) compared with those who had not filled a psychiatric medication prescription. Patients who had utilised psychiatric services had an adjusted relative risk for TBI of 1.3 (95% CI 1.0 to 1.6) compared with those who had not utilised psychiatric services. The adjusted relative risk for TBI for patients with psychiatric illness determined by any of the three psychiatric indicators was 1.6 (95% CI 1.4 to 1.9) compared with those without any psychiatric indicator. CONCLUSION: Psychiatric illness appears to be associated with an increased risk for TBI.